Journals / Veteriner Hekimler Derneği Dergisi / 2026 / Cilt: 97 Sayı: 1

Reactive seizures caused by primary hypoparathyroidism in a dog: case report

Bir köpekte primer hipoparatiroidizm kaynaklı reaktif nöbetler: olgu sunumu

Şamil Buğra Köse(ONDOKUZ MAYIS ÜNİVERSİTESİ)0009-0005-9723-5192
Zülal Feyza Eker(ONDOKUZ MAYIS ÜNİVERSİTESİ)0009-0000-4801-8240
Zeynep Nurselin Kot(ONDOKUZ MAYIS ÜNİVERSİTESİ)0000-0002-0631-5471
Ümit Özcan(ONDOKUZ MAYIS ÜNİVERSİTESİ)0000-0002-0868-6399
Pages
59–65
Publication Date
2026-01-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This case represents the first case presentation in Turkiye to include detailed clinical, laboratory, and treatment process information.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Hypoparathyroidism is a rare endocrine disorder in dogs and is characterized by neurological symptoms associated with hypocalcemia.
📊
Key Findings & Data:This case report provides information on the clinical and laboratory findings, electrocardiogram, and treatment process of a dog with generalized tonic-clonic reactive seizures caused by primary hypoparathyroidism.
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Conclusion & Impact:This case represents the first case presentation in Turkiye to include detailed clinical, laboratory, and treatment process information.
🔬Design:Olgu Sunumu
📍Scope:Comprehensive Sample
⚙️Variables:köpek · hipokalsemi · hipoparatiroidizm

Abstract

Hypoparathyroidism is a rare endocrine disorder in dogs and is characterized by neurological symptoms associated with hypocalcemia. This case report provides information on the clinical and laboratory findings, electrocardiogram, and treatment process of a dog with generalized tonic-clonic reactive seizures caused by primary hypoparathyroidism. In addition to physical and neurological examination, the diagnosis was made by evaluating serum parathyroid hormone and ionized calcium levels. Treatment consisted of intravenous calcium gluconate and oral calcium carbonate and vitamin-D supplements, resulting in complete remission. The patient's ionized calcium, serum calcium, magnesium, and phosphorus levels were monitored at regular intervals during the treatment process. This case represents the first case presentation in Turkiye to include detailed clinical, laboratory, and treatment process information.

Özet

Hipoparatiroidizm, köpeklerde nadir görülen bir endokrin bozukluktur ve hipokalsemiye bağlı nörolojik semptomlarla karakterizedir. Bu olgu sunumu, primer hipoparatiroidizme bağlı gelişen jeneralize tonik-klonik reaktif nöbetler gösteren bir köpekteki klinik ve laboratuvar bulgular, elektrokardiyogram ve tedavi süreci hakkında bilgi vermektedir. Fiziksel ve nörolojik muayeneye ek olarak tanı, serum paratiroid hormon ve iyonize kalsiyum düzeylerinin değerlendirilmesiyle konulmuştur. Tedavi intravenöz kalsiyum glukonat ve oral kalsiyum karbonat takviyelerinden oluşmuş, bunun sonucunda tam iyileşme sağlanmıştır. Tedavi süreci boyunca hastanın iyonize kalsiyum, serum kalsiyum, magnezyum ve fosfor düzeyleri düzenli aralıklarla izlenmiştir. Bu olgu, Türkiye’de klinik, laboratuvar ve tedavi süreci açısından ayrıntılı bilgi içeren ilk olgu sunumunu temsil etmektedir.

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Cite This Article

Köse, Ş. B., Eker, Z. F., Kot, Z. N., Özcan, Ü. (2026). Reactive seizures caused by primary hypoparathyroidism in a dog: case report. Veteriner Hekimler Derneği Dergisi, Cilt: 97 Sayı: 1, 59–65. https://doi.org/10.33188/vetheder.1823156

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References (25)

  1. Henderson AK, Mahony O. Hypoparathyroidism: pathophysiology and diagnosis. Compendium. 2005;27(4):270-276.
  2. Brauer C, Jambroszyk M, Tipold A. Metabolic and toxic causes of canine seizure disorders: a retrospective study of 96 cases. Vet J. 2011;187(2):272-275.
  3. Durão FSAP, Carvalho VdAN, França TN, da Silva JL, dos Santos Filho M, de Farias Brito M. Primary hypoparathyroidism in a dog: a case report. Acta Vet Bras. 2024;18(1).
  4. Erickson AK, Regier PJ, Watt MM, Ham KM, Marvel SJ, Wallace ML, et al. Incidence, survival time, and surgical treatment of parathyroid carcinomas in dogs: 100 cases (2010–2019). J Am Vet Med Assoc. 2021;259(11):1309-1317.
  5. Bush WW, Kimmel SE, Wosar MA, Jackson MW. Secondary hypoparathyroidism attributed to hypomagnesemia in a dog with protein-losing enteropathy. J Am Vet Med Assoc. 2001;219(12):1732-1734.
  6. Diquélou A, Chaput C, Priymenko N, Benoit E. Hypocalcaemia due to nutritional calcium deficiency and hypoparathyroidism in an adult dog. Vet Rec. 2005;156(2):45-48.
  7. Warland J, Skelly B, Knudsen C, Herrtage M. Apparent resolution of canine primary hypoparathyroidism with immunosuppressive treatment. J Vet Intern Med. 2015;29(1):400.
  8. Bruyette DS, Feldman EC. Primary hypoparathyroidism in the dog: report of 15 cases and review of 13 previously reported cases. J Vet Intern Med. 1988;2(1):7-14.
  9. Russell N, Bond K, Robertson I, Parry B, Irwin P. Primary hypoparathyroidism in dogs: a retrospective study of 17 cases. Aust Vet J. 2006;84(8):285-290.
  10. Nelson RW, Couto CG. Small animal internal medicine. 5th ed. St. Louis: Elsevier Health Sciences; 2019.
  11. Berendt M, Farquhar RG, Mandigers PJ, Pakozdy A, Bhatti SF, De Risio L, et al. International veterinary epilepsy task force consensus report on epilepsy definition, classification and terminology in companion animals. BMC Vet Res. 2015;11(1):182.
  12. Schenck PA, Chew DJ. Prediction of serum ionized calcium concentration by use of serum total calcium concentration in dogs. Am J Vet Res. 2005;66(8):1330-1336.
  13. De Risio L, Bhatti S, Muñana K, Penderis J, Stein V, Tipold A, et al. International veterinary epilepsy task force consensus proposal: diagnostic approach to epilepsy in dogs. BMC Vet Res. 2015;11(1):148.
  14. Mooney CT, Shiel RE, Fawcett K, Matthews E, Gunn E. A comparison of canine whole and intact parathyroid hormone concentrations as measured by different assays. J Small Anim Pract. 2019;60(8):507-513.
  15. Murray ME, Boiron L, Buriko Y, Drobatz K, Waddell LS. Total serum and ionized magnesium concentrations in healthy and hospitalized dogs. J Vet Emerg Crit Care. 2023;33(4):427-434.
  16. Jones C, Jablonski SA, Petroff BK, Langlois DK. Relationship between serum magnesium, calcium, and parathyroid concentrations in dogs with abnormally low serum 25-hydroxyvitamin D concentration and chronic or protein-losing enteropathy. J Vet Intern Med. 2023;37(1):101-109.
  17. Lippi I, Guidi G, Marchetti V, Tognetti R, Meucci V. Prognostic role of the product of serum calcium and phosphorus concentrations in dogs with chronic kidney disease: 31 cases (2008–2010). J Am Vet Med Assoc. 2014;245(10):1135-1140.
  18. Tilley LP, Smith FW, Sleeper MM, Kraus M. Manual of canine and feline cardiology. 6th ed. St. Louis: Elsevier Health Sciences; 2024.
  19. Feldman EC, Nelson RW. Hypothyroidism. In: Feldman EC, Nelson RW, editors. Canine and feline endocrinology and reproduction. Philadelphia: WB Saunders; 1996.
  20. Taylor SM, Nelson RW, Couto CG. Small animal internal medicine. 4th ed. St. Louis: Mosby Elsevier; 2009.
  21. Secrest S, Grimes J. Ultrasonographic size of the canine parathyroid gland may not correlate with histopathology. Vet Radiol Ultrasound. 2019;60(6):729-733.
  22. Liles SR, Linder KE, Cain B, Pease AP. Ultrasonography of histologically normal parathyroid glands and thyroid lobules in normocalcemic dogs. Vet Radiol Ultrasound. 2010;51(4):447-452.
  23. Weiss-Guillet EM, Takala J, Jakob SM. Diagnosis and management of electrolyte emergencies. Best Pract Res Clin Endocrinol Metab. 2003;17(4):623-651.
  24. Cardoso M, Melussi M, Costa F, Fagnani R, Holsback L, Zacarias Júnior A, et al. Canine hypoparathyroidism: case report. Arq Bras Med Vet Zootec. 2015;67:353-357.
  25. Lehmann G, Deisenhofer I, Ndrepepa G, Schmitt C. ECG changes in a patient with hypocalcemia due to hypoparathyroidism: hypocalcemia mimicking acute myocardial infarction. Chest. 2000;118(1):260-262.