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Journals / Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi / 2021 / Cilt: 25 Sayı: 3

Investigation of Electrohemical Behaviors of Some Tetracyclines Using Modified Graphite Electrodes

Modifiye Grafit Elektrotlar Kullanılarak Bazı Tetrasiklinlerin Elektrokimyasal Davranışlarının İncelenmesi

Berrin Gürler Akyüz(ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, TEMEL ECZACILIK BİLİMLERİ BÖLÜMÜ)0000-0002-8711-2384
Sabriye Perçin Özkorucuklu(İSTANBUL ÜNİVERSİTESİ, FEN FAKÜLTESİ, MOLEKÜLER BİYOLOJİ VE GENETİK BÖLÜMÜ)0000-0001-9778-2034
Esengül Kır(SÜLEYMAN DEMİREL ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ, KİMYA BÖLÜMÜ)0000-0002-6641-3444
Pages
513–518
Publication Date
2021-12-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The highest anodic signals of TC, CTC and OTC with modified graphite electrode were obtained in BR buffer solution were prepared in 20% asetonitrile-water at pH 2.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, electrochemical behavior of tetracycline (TC), chlortetracycline (CTC) and oxytetracycline (OTC) were investigated in 20; 30 and 40% acetonitrile-water mixture at the pH of 1.5; 2; 2.5; 3; 4 prepared Britton-Robinson (BR) buffers, by the differential pulse voltammetric method.
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Key Findings & Data:The effect of the asetonitrile–water ratio and pH, on the performance of the modified graphite electrode (MIP) was investigated and optimized.
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Conclusion & Impact:The highest anodic signals of TC, CTC and OTC with modified graphite electrode were obtained in BR buffer solution were prepared in 20% asetonitrile-water at pH 2.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Polipirol · Tetrasiklin · Klortetrasiklin

Abstract

In this study, electrochemical behavior of tetracycline (TC), chlortetracycline (CTC) and oxytetracycline (OTC) were investigated in 20; 30 and 40% acetonitrile-water mixture at the pH of 1.5; 2; 2.5; 3; 4 prepared Britton-Robinson (BR) buffers, by the differential pulse voltammetric method. Voltammetric determinations of TC, CTC and OTC were carried out using molecularly imprinted (MIP) and non-imprinted polypyrrole (NIP) modified graphite electrodes. Both types of electrode were prepared by the cyclic voltammetric method. The effect of the asetonitrile–water ratio and pH, on the performance of the modified graphite electrode (MIP) was investigated and optimized. The highest anodic signals of TC, CTC and OTC with modified graphite electrode were obtained in BR buffer solution were prepared in 20% asetonitrile-water at pH 2.

Özet

Bu çalışmada, Tetrasiklin (TC), Klortetrasiklin (CTC) ve Oksitetrasiklin’in (OTC) elektrokimyasal davranışları % 20; 30 ve 40 asetonitril-su karışımlarında hazırlanan Britton-Robinson (BR) tamponlarında pH 1,5; 2; 2,5; 3 ve 4’ te diferansiyel puls voltametri yöntemiyle incelenmiştir. TC, CTC ve OTC’nin voltametrik çalışmaları moleküler baskılı (MIP) ve baskısız (NIP) polimer modifiye grafit elektrotlar kullanılarak gerçekleştirilmiştir. Her iki tür elektrot da dönüşümlü voltametri yöntemiyle hazırlanmıştır. Asetonitril-su oranı ve pH’nın modifiye grafit elektrodun performansı üzerine olan etkisi incelenmiş ve optimize edilmiştir. TC, CTC ve OTC için modifiye grafit elektrot ile en yüksek anodik sinyaller %20 asetonitril-su karışımında hazırlanan BR tamponu ile pH 2’de elde edilmiştir.

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Cite This Article

Akyüz, B. G., Özkorucuklu, S. P., Kır, E. (2021). Investigation of Electrohemical Behaviors of Some Tetracyclines Using Modified Graphite Electrodes. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Cilt: 25 Sayı: 3, 513–518. https://doi.org/10.19113/sdufenbed.852801

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References (21)

  1. Dökmeci, İ. 2007. Sağlık Yüksek Okulları için Farmakoloji. Medikal Yayıncılık, 9573, İstanbul, 301s.
  2. Sapadin, A. N., Fleischmajer, R. 2006. Tetracyclines: Nonantibiotic properties and their clinical implications. Journal of the American Academy of Dermatology, 54(2), 258-265.
  3. Özalp Dural, E. A. 2002. Farmakoloji. Genişletilmiş 3. baskı. Nobel Tıp Kitabevleri. Nobel Matbaacılık, 603, İstanbul, 798s.
  4. Şenyuva, H., Gilbert, J. 2010. Hayvansal gıda maddelerinde veteriner ilaç kalıntılarının taranması. Food Life International Ltd., Edip Sincer, Sincer Dış Ticaret. https://docplayer.biz.tr/3173220-Hayvansal-gida-maddelerinde-veteriner-ilac kalintilarinin-taranmasi.html (Erişim tarihi: 25.12.2020)
  5. Perçin Özkorucuklu, S., Şahin, Y., Alsancak, G. 2008. Voltammetric behavior of sulfamethoxazole on eşectropolymerized-molecularly imprinted overoxidized polypyrrole. Sensors, 8, 8463-8478.
  6. Gürler, B., Perçin Özkorucuklu, S., Kır, E. 2013. Voltammetric behavior and determination of doxycycline in pharmaceuticals at molecularly imprinted and non-imprinted overoxidized polypyrrole electrodes. Journal of Pharmaceutical and Biomedical Analysis, 84, 263-268.
  7. Perçin Özkorucuklu, S., Özcan, L., Şahin, Y., Alsancak, G. 2011. Electroanalytical determination of some sulfonamides on overoxidized polypyrrole electrodes. Australian Journal of Chemistry, 64, 965-972.
  8. Özcan, L., Şahin, Y. 2007. Determination of paracetamol based on electropolymerized-molecularly imprinted polypyrrole modified pencil graphite electrode. Sensors and Actuators B, 127, 362-369.
  9. Özcan, L., Şahin, M., Şahin, Y. 2008. Electrochemical preparation of a molecularly imprinted polypyrrole-modified pencil graphite electrode for determination of askorbic acid. Sensors, 8, 5792-5805.
  10. Gürler, B. 2011. Bazı tetrasiklinlerin elektrokimyasal davranışlarının belirlenmesi ve voltametrik tayinleri için moleküler baskılanmış polimer modifiye elektrotların hazırlanması. Süleyman Demirel Üniversitesi, Fen Bilimleri Enstitüsü, Doktora Tezi, 116s, Isparta.
  11. Cai, W., Gupta, R. B. 2004. Molecularly-imprinted polymers selective for tetracycline binding. Seperation and Purification Technology, 35, 215-221.
  12. Kayaalp, S. O. 2005. Tıbbi Farmakoloji. Hacettepe-Taş Yayını, Feryal Matbaacılık, 27, Ankara, 704s.
  13. Perçin, S. 2008. Bazı sülfonamitlerin elektrokimyasal ve kromatografik davranışlarının incelenmesi. Süleyman Demirel Üniversitesi, Fen Bilimleri Enstitüsü, Doktora Tezi, 170s, Isparta.
  14. Wang, J. 2000. Analytical Electrochemistry. Wiley-VCH, 28272, USA, 209p.
  15. Vega, D., Agüi, L., González-Cortés, A., Yáñéz-Sedeño, P., Pingarrón, J. M. 2007. Volatmmetry and amperometric detection of tetracyclines at multi-wall carbon nanotube modified electrodes. Analytical and Bioanalytical Chemistry, 389, 951-958.
  16. Zhao, F., Zhang, X., Gan, Y. 2004. Determination of tetracyclines in ovine milk by high-performance liquid chromatography with a coulometric electrode array system. Journal of Chromatography A, 1055, 109-114.
  17. Zhou, J., Gerhardt, G.C., Baranski, A., Cassidy, R. 1999. Capillary electrophoresis of some tetracycline antibiotics coupled with reductive fast cyclic voltammetric detection. Journal of Chromatography A, 839, 193-201.
  18. O’Connor, S., Aga, D.S., 2007. Analysis of tetracycline antibiotics in soil: Advances in extraction, clean-up, and quantification. Trends in Analytical Chemistry, 26, No:6.
  19. Pellegrini, G. E., Carpico, G., Coni, E. 2004. Electrochemical sensor for the detection and presumptive identification of quinolone and tetracycline residues in milk. Analytica Chimica Acta, 520, 13-18.
  20. Majidi, M. R., Jouyban, A., Asadpour-Zeynali, K. 2006. Voltammetric behavior and determination of isoniazid in pharmaceuticals by using overoxidized polypyrrole glassy carbon modified electrode. Journal of Electroanalytical Chemistry, 589, 32-37.
  21. Kazemifard A. G., Moore D. E. 1997. Evaluation of amperometric detection for the liquid-chromatografic determination of tetracycline antibiotics and their common contaminants in pharmaceutical formulations. Journal of Pharmaceutical and Biomedical Analysis, 16, 689-696.