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Journals / Selcuk Dental Journal / 2026 / Volume: 12 Issue: 1

Zebrafish, A Model Organism For Research in Dentistry

ZEBRA BALIĞI, DİŞ HEKİMLİĞİ ARAŞTIRMALARINDA MODEL ORGANİZMA

Simge Meşeli(MARMARA ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİ, DİŞ HEKİMLİĞİ PR.)0000-0002-2970-658X
Dilek Tağtekin(MARMARA ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİ, DİŞ HEKİMLİĞİ PR.)0000-0002-2675-1764
Ebru Emekli Alturfan(MARMARA ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİ, DİŞ HEKİMLİĞİ PR.)0000-0003-2419-8587
Pages
—
Publication Date
2025-04-21
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review aims to provide information on the use of zebrafish in many fields of dental research, dental materials and tooth formation.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Zebrafish (Danio rerio) is a tropical freshwater fish, lives in South Asia, India, and Pakistan.
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Key Findings & Data:The use of zebrafish as a model organism in embryology and genetic studies of vertebrates was first mentioned by George Streisinger.
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Conclusion & Impact:This review aims to provide information on the use of zebrafish in many fields of dental research, dental materials and tooth formation.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:zebrafish · model organism · dental research

Abstract

Zebrafish (Danio rerio) is a tropical freshwater fish, lives in South Asia, India, and Pakistan. The use of zebrafish as a model organism in embryology and genetic studies of vertebrates was first mentioned by George Streisinger. Zebrafish has become a popular vertebrate model organism for biomedical research due to its numerous advantages. Zebrafish genome has homologues of 70% human genes, 80% of which are associated with human diseases. Zebrafish embryos are transparent, developes rapidly, and the development stages can be mentored easily by a stereomicroscope. Due to its various advantages, zebrafish has been preferred in neuroscience, cancer, pharmacology and toxicity research for years. Recently, it has begun to be used as a model organism in dental research. This review aims to provide information on the use of zebrafish in many fields of dental research, dental materials and tooth formation.

Özet

Zebra balığı (Danio rerio), Güney Asya, Hindistan ve Pakistan'da yaşayan tropikal bir tatlı su balığıdır. Zebra balığının omurgalıların embriyolojisi ve genetik çalışmalarında model organizma olarak kullanılmasından ilk kez George Streisinger bahsetmiştir. Son yıllarda zebra balığı, sayısız avantajı nedeniyle biyomedikal araştırmalar için popüler bir omurgalı model organizma haline gelmiştir. Zebra balığı genomunun %70'i insan genlerinin homologlarına sahiptir ve bunların %80'i insan hastalıklarıyla ilişkilidir. Zebra balığı embriyoları şeffaftır, hızlı gelişir ve embryoların gelişim aşamaları stereomikroskopla kolaylıkla takip edilebilir. Zebra balığı, çeşitli avantajlarından dolayı nöroloji, kanser, farmakoloji ve toksisite araştırmalarında yıllardır tercih edilmektedir. Son zamanlarda diş hekimliğine ait araştırmalarda model organizma olarak kullanılmaya başlanmıştır. Bu derleme, zebra balığının dental araştırmalar, dental materyaller ve odontogenezis gibi birçok alanda kullanımı hakkında bilgi vermeyi amaçlamaktadır.

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Cite This Article

Meşeli, S., Tağtekin, D., Alturfan, E. E. (2025). Zebrafish, A Model Organism For Research in Dentistry. Selcuk Dental Journal, Volume: 12 Issue: 1. https://doi.org/10.15311/selcukdentj.1446275

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