AI Summary & Key Takeaways
AI InsightOur patients’ risk scores were high and their overall survival was 67 months.
📌 3 Key Takeaways
Özet
Özet: Waldenström Makroglobulinemisi (WM) immunglobulin (Ig)M protein artışı ile karakterize lenfoplazmasitik bir lenfomadır. Anemi, trombositopeni, hepatosplenomegali (HSM), lenfadenopati (LAP) ve nadiren de hipervizkosite hastalığın klinik özelliklerindendir. Yaş, hemoglobin düzeyi, trombosit sayısı, beta-2 mikroglobulin ve monoklonal IgM miktarı prognoz üzerine etkili faktörlerdendir. Hastalarımızın %84’ünde HM, %47’inde SM ve %63’ünde LAP saptandı. En sık başvuru semptomu %47,4 ile halsizlik, yorgunluktu. Hastalarımızın yaklaşık yarısı yüksek risk skoruna sahip olup ortalama yaşam süreleri 67 ay idi. ANAHTAR KELİMELER: Waldenström makroglobulinemisi, prognoz. CLINICAL CHARACTERISTICS AND PROGNOSIS OF PATIENTS WITH WALDENSTRÖM'S MACROGLOBULINEMIA: SINGLE CENTER EXPERIENCE Abstract: Waldenström’s Macroglobulinemia (WM) is a lymphoplasmacytic lymphoma associated with a monoclonal immunoglobulin (Ig)M protein. The clinical manifestations of the disorder are anemia, thrombocytopenia, hepato-splenomegaly (HSM), lymphadenopathy (LAP), and rarely hyperviscosity. Age, hemoglobin level, platelet count, beta-2 microglobulin, and monoclonal IgM concentrations are characteristics required for prognosis. The clinical manifestations in our patients were hepatomegaly 84%, splenomegaly 47%, and lymphadenopathy 63%. The most common presenting symptom was fatigue. Our patients’ risk scores were high and their overall survival was 67 months. KEY WORDS: Waldenström ‘s Macroglobulinemia, prognosis