SavedAdd your journal

Journals / Osmangazi Tıp Dergisi / 2026 / Cilt: 41 Sayı: 2

Evaluation of D Vitamın Levels in Fibromyalgia Syndrome

Fibromiyalji Sendromunda D Vitamin Düzeylerinin Değerlendirilmesi

Merih Özgen(Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Eskişehir Osmangazi University, Eskisehir)0000-0002-8919-968X
Ayşe Merve Aydoğan(FACULTY OF MEDICINE)0000-0002-0223-6354
Ali Uygur(FACULTY OF MEDICINE)0000-0003-0673-5668
Onur Armağan(FACULTY OF MEDICINE)0000-0002-5917-5839
Funda Berkan(FACULTY OF MEDICINE)0000-0001-7531-3704
Fezan Mutlu(ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-9339-4031
Pages
161–165
Publication Date
2019-04-01
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was concluded that the vitamin D levels were low in the majority of patients with fibromyalgia, however the number of tender point detected in patients with fibromyalgia was not related to 25(OH)D values.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The aim of this study was to evaluate 25(OH)D levels in patients with fibromyalgia syndrome and to investigate the relationship between tender point count and 25(OH)D levels.
📊
Key Findings & Data:Sixty one patients with a diagnosis of fibromyalgia were included in this retrospective study between 2016-2017.
💡
Conclusion & Impact:It was concluded that the vitamin D levels were low in the majority of patients with fibromyalgia, however the number of tender point detected in patients with fibromyalgia was not related to 25(OH)D values.
🔬Design:Araştırma Makalesi
📍Scope:2016-2017 Verileri
⚙️Variables:fibromiyalji sendromu · D vitamini · hassas nokta

Abstract

The aim of this study was to evaluate 25(OH)D levels in patients with fibromyalgia syndrome and to investigate the relationship between tender point count and 25(OH)D levels. Sixty one patients with a diagnosis of fibromyalgia were included in this retrospective study between 2016-2017. Demographic data of patients, 25(OH)D levels, number of tender points were evaluated. Patients were classified as vitamin D deficiency (<20 ng/ml), vitamin D insufficient (20-30 ng/ml) and normal vitamin D level (> 30 ng /ml) according to 25(OH)D levels. The mean 25(OH)D levels of 61 patients with firomyalgia was 18.08±11.72. When vitamin D levels were examined, vitamin D deficiency was found in 40 patients with fibromyalgia and vitamin D deficiency in 14 patients with fibromyalgia. Only 7 (11,48%) of the patients with fibromyalgia had normal vitamin D levels. There was no significant correlation between 25(OH)D levels and tender point counts of patients. It was concluded that the vitamin D levels were low in the majority of patients with fibromyalgia, however the number of tender point detected in patients with fibromyalgia was not related to 25(OH)D values.

Özet

Bu çalışmanın amacı, fibromiyalji sendromu olan hastalarda 25(OH)D düzeyini değerlendirmek ve hassas nokta sayısı ile 25(OH)D düzeyi arasındaki ilişkiyi araştırmaktı. Bu retrospektif çalışmaya, 2016-2017 yılları arasında fibromiyalji tanısı almış 61 hasta dahil edildi. Hastaların demografik verileri, 25(OH)D düzeyleri, hassas nokta sayıları değerlendirildi. Hastalar 25(OH)D düzeyleri göre; D vitamini eksikliği (<20 ng/ml), D vitamini yetersizliği (20-30 ng/ml) ve normal D vitamini düzeyi olarak (>30 ng/ml) sınıflandırıldı. Fibromiyalji tanısı olan 61 hastanın 25(OH)D düzeyleri ortalaması 18,08±11,72 idi. D vitamin düzeyleri incelendiğinde, 40 fibromiyalji hastasında D vitamini eksikliği, 14 fibromiyalji hastasında D vitamini yetersizliği olduğu saptandı. Fibromiyalji tanısı olan hastaların sadece 7’sinde (%11,48) D vitamin düzeyleri normal seviyede bulunmuştur. Hastaların 25(OH)D düzeyleri ve hassas nokta sayıları arasında anlamlı bir korelasyon gözlemlenmedi. Fibromiyaljili hastaların büyük çoğunluğunda vitamin D düzeylerinin düşük olduğu, bununla birlikte fibromiyaljili hastalarda saptanan hassas nokta sayısının 25(OH)D değerleriyle ilişkili olmadığı sonucuna varılmıştır.

🔖

Cite This Article

Özgen, M., Aydoğan, A. M., Uygur, A., Armağan, O., Berkan, F., Mutlu, F. (2019). Evaluation of D Vitamın Levels in Fibromyalgia Syndrome. Osmangazi Tıp Dergisi, Cilt: 41 Sayı: 2, 161–165. https://doi.org/10.20515/otd.459018

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (23)

  1. Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014;311(15):1547–1555.
  2. Wolfe F1, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. report of the Multicenter Criteria Committee. Arthritis Rheum. 1990 Feb;33(2):160-72.
  3. Bhatty SA, Shaikh NA, Irfan M, Kashif SM, Vaswani AS, Sumbhai A, et al. Vitamin D deficiency in fibromyalgia. J Pak Med Assoc 2010;60: 949-51.
  4. Altindag O, Ögüt E, Gur A, Gursoy S, Gunay M. Serum vitamin D level and its relation with clinical parameters in fibromyalgia as a neuropathic pain. Orthop Muscular Syst 2014;3: 171.
  5. Okyay R, Koçyigit B, Gürsoy S. Vitamin D levels in women with fibromyalgia and relationship between pain, tender point count and disease activity. Acta Med Mediterr 2016; 32: 243-7.
  6. Makrani AH, Afshari M, Ghajar M, Forooghi Z, Moosazadeh M. Vitamin D and fibromyalgia: a meta-analysis. Korean J Pain. 2017 Oct;30(4):250-257.
  7. Olama SM, Senna MK, Elarman MM, Elhawary G. Serum vitamin D level and bone mineral density in premenopausal Egyptian women with fibromyalgia. Rheumatol Int 2013; 33: 185-92.
  8. Tandeter H, Grynbaum M, Zuili I, Shany S, Shvartzman P. Serum 25-OH vitamin D levels in patients with fibromyalgia. Isr Med Assoc J 2009; 11: 339-42.
  9. Matthana MH. The relation between vitamin d deficiency and fibromyalgia syndrome in women. Saudi Med J. 2011;32:925–9.
  10. Armstrong DJ, Meenagh GK, Bickle I, et al. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol. 2007;26:551–4.
  11. Warner AE, Arnspiger SA. Diffuse musculoskeletal pain is not associated with low vitamin D levels or improved by treatment with vitamin D. J Clin Rheumatol 2008;14(1): 12-16.
  12. Dogru A, Balkarli A, Cobankara V, Tunc SE, Sahin M. Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia Eurasian J Med. 2017;49(2):113-117.
  13. Makrani AH, Afshari M, Ghajar M, Forooghi Z, Moosazadeh M. Vitamin D and fibromyalgia: a meta-analysis. Korean J Pain. 2017;30(4):250-257.
  14. De Rezende Pena C, Grillo LP, Das Chagas Medeiros MM. Evaluation of 25-hydroxivitamin D serum levels in patients with fibromyalgia.J Clin Rheumatol. 2010;16:365–9.
  15. Hauser W, Walitt B, Fitzcharles MA, et al. Review of pharmacological therapies in fibromyalgia syndrome. Arthritis Res Ther 2014;16:201.
  16. Hauser W, Bernardy K, Uc¸eyler N, Sommer C. Treatment of fibromyalgia syndrome with gabapentin and pregabalin–a meta-analysis of randomized controlled trials. Pain 2009;145:69–81.
  17. Sultan A, Gaskell H, Derry S, Moore RA. Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials. BMC Neurol 20081;8:29.
  18. Goldenberg DL, Burckhardt C, Crofford L. Management of fibromyalgia syndrome. JAMA 2004;292:2388–95.
  19. Robinson RL, Kroenke K, Mease P, Williams DA, Chen Y, D’Souza D, Wohlreich M, McCarberg B. Burden of illness and treatment patterns for patients with fibromyalgia. Pain Med 2012;13:1366–76.
  20. Silverman S, Dukes EM, Johnston SS, Brandenburg NA, Sadosky A, Huse DM. The economic burden of fibromyalgia: comparative analysis with rheumatoid arthritis. Curr Med Res Opin 2009;25: 829–40.
  21. Thorpe J, Shum B, Moore RA, Wiffen PJ, Gilron I. Combination pharmacotherapy for the treatment of fibromyalgia in adults. Cochrane Database Syst Rev. 2018 Feb 19;2:CD010585.
  22. Gilron I, Chaparro LE, Tu D, Holden RR, Milev R, Towheed T, DuMerton-Shore D, Walker S. Combination of pregabalin with duloxetine for fibromyalgia: a randomized controlled trial. Pain. 2016 Jul;157(7):1532-40.
  23. Makrani AH, Afshari M, Ghajar M, Forooghi Z, Moosazadeh M. Vitamin D and fibromyalgia: a meta-analysis. Korean J Pain. 2017;30(4):250-257.