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Journals / Osmangazi Tıp Dergisi / 2026 / Cilt: 47 Sayı: 1

Evaluation of Psychological Symptoms and Quality of Life in Patients with Early-Stage Mycosis Fungoides: A Case-Control Study

Erken Evre Mikozis Fungoides Hastalarında Psikolojik Belirtiler ve Yaşam Kalitesinin Değerlendirilmesi: Bir Vaka-Kontrol Çalışması

Esra Ağaoğlu(Eskişehir Osmangazi Üniversitesi Tıp Fakültesi)0000-0001-8985-6224
Hanife Merve Akça(KARAMANOĞLU MEHMETBEY ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-8280-7470
Niyazi Kürşat Çayır(ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0004-0486-3679
Hilal Kaya Erdogan(ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-8172-1920
Ersoy Acer(ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-6041-6636
Pages
95–101
Publication Date
2025-01-17
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, this study demonstrated that quality of life in early-stage MF may be negatively affected in elderly and female patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma.
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Key Findings & Data:Forty patients with early-stage MF and 40 age- and gender-matched healthy controls were included in the study.
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Conclusion & Impact:In conclusion, this study demonstrated that quality of life in early-stage MF may be negatively affected in elderly and female patients.
🔬Design:Klinik Araştırma
📍Scope:Comprehensive Sample
⚙️Variables:Mikozis fungoides · depresyon · anksiyete

Abstract

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma. This study was designed to measure psychological symptoms and health-related quality of life in patients with early-stage MF and compare the results with controls. Forty patients with early-stage MF and 40 age- and gender-matched healthy controls were included in the study. The sociodemographic characteristics of all participants were recorded and Depression, Anxiety and Stress Scale-21 (DASS-21) was administered to measure depression, anxiety and stress levels. Additionally, Skindex-29 was applied to assess the quality of life in MF patients. No significant difference was detected between patient and control groups of MF regarding DASS-21 subscales scores and the total scores. Both symptom and emotion subscale scores of Skindex-29 were found to be statistically higher in female MF patients. Older MF patients had worse symptoms and functional impairment according to Skindex-29. The DASS-21 total scores were positively correlated with all Skindex-29 subscale scores in MF patients. In conclusion, this study demonstrated that quality of life in early-stage MF may be negatively affected in elderly and female patients. Health-related quality of life was more affected in patients with increased levels of depression, anxiety and stress. The quality of life of MF patients can be increased by improving their psychological health.

Özet

Mikozis fungoides (MF) en sık görülen kutanöz T hücreli lenfoma türüdür. Bu çalışma erken evre MF hastalarında psikolojik belirtiler ve sağlıkla ilişkili yaşam kalitesini ölçmek ve sonuçları kontrollerle karşılaştırmak amacıyla tasarlanmıştır. Çalışmaya erken evre MF tanılı 40 hasta ve yaş ve cinsiyete uygun 40 sağlıklı kontrol dahil edildi. Tüm katılımcıların sosyodemografik özellikleri kaydedildi ve depresyon, anksiyete ve stres düzeylerini ölçmek için Depresyon, Anksiyete ve Stres Ölçeği-21 (DASÖ-21) uygulandı. Ayrıca, MF hastalarında yaşam kalitesini değerlendirmek için Skindex-29 uygulandı. MF'li hasta ve kontrol grubu arasında DASS-21 alt ölçek puanları ve toplam puanlar açısından anlamlı bir fark saptanmadı. Skindex-29'un semptom ve duygu alt ölçek puanları kadın MF hastalarında istatistiksel olarak daha yüksek bulundu. Skindex-29'a göre ileri yaş MF hastalarının daha kötü semptomları ve işlevsel bozuklukları bulunmaktaydı. DASS-21 ölçeği toplam puanları MF hastalarında tüm Skindex-29 alt ölçek puanlarıyla pozitif korelasyon gösterdi. Sonuç olarak erken evre MF'te yaşam kalitesi ileri yaş ve kadın hastalarda olumsuz olarak etkilenebilmektedir. Depresyon, anksiyete ve stres düzeyleri yüksek hastalarda sağlıkla ilişkili yaşam kalitesinin daha fazla etkilendiği görüldü. MF hastalarının psikolojik sağlıklarının iyileştirilmesiyle yaşam kaliteleri artırılabilir.

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Cite This Article

Ağaoğlu, E., Akça, H. M., Çayır, N. K., Erdogan, H. K., Acer, E. (2025). Evaluation of Psychological Symptoms and Quality of Life in Patients with Early-Stage Mycosis Fungoides: A Case-Control Study. Osmangazi Tıp Dergisi, Cilt: 47 Sayı: 1, 95–101. https://doi.org/10.20515/otd.1578873

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