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Journals / Osmangazi Tıp Dergisi / 2026 / Cilt: 48 Sayı: 6

Clinical, Biochemical, Lifestyle, and Sleep Characteristics Associated With Chronic Primary Headache in Children and Adolescents: A Cross-Sectional Comparative Study

Çocuk ve Ergenlerde Kronik Primer Baş Ağrısıyla İlişkili Klinik, Biyokimyasal, Yaşam Tarzı ve Uyku Özellikleri: Kesitsel Karşılaştırmalı Çalışma

Müge Baykan(RECEP TAYYİP ERDOĞAN ÜNİVERSİTESİ)0000-0002-8299-6926
Özge Baykan Çopuroğlu(Kayseri University)0000-0003-1014-8845
Yasin Yıldız(RECEP TAYYİP ERDOĞAN ÜNİVERSİTESİ)0000-0002-0602-7795
Pages
1137–1150
Publication Date
2026-09-22
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings support multidimensional assessment of pediatric chronic headache, although causality cannot be inferred from the cross-sectional design.

📌 3 Key Takeaways

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Objective & Hypothesis:Chronic primary headache in childhood causes substantial functional impairment and may involve interacting clinical, familial, biochemical, lifestyle, and sleep-related factors.
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Key Findings & Data:This cross-sectional comparative study evaluated factors independently associated with chronic headache status in 300 participants aged 6–18 years, including 200 with chronic and 100 with episodic primary headache.
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Conclusion & Impact:These findings support multidimensional assessment of pediatric chronic headache, although causality cannot be inferred from the cross-sectional design.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:pediatrik baş ağrısı · uyku · aktigrafi

Abstract

Chronic primary headache in childhood causes substantial functional impairment and may involve interacting clinical, familial, biochemical, lifestyle, and sleep-related factors. This cross-sectional comparative study evaluated factors independently associated with chronic headache status in 300 participants aged 6–18 years, including 200 with chronic and 100 with episodic primary headache. Headache characteristics, family history of migraine, serum 25-hydroxyvitamin D, vitamin B12 and ferritin levels, Pittsburgh Sleep Quality Index scores, and actigraphy-derived sleep and physical activity parameters were assessed. Binary logistic regression was performed, while EEG findings were descriptively evaluated in a clinically selected subgroup. Compared with the episodic group, participants with chronic headache had poorer subjective and objective sleep characteristics, lower vitamin D, vitamin B12 and ferritin levels, and less daily physical activity (all p<0.01). Subjective sleep duration <7 hours/night (adjusted OR [aOR]=3.24), PSQI score >8 (aOR=2.91), vitamin D <20 ng/mL (aOR=2.17), physical activity <30 minutes/day (aOR=1.98), and family history of migraine (aOR=2.83) were independently associated with chronic headache status. In the objective sleep model, sleep efficiency <85% (aOR=3.07), wake after sleep onset >40 minutes/night (aOR=2.48), and total sleep time <7 hours/night (aOR=2.91) remained independently associated with chronic headache, alongside low vitamin D status and physical activity. EEG abnormalities were unrelated to headache intensity (p>0.05). These findings support multidimensional assessment of pediatric chronic headache, although causality cannot be inferred from the cross-sectional design.

Özet

Çocukluk çağındaki kronik primer baş ağrısı, önemli düzeyde işlevsel yetersizliğe yol açmakta ve klinik, ailesel, biyokimyasal, yaşam tarzı ve uyku ile ilişkili faktörlerin etkileşimini içerebilmektedir. Bu kesitsel karşılaştırmalı çalışmada, 6–18 yaş aralığında kronik primer baş ağrısı olan 200 ve epizodik primer baş ağrısı olan 100 olmak üzere toplam 300 katılımcı değerlendirildi. Baş ağrısı özellikleri, ailede migren öyküsü, serum 25-hidroksivitamin D, vitamin B12 ve ferritin düzeyleri, Pittsburgh Uyku Kalitesi İndeksi puanları ile aktigrafiyle ölçülen uyku ve fiziksel aktivite parametreleri incelendi. Kronik baş ağrısı durumuyla bağımsız olarak ilişkili faktörleri belirlemek amacıyla ikili lojistik regresyon analizi uygulandı. EEG bulguları ise klinik olarak seçilmiş bir alt grupta betimsel olarak değerlendirildi. Epizodik gruba kıyasla kronik baş ağrısı olan katılımcılarda öznel ve nesnel uyku özellikleri daha kötü, vitamin D, vitamin B12 ve ferritin düzeyleri daha düşük ve günlük fiziksel aktivite daha azdı (tümü p<0,01). Gecelik öznel uyku süresinin <7 saat olması (düzeltilmiş OR [dOR]=3,24), PSQI puanının >8 olması (dOR=2,91), vitamin D düzeyinin <20 ng/mL olması (dOR=2,17), fiziksel aktivitenin <30 dakika/gün olması (dOR=1,98) ve ailede migren öyküsü (dOR=2,83) kronik baş ağrısı durumuyla bağımsız olarak ilişkiliydi. Nesnel uyku modelinde uyku etkinliğinin <%85, uyku başlangıcı sonrası uyanıklığın >40 dakika/gece ve toplam uyku süresinin <7 saat/gece olması bağımsız ilişkisini korudu. EEG anormallikleri baş ağrısı şiddetiyle ilişkili değildi (p>0,05). Bulgular, pediatrik kronik baş ağrısında çok boyutlu değerlendirmeyi desteklemektedir; ancak kesitsel tasarım nedensellik çıkarımına izin vermemektedir.

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Cite This Article

Baykan, M., Çopuroğlu, Ö. B., Yıldız, Y. (2026). Clinical, Biochemical, Lifestyle, and Sleep Characteristics Associated With Chronic Primary Headache in Children and Adolescents: A Cross-Sectional Comparative Study. Osmangazi Tıp Dergisi, Cilt: 48 Sayı: 6, 1137–1150. https://doi.org/10.20515/otd.1931469

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