Journals / Online Türk Sağlık Bilimleri Dergisi / 2026 / Cilt: 6 Sayı: 3

The Role of Vitamin B12 and Folate in Habitual Abortion

Habitüel Abortusta Vitamin B12 ve Folatın Rolü

Samettin Çelik(Sağlık Bilimleri Üniversitesi Samsun Uygulama ve Araştırma Merkezi)0000-0002-6407-1129
Canan Soyer Çalışkan(Sağlık Bilimleri Üniversitesi Samsun Uygulama ve Araştırma Merkezi)0000-0002-9889-5249
Burak Yaşar(Sağlık Bilimleri Üniversitesi Samsun Uygulama ve Araştırma Merkezi)0000-0003-4070-1867
Bahadır Yazıcıoğlu(Sağlık Bilimleri Üniversitesi Samsun Uygulama ve Araştırma Merkezi)0000-0003-4397-2769
Eda Türe(Sağlık Bilimleri Üniversitesi Samsun Uygulama ve Araştırma Merkezi)0000-0003-0124-8721
Hasan Ulubaşoğlu(Sağlık Bilimleri Üniversitesi Samsun Uygulama ve Araştırma Merkezi)0000-0001-9157-0612
Pages
347–352
Publication Date
2021-09-05
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In our study, we aimed to reveal the relationship between habitual abortion with folate and vitamin B12 levels.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Although several pathophysiological mechanisms are defined in the etiology of habitual abortion, still causes half of the cases haven’t been clarified yet.
📊
Key Findings & Data:It has been reported that folate and vitamin B12 are effective in early pregnancy complications.
💡
Conclusion & Impact:In our study, we aimed to reveal the relationship between habitual abortion with folate and vitamin B12 levels.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Folat · Habitüel abort · Vitamin B12

Abstract

Objective: Although several pathophysiological mechanisms are defined in the etiology of habitual abortion, still causes half of the cases haven’t been clarified yet. It has been reported that folate and vitamin B12 are effective in early pregnancy complications. In our study, we aimed to reveal the relationship between habitual abortion with folate and vitamin B12 levels.

Özet

Amaç: Habitüel abortus etiyolojisinde birçok patofizyolojik mekanizma tanımlanmış olsa da vakaların yarısının nedeni hala aydınlatılamamıştır. Folat ve B12 vitamininin erken gebelik komplikasyonları üzerinde etkili olduğu bildirilmektedir. Biz de çalışmamızda habitüel abortus ile folat ve vitamin B12 düzeyleri arasındaki ilişkiyi ortaya koymayı amaçladık.

🔖

Cite This Article

Yılmaz, Z., Güvey, H., Çelik, S., Çalışkan, C. S., Yaşar, B., Yazıcıoğlu, B., Türe, E., Ulubaşoğlu, H. (2021). The Role of Vitamin B12 and Folate in Habitual Abortion. Online Türk Sağlık Bilimleri Dergisi, Cilt: 6 Sayı: 3, 347–352. https://doi.org/10.26453/otjhs.822978

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (24)

  1. Von Eye Corleta H. It is time to respect the American Society for Reproductive Medicine definition of recurrent pregnancy loss. Fertil Steril. 2010;94(4):e61. doi:10.1016/j.fertnstert. 2010.06.020
  2. Regan L, Backos M, Rai R. Royal College of Obstetricians & Gynaecologists. The investigation and treatment of couples with recurrent first-trimester and second trimester miscarriage. Guideline No. 17, 2011. https://www.rcog.org.uk/globalassets/documents/guidelines/gtg_17.pdf. Accessed November 8, 2020.
  3. Fritz M, Goldberg J, McClure RD et al. The Practice Committee of the American Society for Reproductive Medicine. Evaluation and treatment of recurrent pregnancy loss: a committee opinion. 2012. https://www.fertstert.org/action/showPdf?pii=S0015-0282%2812%2900701-7. Accessed November 8,2020.
  4. Silver RM, Branch DW, Goldenberg R, Iams JD, Klebanoff MA. Nomenclature for pregnancy outcomes Time for a change. American Collage of Obsterics and Gynecology. 2011;118(6):1402-1408. doi:10.1097/AOG.0b013e3182392977
  5. Pei C, Kim YJ, Baek K. Pathogenetic factors involved in recurrent pregnancy loss from multiple aspects. Obstet Gynecol. 2019;62(4):212-223. doi:10.5468/ogs.2019.62.4.212
  6. Solé-Navais P, Cavallé-Busquets P, Fernandez-Ballart JD, Murphy MM. Early pregnancy B vitamin status, one carbon metabolism, pregnancy outcome and child development. Biochimie. 2016;126:91-96. doi:10.1016/j.biochi.2015.12.003
  7. Yang T, Gu Y, Wei X et al. Periconceptional folic acid supplementation and vitamin B 12 status in a cohort of Chinese early pregnancy women with the risk of adverse pregnancy outcomes. J Clin Biochem Nutr. 2017;60(2):136-142. doi:10.3164/jcbn.16-45
  8. Sukumar N, Rafnsson SB, Kandala N, Bhopal R, Yajnik CS, Saravanan P. Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta analysis. Am J Clin Nutr. 2016;103:1232-1251. doi:10.3945/ajcn.115.123083
  9. Dror DK, Allen LH. Interventions with Vitamins B6, B12 and C in pregnancy. Pediatr Perinat Epidemiol. 2012;26(1):55-74. doi:10.1111/j.1365-3016.2012.01277.x
  10. George L, Mills JL, Johansson ALV, et al. Plasma folate levels and risk of spontaneous abortion. J Am Med Assoc. 2002;288(15):1867-1873. doi:10.1001/jama.288.15.1867.
  11. Mujawar SA, Patil VW, Daver RG. Study of serum homocysteine, folic acid and vitamin B12 in patients with preeclampsia. Indian J Clin Biochem. 2011;26(3):257-260. doi:10.1007/s12291-011-0109-3
  12. Puri M, Kaur L, Walia GK, Mukhopadhhyay R, Pal M. MTHFR C677T polymorphism, folate, vitamin B 12 and homocysteine in recurrent pregnancy losses: a case control study among north Indian women. J Perinat Med. 2013;41(5):8-13. doi:10.1515/jpm-2012-0252.
  13. Al-badri HJA, Abdul-hassan M. Serum total homocysteine level in Iraqi woman with unexplained recurrent miscarriage. J Pak Med A. 2019;69(8):29.
  14. Li Y, Gao R, Liu X et al. Folate deficiency could restrain decidual angiogenesis in pregnant mice. Nutrients. 2015;7(8):6425-6445. doi:10.3390/nu7085284
  15. Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999;19:217-246. doi:10.1146/annurev. nutr.19.1.217
  16. Sande H Van, Jacquemyn Y, Karepouan N, Ajaji M. Vitamin B12 in pregnancy: Maternal and fetal/neonatal effects-A review. Open J Obstet Gynecol. 2013;03(07):599-602. doi:10.4236/ojog.2013. 37107
  17. Allen LH, Jones KM. Vitamin B12. In: Coates PM, ed. Encyclopedia of dietary supplements. 2nd ed. Boca Raton: CRC Press; 2015:431-452.
  18. Scholl TO, Johnson WG. Folic acid: influence on the outcome of pregnancy. Am J Clin Nutr. 2000;71:1295-1303. doi:10.1093/ajcn/71.5.1295s
  19. Hübner U, Alwan A, Jouma M, Tabbaa M, Schorr H, Herrmann W. Low serum vitamin B12 is associated with recurrent pregnancy loss in Syrian women. Clin Chem Lab Med. 2008;46(9):12651269. doi:10.1515/CCLM.2008.247
  20. Krishnaveni GV, Hill JC, Veena SR et al. Low plasma vitamin B12 and high folate concentrations in pregnancy are associated with gestational diabesity and incident diabetes. Diabetologia. 2009;52(11):2350-2358. doi:10.1007/s00125-009-1499-0
  21. Su M, Bussen S, Ruppert D, Steck T. Serum levels of folate and cobalamin in women with recurrent spontaneous abortion. Human Reproduction. 1997;12(10):2292-2296. doi:10.1093/humrep/12.10.2292
  22. Ellatef DMA, Beteha GA, Hasan MM, Eid MA. The Relation between serum homocystiene level and recurrent abortion in Egyptian women. The Egyptian Journal of Hospital Medicine. 2018:70(5):731-738. doi:10.12816/0043975
  23. Sukumar N, Rafnsson SB, Kandala N, Bhopal R, Yajnik CS, Saravanan P. Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta analysis. Am J Clin Nutr. 2016;103:1232-1251. doi:10.3945/ajcn.115.123083
  24. Puri M, Kaur L, Walia GK, Mukhopadhhyay R, Pal M. MTHFR C677T polymorphism, folate, vitamin B 12 and homocysteine in recurrent pregnancy losses: a case control study among north Indian women. J Perinat Med. 2013;41(5):8-13. doi:10.1515/jpm-2012-0252.