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Journals / Online Türk Sağlık Bilimleri Dergisi / 2023 / Cilt: 8 Sayı: 4

Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model

Şeyma Nur Başarır Bozkurt(SAKARYA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF MEDICAL PHARMACOLOGY)0000-0002-2986-5089
Oguz Mutlu(Kocaeli University, Faculty of Medicine. Department of Pharmacology)0000-0003-0952-0742
Daniel Bermejo Rodriguez(National Institute of Mental Health)0000-0002-4512-2568
David Kacer(National Institute of Mental Health)0000-0003-1780-5609
Pelin Tanyeri(SAKARYA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF PHARMACOLOGY AND CLINICAL PHARMACOLOGY)0000-0002-2987-5834
Pınar Cobantürk(Kocaeli University, Faculty of Medicine. Department of Pharmacology)0000-0001-5917-8928
Karel Vales(National Institute of Mental Health)0000-0001-7892-4535
Pages
525–532
Publication Date
2023-12-18
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: According to our results, AKH might affect dopaminergic and glutamatergic systems and reverse the effects of MK-801, possibly affecting NMDA receptors.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Adipokinetic hormone (AKH) plays a role in sugar and lipid metabolism in insects.
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Key Findings & Data:Materials and Methods: We administered AKH/RPCH peptides for 4 days sub-chronically, both in naive rats and also in the MK-801-induced schizophrenia rat model.
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Conclusion & Impact:Conclusion: According to our results, AKH might affect dopaminergic and glutamatergic systems and reverse the effects of MK-801, possibly affecting NMDA receptors.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Adipokinetik hormon · nörokimya · nörotransmitter

Abstract

Objective: Adipokinetic hormone (AKH) plays a role in sugar and lipid metabolism in insects. Previous studies of AKH showed memory improvements in a schizophrenia rat model that displayed memory impairment and reduced depression in a rat olfactory bulbectomy model. In this study, we investigated the effects of the adipokinetic hormone/red pigment-concentrating hormone (AKH/RPCH) family of peptides on brain neurotransmitter levels and brain neurochemistry in a schizophrenia rat model. Materials and Methods: We administered AKH/RPCH peptides for 4 days sub-chronically, both in naive rats and also in the MK-801-induced schizophrenia rat model. Liquid chromatography-mass spectrometry apparatus was used for targeted and untargeted analysis of rat neurochemistry. Results: Increased brain glutamate levels characteristic of MK-801 peptide-treated rats were significantly reduced by AKH. Furthermore, AKH also increased brain dopamine levels in both naive and MK-801 rats. Metabolomic studies have shown that AKH affects lipid and glutamate metabolism, while hypertrehalosaemic hormone plays a role in sugar metabolism and inflammation. Conclusion: According to our results, AKH might affect dopaminergic and glutamatergic systems and reverse the effects of MK-801, possibly affecting NMDA receptors.

Özet

Amaç: Adipokinetik hormon (AKH) böceklerde şeker ve lipid metabolizmasında rol oynar. Önceki çalışmalarda AKH sıçan şizofeni modelinde belleği ve sıçan olfaktör bulbektomi modelinde depresyonu düzelttiği gösterilmiştir. Bu çalışmada, adipokinetik hormon/kırmızı pigment konsantre edici hormon (AKH/RPCH) ailesi peptidlerinin sıçan şizofreni modelinde beyin nörotransmitter seviyesi ve beyin nörokimyası üzerine etkisi araştırılmıştır. Materyal ve Metot: Peptidleri hem naif sıçanlarda hem de MK-801 ile indüklenmiş sıçan şizofreni modelinde 4 gün boyunca subkronik olarak uyguladık. Likid kromatografi-kütle spektrometri cihazı nörokimyanın hedeflenmiş ve hedeflenmemiş analizi için kullanıldı. Bulgular: AKH anlamlı olarak MK-801 uygulanmış sıçanlarda artmış beyin glutamat seviyesini düşürmüştür. AKH ayrıca hem naif sıçanlarda hem MK-801 uygulanmış sıçanlarda beyin dopamin seviyesini artırdı. Metabolomik çalışmalar adipokinetik hormonun lipid ve glutamat metabolizmasını etkilediğini, hipertrehalosemik hormonun ise şeker metabolizması ve enflamasyonda rol oynadığını gösterdi. Sonuç: Sonuçlarımıza göre AKH dopaminerjik ve glutamaterjik sistemi etkileyebilir ve MK-801’in etkilerini muhtemelen NMDA reseptörleri üzerinden tersine çeviriyor olabilir.

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Cite This Article

Bozkurt, Ş. N. B., Mutlu, O., Rodriguez, D. B., Kacer, D., Tanyeri, P., Cobantürk, P., Vales, K. (2023). Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model. Online Türk Sağlık Bilimleri Dergisi, Cilt: 8 Sayı: 4, 525–532. https://doi.org/10.26453/otjhs.1374368

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