SavedAdd your journal

Journals / Online Türk Sağlık Bilimleri Dergisi / 2023 / Cilt: 8 Sayı: 4

Comparison of Brain Natriuretic Peptide and Other Laboratory Parameters of Those Who Died From Coronavirus Disease and Those Who Were Discharged

Koronavirüs Hastalığı Nedeniyle Ölenlerle Taburcu Olanların Beyin Natriüretik Peptit ve Diğer Laboratuvar Parametrelerinin Karşılaştırılması

Mehmet Özdin(SAKARYA SAĞLIK BAKANLIĞI SAKARYA ÜNİVERSİTESİ EĞİTİM VE ARAŞTIRMA HASTANESİ)0000-0003-3077-7171
Mehmet Köroğlu(SAKARYA ÜNİVERSİTESİ, TIP FAKÜLTESİ, TIP PR.)0000-0001-8101-1104
Selcuk Yaylacı(SAKARYA ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-6768-7973
Erdem Çokluk(SAKARYA ÜNİVERSİTESİ, TIP FAKÜLTESİ, TIP PR.)0000-0002-6205-5109
İbrahim Kocayiğit(SAKARYA ÜNİVERSİTESİ, TIP FAKÜLTESİ, TIP PR.)0000-0001-8295-9837
Aziz Öğütlü(SAKARYA ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-3840-4038
Pages
441–447
Publication Date
2023-12-18
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

More comprehensive studies are needed on this subject.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectıve: In this study, we aim to compare the brain natriuretic peptide (BNP) of patients who were diagnosed with COVID-19 infection, who were hospitalized and discharged, and those who died.
📊
Key Findings & Data:Materials and Methods: The study was conducted on 474 patients diagnosed with COVID-19 disease.
💡
Conclusion & Impact:More comprehensive studies are needed on this subject.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Beyin natriüretik peptid · C-reactive protein · D-dimer

Abstract

Objectıve: In this study, we aim to compare the brain natriuretic peptide (BNP) of patients who were diagnosed with COVID-19 infection, who were hospitalized and discharged, and those who died. Materials and Methods: The study was conducted on 474 patients diagnosed with COVID-19 disease. Information of 56 patients who died and 418 patients with COVID-19 who were discharged were obtained from the hospital information management system (HIMS) and analyzed retrospectively. The relationship between BNP, white blood cell (WBC), neutrophil (NEU), lymphocyte (LYM), platelet (PLT), Procalcitonin (PCT), High Sensitive Troponin I (hs Tn I), D-dimer and C-Reactive Protein (CRP) levels in deceased patients and discharged patients researched. Results: There was no statistically significant difference in mortality between women and men (p=0.385). There was no statistically significant difference in BNP, WBC, NEU, LYM, platelet, PCT and hs Tn I values between those who died and those who were discharged. D-dimer and CRP values of those who died and discharged were statistically significant (p< 0.031 and 0.020, respectively). Conclusions: Increased levels of CRP and D-dimer were found to be associated with mortality. More comprehensive studies are needed on this subject.

Özet

Amaç: Bu çalışmada amacımız, COVID-19 enfeksiyonu teşhisi alıp hastanede yatıp taburcu olanlar ile ölen hastaların beyin natriüretik peptidini (BNP) karşılaştırmaktır. Materyal ve Metot: Çalışma COVID-19 hastalığı teşhisi konan 474 hasta üzerinde gerçekleştirildi. Ölen 56 hasta ile taburcu olan 418 COVID-19 hastasının bilgileri hastane bilgi yönetim sisteminden (HBYS) alındı ve geriye dönük olarak analiz edildi. Ölen hastalar ile taburcu olan hastalarda BNP, beyaz küre hücresi (WBC) , nötrofil (NEU), lenfosit (LYM), trombosit (PLT), Procalsitonin (PCT), Yüksek Duyarlı Troponin I (hs Tn I), D-dimer ve C-Reaktif Protein (CRP) düzeyleri arasındaki ilişki araştırıldı. Bulgular: Kadınlar ile erkekler arasında mortalite açısından istatistiksel olarak anlamlı bir fark yoktu (p=0,385). Ölenler ile taburcu olanlar arasında BNP, WBC, NEU, LYM, trombosit, PCT ve hs Tn I değerlerinde istatistiksel olarak anlamlı fark yoktu. Ölenler ile taburcu olanların D-dimer (p<0,031) ve CRP (p<0,020) değerleri istatistiksel olarak anlamlı bulundu. Sonuç: Artan CRP ve D-dimer düzeylerinin mortalite ile ilişkili olduğu bulundu. Bu konuda daha kapsamlı çalışmalara ihtiyaç vardır.

🔖

Cite This Article

Özdin, M., Köroğlu, M., Yaylacı, S., Çokluk, E., Kocayiğit, İ., Öğütlü, A. (2023). Comparison of Brain Natriuretic Peptide and Other Laboratory Parameters of Those Who Died From Coronavirus Disease and Those Who Were Discharged. Online Türk Sağlık Bilimleri Dergisi, Cilt: 8 Sayı: 4, 441–447. https://doi.org/10.26453/otjhs.1242798

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (29)

  1. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020;395(10229):1054–1062. doi:10.1016/S0140-6736(20)30566-3
  2. Gandhi RT, Lynch JB, Del Rio C. Mild or moderate Covid-19. N Engl J Med. 2020;383(18):1757-1766. doi:10.1056/NEJMcp2009249
  3. Guo T, Fan Y, Chen M, Wu X, Zhang L, He T. Cardiovascular implications of fatal outcomes of patients with Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. 2020;5(7):811–818. doi:10.1001/jamacardio.2020.1017
  4. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. doi:10.1016/S0140-6736(20)30183-5
  5. Özdin M. Atopik Dermatiti Olan Çocuklarda Hematolojik ve Alerjik Değerler Arasındaki İlişki, Balıkesir Medical Journal. 2020;4(3):1-6. doi:10.33716 bmedj.734178
  6. Yazar H, Kayacan Y, Özdin M. Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19. Bezmialem Science. 2021;9 (Supplement 1):4-8. doi:10.14235/bas.galenos.2020.4884
  7. Halaby R, Popma CJ, Cohen A, et al. D-dimer elevation and adverse outcomes. J Thromb Thrombolysis. 2015;39(1):55-59. doi:10.1007/s11239-014-1101-6
  8. Braithwaite S. Procalcitonin: new insights on regulation and origin. Crit Care Med. 2000;28(2):586–588.
  9. Avcıküçük M, Bakır F, Topçuoğlu C, Güçtekin A. Akut koroner sendromda troponin T ve troponin I. Turk Hij Den Biyol Derg. 2011;68(3):127-134. doi:10.5505/ TurkHijyen.2011.85047
  10. Dede H, Sametoğlu F, İnal BB, Şahin M, Güvenen G. Evaluation of serum pro-BNP and hs-CRP levels with echocardiography Data in Patients with Heart Failure. Istanbul Med J. 2010;11(3):97-103.
  11. Bajwa EK, Januzzi JL, Gong MN, Thompson BT, Christiani DC. Prognostic value of plasma N-terminal probrain natriuretic peptide levels in the acute respiratory distress syndrome. Crit Care Med. 2008;36(8):2322-2327. doi:10.1097/CCM. 0b013e318181040d
  12. Yang J, Yang Y, Liu Q. Study on the levels of main inflammatory factors in septic shock and their clinical significance. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019;31(6):680–683. doi:10.3760/cma.j.issn.2095-4352.2019.06.004
  13. Tao G, Yongzhen F, Ming C, Xiaoyan W, Lin Z, Tao H. Cardiovascular implications of fatal outcomes of patients with Coronavirus Disease 2019. JAMA Cardiol. 2020;5(7):1–8. doi:10.1001/jamacardio. 2020.1017
  14. Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Pathological findings of COVID-19 associated with acute respiratory distress syndrome. The Lancet Respiratory Medicine. 2020;8(4):420-422. doi:10.1016/S2213-2600(20)30076-X
  15. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5
  16. Bonetti G, Manelli F, Patroni A, Bettinardi A, Borrelli G, Fiordalisi G. Laboratory predictors of death from coronavirus disease 2019 (COVID-19) in the area of Valcamonica, Italy. Clin Chem Lab Med. 2020;58(7):1100-1105. doi:10.1515/cclm-2020-0459
  17. Bonetti G, Manelli F, Patroni A, et al. Laboratory predictors of death from coronavirus disease 2019 (COVID-19) in the area of Valcamonica, Italy. Clin Chem Lab Med. 2020;58(7):1100-1105. doi:10.1515/cclm-2020-0459
  18. Tan W, Zhao X, Ma X, et al. A Novel Coronavirus Genome Identified in a Cluster of Pneumonia Cases - Wuhan, China 2019-2020. China CDC Wkly. 2020;2(4):61-62. doi:10.46234/ccdcw2020.017
  19. Guan W. Clinical Characteristics of Coronavirus Disease 2019 in China. NEJM. 2020;382(18):1708-1720. doi:10.1056/NEJMoa2002032
  20. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239–1242. doi:10.1001/jama.2020.2648
  21. Kilbas I, Kahraman Kilbas EP, Ciftci IH. The relationship of procalcitonin level with the severity of COVID-19 infection. Phnx Med J. 2021;3(3):97-100. doi:10.38175/phnx.899465
  22. Komaru Y, Doi K. Does a slight change in serum creatinine matter in coronavirus disease 2019 (COVID-19) patients? Kidney Res Clin Pract. 2021;40(2):177-179.
  23. Terpos E, Stathopoulos IN, Elalamy I, Kastritis E, Sergentanis TN, Politou M. Hematological findings and complications of COVID-19. Am J Hematol. 2020;95(7):834-847.
  24. Pan F, Yang L, Li Y, et al. Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study. Int J Med Sci. 2020;17(9):1281-1292. doi:10.7150/ijms.46614
  25. Liao D, Zhou F, Luo L. Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID-19: a retrospective cohort study. Lancet Haematol. 2020;7(9):671-678. doi:10.1016/S2352-3026(20)30217-9
  26. Ozdin M, Kaya H, Gulacti U, et al. The diagnostic value of neutrophil to lymphocyte ratio in determining the severity of COVID-19. IMC J Med Sci. 2022;16(1):1-7. doi:10.55010/imcjms.16.001
  27. Shi S, Qin M, Shen B, et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol. 2020;5(7):802-810. doi:10.1001/jamacardio.2020.0950
  28. Terpos E, Stathopoulos IN, Elalamy I, Kastritis E, Sergentanis TN, Politou M. Hematological findings and complications of COVID-19. Am J Hematol. 2020;95(7):834-847. doi:10.1002/ajh.25829
  29. Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood. 2020;135(23):2033-2040. doi:10.1182/blood.2020006000