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Journals / Online Türk Sağlık Bilimleri Dergisi / 2026 / Cilt: 9 Sayı: 3

Association of Hemogram Parameters with Body Mass Index in Knee Osteoarthritis

Diz Osteoartritinde Hemogram Parametrelerinin Vücut Kitle İndeksi ile İlişkisi

Koksal Gundogdu(Denizli state hospital)0000-0001-6820-5625
Gülşah Gündoğdu(PAMUKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-9924-5176
Alper Kurtoğlu(SAKARYA ÜNİVERSİTESİ)0000-0001-9890-1330
Pages
202–208
Publication Date
2024-09-16
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: The findings revealed significantly elevated levels of serum Neutrophil-to-Lymphocyte Ratio (NLR) and C-reactive protein (CRP) in severe KOA compared to mild KOA (P 30 in mild KOA groups, while mean blood NLR was notably higher in patients with BMI=30-35 in severe KOA groups.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study aims to investigate the relationship between hemogram parameters, which are low-cost, easy, routinely applied low-grade inflammation indicators, and severity of knee osteoarthritis (KOA) and obesity.
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Key Findings & Data:Materials and Methods: This study involved 140 KOA patients aged 45 to 85 who underwent knee radiographs, weight and height measurements, and routine laboratory tests.
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Conclusion & Impact:Results: The findings revealed significantly elevated levels of serum Neutrophil-to-Lymphocyte Ratio (NLR) and C-reactive protein (CRP) in severe KOA compared to mild KOA (P 30 in mild KOA groups, while mean blood NLR was notably higher in patients with BMI=30-35 in severe KOA groups.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Diz osteoartriti · nötrofil/lenfosit oranı · nötrofil/monosit oranı

Abstract

Objective: This study aims to investigate the relationship between hemogram parameters, which are low-cost, easy, routinely applied low-grade inflammation indicators, and severity of knee osteoarthritis (KOA) and obesity. Materials and Methods: This study involved 140 KOA patients aged 45 to 85 who underwent knee radiographs, weight and height measurements, and routine laboratory tests. Recorded data included demographic information (gender, age), body mass index (BMI), routine hemogram, and laboratory parameters. Patients were categorized into two groups based on their Kellgren-Lawrence (KL) scores (mild: KL 1-3, severe: KL 4) and four groups according to their BMI (BMI 35). Results: The findings revealed significantly elevated levels of serum Neutrophil-to-Lymphocyte Ratio (NLR) and C-reactive protein (CRP) in severe KOA compared to mild KOA (P 30 in mild KOA groups, while mean blood NLR was notably higher in patients with BMI=30-35 in severe KOA groups. Conclusions: These results suggest that NLR and NMR could provide a new perspective on the relationship between obesity and mild KOA in clinical practice, presenting a cost-effective and easily applicable alternative for determining disease prognosis and progression.

Özet

Amaç: Bu çalışmada, düşük maliyetli, kolay, rutin olarak uygulanan düşük dereceli inflamasyon göstergeleri olan hemogram parametreleri ile obezite ve diz osteoartriti (DOA) şiddeti arasındaki ilişkinin araştırılması amaçlanmıştır. Materyal ve Metot: Bu çalışmaya, diz grafileri, kilo ve boy ölçümleri ve rutin laboratuvar testleri yapılmış 45-85 yaş arası 140 KOA hastası dahil edilmiştir. Kaydedilen veriler demografik bilgileri (cinsiyet, yaş), vücut kitle indeksini (BMI), rutin hemogramı ve laboratuvar parametrelerini içeriyordu. Hastalar Kellgren-Lawrence (KL) skorlarına göre iki gruba (hafif: KL 1-3, şiddetli: KL 4) ve BMI'larına göre dört gruba (BMI 35) ayrılmıştır. Bulgular: Bu çalışmada, serum CRP ve NLR değerleri şiddetli DOA hastalarında hafif DOA hastalarına kıyasla anlamlı derecede yüksek bulunmuştur (P 30 olan hastalarda istatistiksel olarak anlamlı şekilde artmıştır. Ayrıca, şiddetli DOA gruplarında ortalama kan NLR değeri VKİ=30-35 olan hastalarda diğer gruplara kıyasla anlamlı derecede yüksek bulunmuştur. Sonuç: Bu sonuçlar, NLR ve NMR'nin klinik ortamda obezite ve hafif DOA arasındaki ilişkiye yeni bir bakış açısı sağlayabileceğini göstermektedir. Bu parametrelerin düşük maliyetli ve kolay uygulanabilmesi, hastalığın prognozunu ve seyrini belirlemede alternatif olabilir.

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Cite This Article

Gundogdu, K., Gündoğdu, G., Kurtoğlu, A. (2024). Association of Hemogram Parameters with Body Mass Index in Knee Osteoarthritis. Online Türk Sağlık Bilimleri Dergisi, Cilt: 9 Sayı: 3, 202–208. https://doi.org/10.26453/otjhs.1410851

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