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Journals / Eurasian Journal of Medicine and Oncology / 2019 / Cilt: 3 - Sayı: 2

Occupational Exposure Reducing Remedies in Oncology Units

Metin Deniz KARAKOÇ
BURCU YAPAR TAŞKÖYLÜ
Pages
108–111
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: In the study, it has been shown that by making rational choices about drug usage can reduce the healthcare workers duration of exposure to the cytotoxic agents.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The aim of our study is reducing the healthcare workers’ duration of exposure to the cytotoxic agents without increasing the unused dose wasting during preparation by making changes in vial sizes of cytotoxic drugs.
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Key Findings & Data:Results: The total preparation period in the first trimester was 1407 minutes while it was 1058 minutes in the second trimester.
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Conclusion & Impact:Conclusion: In the study, it has been shown that by making rational choices about drug usage can reduce the healthcare workers duration of exposure to the cytotoxic agents.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objectives: The aim of our study is reducing the healthcare workers’ duration of exposure to the cytotoxic agents without increasing the unused dose wasting during preparation by making changes in vial sizes of cytotoxic drugs. Methods: Wasted doses and preparation time (potential exposure time) of the selected antineoplastic drugs were measured for six months. The usage of small dose vials which causes prolongation in preparation time has been avoided and larger dosage forms were preferred in last trimester. Wasted drug dose amounts and preparation periods were recorded. Subsequently, the data compared between the trimesters. Results: The total preparation period in the first trimester was 1407 minutes while it was 1058 minutes in the second trimester. There was no significant changes between the first and the last trimester of the study in terms of patients numbers that receiving chemotherapy and the rate of unused drug doses extermination (p>0.05). On the other hand, drug preparation time, in other words the health employee's exposure period to cytotoxic drugs was reduced 24.81%. Conclusion: In the study, it has been shown that by making rational choices about drug usage can reduce the healthcare workers duration of exposure to the cytotoxic agents.

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Cite This Article

KARAKOÇ, M. D., TAŞKÖYLÜ, B. Y. (2019). Occupational Exposure Reducing Remedies in Oncology Units. Eurasian Journal of Medicine and Oncology, Cilt: 3 - Sayı: 2, 108–111. https://ajindex.com/articles/129128

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References (13)

  1. Giuliani CM, Dass CR. Autophagy and cancer: taking the 'toxic' out of cytotoxics. J Pharm Pharmacol 2013;65:777–89
  2. Martin PL. Safety Pharmacology of Anticancer Agents. Handb Exp Pharmacol 2015;229:405–31
  3. Meade E. Avoiding accidental exposure to intravenous cytotoxic drugs. Br J Nurs 2014;23:S34,S36–9
  4. Kopp B, Schierl R, Nowak D. Evaluation of working practices and surface contamination with antineoplastic drugs in outpatient oncology health care settings. Int Arch Occup Environ Health 2013;86:47–55
  5. Queruau Lamerie T, Nussbaumer S, Décaudin B, Fleury-Sou verain S, Goossens JF, Bonnabry P, et al. Evaluation of decontamination efficacy of cleaning solutions on stainless steel and glass surfaces contaminated by 10 antineoplastic agents. Ann Occup Hyg 2013;57:456–69
  6. Ramphal R, Bains T, Vaillancourt R, Osmond MH, Barrowman N. Occupational exposure to cyclophosphamide in nurses at a single center. J Occup Environ Med 2014;56:304–12
  7. Villarini M, Dominici L, Piccinini R, Fatigoni C, Ambrogi M, Curti G, et al. Assessment of primary, oxidative and excision repaired DNA damage in hospital personnel handling antineoplastic drugs. Mutagenesis 2011;26:359–69
  8. Sottani C, Porro B, Imbriani M, Minoia C. Occupational exposure to antineoplastic drugs in four Italian health care settings. Toxicol Lett 2012;213:107–15
  9. Sugiura S, Nakanishi H, Asano M, Hashida T, Tanimura M, Hama T, et al. Multicenter study for environmental and biological monitoring of occupational exposure to cyclophosphamide in Japan. J Oncol Pharm Pract 2011;17:20–8
  10. El-Ebiary AA, Abuelfadl AA, Sarhan NI. Evaluation of genotoxicity induced by exposure to antineoplastic drugs in lymphocytes of oncology nurses and pharmacists. J Appl Toxicol 2013;33:196–201
  11. Mahmoodi M, Soleyman-Jahi S, Zendehdel K, Mozdarani H, Azimi C, Farzanfar F, et al. Chromosomal aberrations, sister chromatid exchanges, and micronuclei in lymphocytes of oncology department personnel handling anti-neoplastic drugs. Drug Chem Toxicol 2017;40:235–240
  12. Villarini M, Gianfredi V, Levorato S, Vannini S, Salvatori T, Moretti M. Occupational exposure to cytostatic/antineoplastic drugs and cytogenetic damage measured using the lymphocyte cytokinesis-block micronucleus assay: A systematic review of the literature and meta-analysis. Mutat Res 2016;770(Pt A):35–45
  13. Biró A, Fodor Z, Major J, Tompa A. Immunotoxicity monitoring of hospital staff occupationally exposed to cytostatic drugs. Pathol Oncol Res