Journals / Sakarya Tıp Dergisi / 2026 / Volume: 1 Issue: 2

Daily Variation of Free PSA/Total PSA Ratio

Serbest PSA/Total pSA Oranının Günlük Varyasyonu

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Publication Date
2011-06-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The difference between the first and the second calculations were significant and between the first and the third as well (p

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: To determine if there is a different daily variation of freePSA(fPSA), having a distinct metabolic pathway other than tPSA and if any, to understand an ultimate fPSA/tPSA ratio fluctuations that might influence a desicion of biopsy for borderline f/t PSA values.Material and Method: Blood samples were drawn from 33 men with a mean age of 61 years ( 40-84) hospitalized at departments other than urology with different diagnoses, three times a day; morning, afternoon and midnight, with 8 hours intervals, and assayed for fPSA and tPSA.
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Key Findings & Data:Then f/t PSA calculations were made and the data were analyzed statistically.Results: While In 64% of the patients tPSA decreased all the day, fPSA increased in the second calculations and slightly decreased later. f/tPSA value changed from 20% in the morning to 22% and 23% in the afternoon and midnight respectively.
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Conclusion & Impact:The difference between the first and the second calculations were significant and between the first and the third as well (p
🔬Design:Article
📍Scope:Comprehensive Sample
⚙️Variables:FreePSA · totalPSA · daily variation.

Abstract

Purpose: To determine if there is a different daily variation of freePSA(fPSA), having a distinct metabolic pathway other than tPSA and if any, to understand an ultimate fPSA/tPSA ratio fluctuations that might influence a desicion of biopsy for borderline f/t PSA values.Material and Method: Blood samples were drawn from 33 men with a mean age of 61 years ( 40-84) hospitalized at departments other than urology with different diagnoses, three times a day; morning, afternoon and midnight, with 8 hours intervals, and assayed for fPSA and tPSA. Then f/t PSA calculations were made and the data were analyzed statistically.Results: While In 64% of the patients tPSA decreased all the day, fPSA increased in the second calculations and slightly decreased later. f/tPSA value changed from 20% in the morning to 22% and 23% in the afternoon and midnight respectively. The difference between the first and the second calculations were significant and between the first and the third as well (p

Özet

Giriş: Total PSA(tPSA)'dan farklı bir metabolizmaya sahip olan serbest PSA(sPSA)'nın, tPSA'dan farklı bir günlük varyasyonunun olup olmadığını; varsa, serbest/total PSA oranının gün içinde değişip değişmediğini araştırmak istedik. Materyal ve Metod: Yaş ortalaması 61( 40-84 arası) olan ve üroloji dışında diğer kliniklerde yatan 33 erkek hastadan 8 saat arayla 3 kez kan alınarak aynı anda serbest ve total PSA değerlerine bakıldı. Her üç ölçüm için s/t PSA değerleri hesaplandı ve sonuçlar istatistik olarak değerlendirildi.Bulgular: 33 hastanın %64'ünde tPSA gün içinde gittikçe düşerken bu esnada ölçülen serbest PSA değerleri önce yükselip sonra hafif azalmış; sabah %20 olan s/t PSA oranı öğleden sonra %22 ve gece %23 olarak hesaplanmıştır. İkinci ve üçüncü hesaplamaların ilkine göre anlamlı (p

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Cite This Article

Sağlam, H. S., Özdemir, F. (2011). Daily Variation of Free PSA/Total PSA Ratio. Sakarya Tıp Dergisi, Volume: 1 Issue: 2. https://doi.org/10.5505/sakaryamj.2011.30502

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