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Journals / Sakarya Tıp Dergisi / 2026 / Volume: 8 Issue: 2

Hidden Blood Loss, Infection and Cost-Effectiveness of Tranexamic Acid Protocol in Primary Total Knee Arthroplasty

Hakkı Çağdaş Basat(Ahi Evran University, Turkey)0000-0003-3301-2529
Berk Güçlü(UFUK ÜNİVERSİTESİ)0000-0002-3705-3435
Ömer Bozduman(Afyonkarahisar State Hospital)0000-0002-8392-1846
Yasin Köker0000-0002-8392-1846
Cihan Kırçıl0000-0001-9758-5778
Hicabi Sezgin0000-0002-1332-3656
Pages
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Publication Date
2018-06-29
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Conclusion: Combined topical and continuous up to 24 hours intravenous administration of TXA reduced the total blood loss and decreased drainage volume, as well as reducing hidden blood loss.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The purpose was to evaluate the effect of combined administration of TXA on total blood loss, hidden blood loss, drain output, cost effectiveness and periprosthetic infection rate in patients undergoing unilateral primary knee arthroplasty.
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Key Findings & Data:Materials and Methods: We enrolled fifty-eight patients with primary gonarthrosis undergoing unilateral primary knee arthroplasty between May 2014 and December 2014.
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Conclusion & Impact:Conclusion: Combined topical and continuous up to 24 hours intravenous administration of TXA reduced the total blood loss and decreased drainage volume, as well as reducing hidden blood loss.
🔬Design:Research Article
📍Scope:2014 Verileri
⚙️Variables:Blood loss · Hidden loss · Tranexamic acid

Abstract

Objective: The purpose was to evaluate the effect of combined administration of TXA on total blood loss, hidden blood loss, drain output, cost effectiveness and periprosthetic infection rate in patients undergoing unilateral primary knee arthroplasty. Materials and Methods: We enrolled fifty-eight patients with primary gonarthrosis undergoing unilateral primary knee arthroplasty between May 2014 and December 2014. We compared 29 cases performed without the application of TXA to 29 cases performed with the application of TXA. Our TXA protocol consisted of three stages. Results: Postoperative hemoglobin and hematocrit levels were found to be significantly lower in the non-TXA group. Estimated blood loss, hidden blood loss, and drain output were found to be higher in the non-TXA group. Transfusion rate was lower in TXA group. The blood bank costs were found to be higher in the non-TXA group. The total direct cost was also higher in the non-TXA group. This was average 29.9$ savings per case in the TXA group. No complication such as infection or thromboemboli was detected among the study groups. Conclusion: Combined topical and continuous up to 24 hours intravenous administration of TXA reduced the total blood loss and decreased drainage volume, as well as reducing hidden blood loss.

Özet

Objective: The purpose was to evaluate the effect of combined administration of TXA on total blood loss, hidden blood loss, drain output, cost effectiveness and periprosthetic infection rate in patients undergoing unilateral primary knee arthroplasty. Materials and Methods: We enrolled fifty-eight patients with primary gonarthrosis undergoing unilateral primary knee arthroplasty between May 2014 and December 2014. We compared 29 cases performed without the application of TXA to 29 cases performed with the application of TXA. Our TXA protocol consisted of three stages. Results: Postoperative hemoglobin and hematocrit levels were found to be significantly lower in the non-TXA group. Estimated blood loss, hidden blood loss, and drain output were found to be higher in the non-TXA group. Transfusion rate was lower in TXA group. The blood bank costs were found to be higher in the non-TXA group. The total direct cost was also higher in the non-TXA group. This was average 29.9$ savings per case in the TXA group. No complication such as infection or thromboemboli was detected among the study groups. Conclusion: Combined topical and continuous up to 24 hours intravenous administration of TXA reduced the total blood loss and decreased drainage volume, as well as reducing hidden blood loss.

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Cite This Article

Basat, H. Ç., Güçlü, B., Bozduman, Ö., Köker, Y., Kırçıl, C., Sezgin, H. (2018). Hidden Blood Loss, Infection and Cost-Effectiveness of Tranexamic Acid Protocol in Primary Total Knee Arthroplasty. Sakarya Tıp Dergisi, Volume: 8 Issue: 2. https://doi.org/10.31832/smj.420189

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