Journals / Sakarya Tıp Dergisi / 2026 / Volume: 9 Issue: 3

Xanthogranulomatous Cholecystitis: A Case Report

Selma Erdoğan Düzcü(BOLU ABANT İZZET BAYSAL ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-6768-1275
Roni Kazazi(BOLU ABANT İZZET BAYSAL ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-3436-2539
Pages
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Publication Date
2019-09-16
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This case report describes clinical, radiologic and pathologic findings of a patient diagnosed with XGC.

📌 3 Key Takeaways

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Objective & Hypothesis:Xanthogranulomatous cholecystitis (XGC) is a benign, rare seen chronic inflammation of gallbladder as the result of destruction of the mucosa of the gallbladder and infiltration of macrophages inside the gallbladder wall.
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Key Findings & Data:It was first described in 1970 as ‘’fibroxanthogranulomatous cholecystitis’’ by Christensen and Ishak.
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Conclusion & Impact:This case report describes clinical, radiologic and pathologic findings of a patient diagnosed with XGC.
🔬Design:Case Report
📍Scope:Comprehensive Sample
⚙️Variables:Xanthogranulomatous Cholecystitis · Cholelithiasis · Gallbladder

Abstract

Xanthogranulomatous cholecystitis (XGC) is a benign, rare seen chronic inflammation of gallbladder as the result of destruction of the mucosa of the gallbladder and infiltration of macrophages inside the gallbladder wall. It was first described in 1970 as ‘’fibroxanthogranulomatous cholecystitis’’ by Christensen and Ishak. The major preoperative radiologic finding of XGC is thickening of the gallbladder wall (>4mm) and its importance lies in the fact that XGC mimics the gallbladder carcinoma as it does not express a unique finding in either radiologic or clinical findings, leading to unnecessary enlarged resections due surgeries. The final diagnosis is usually made during microscopic examination in pathology. This case report describes clinical, radiologic and pathologic findings of a patient diagnosed with XGC.

Özet

Ksantogranülomatöz kolesistit (XGC) ender görülen ve iyi huylu kronik bir safra kesesi enflamasyonu olup, genelde mukoza zedelenmesi sonrasında makrofajların safra kesesi duvarına infiltrasyon göstermesi sonucu meydana gelir. İlk olarak 1970 yılında ‘fibroksantogranülomatöz kolesistit’ olarak Christenser ve Ishak tarafından tanımlanmıştır. Radyolojik olarak safra kesesinde duvar kalınlaşması (>4 mm) görülmesi nedeniyle, safra kesesi tümörlerini yapı ve morfolojik görüntüsü ile taklit etmesi açısından tanısı önem taşımaktadır. XGC'e spesifik bir radyolojik veya klinik bulgu bulunamadığı için cerrahi işlemler esnasında gereksiz ve genişletilmiş organ rezeksyonları yapılmaktadır. Kesin tanı patolojide mikroskopik inceleme sonucu ortaya konur. Bu olgu sunumunda XGC tanısı almış bir vakanın klinik, radyolojik ve patolojik bulguları sulumuştur.

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Cite This Article

Düzcü, S. E., Kazazi, R. (2019). Xanthogranulomatous Cholecystitis: A Case Report. Sakarya Tıp Dergisi, Volume: 9 Issue: 3. https://doi.org/10.31832/smj.533361

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