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Journals / Sakarya Tıp Dergisi / 2026 / Volume: 9 Issue: 3

Knee Arthropathy and Bilateral Total Knee Arthroplasty Ratio in Hemophilia A Patients

Hemofili A Hastalarındaki Diz Artropatisi ve Bilateral Total Diz Artroplastisi Oranı

Levent Bayam(SAKARYA ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-5149-0829
Justine Theaker(Manchester University Hospitals)0000-0001-5223-2944
Sanat V Shah(Manchester University Hospitals)0000-0002-0981-1155
Pages
—
Publication Date
2019-09-16
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These results show the importance of patient care in this group of patients, close follow-up and prophylactic treatment.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This epidemiological study was co nducted in the joint haematology- orthopaedics clinic of a university hospital.
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Key Findings & Data:Materials and Method: This was a retrospective stu dy 49 patients with knee problems out of 130 haemophilia A and musc u loskeletal problems .
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Conclusion & Impact:These results show the importance of patient care in this group of patients, close follow-up and prophylactic treatment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:HemophiliaA · Total knee arthroplasty · Bilateral

Abstract

Objective: This epidemiological study was co nducted in the joint haematology- orthopaedics clinic of a university hospital. The aim was to analyse the data in terms of age and radiolo gy of patients with moder ate or severe haemophilia A and knee involvement. Materials and Method: This was a retrospective stu dy 49 patients with knee problems out of 130 haemophilia A and musc u loskeletal problems . Kellgren-Lawrence (KL) classification was used for radiological assessments of osteoarthritis degree. Results: KL degree was 3 or 4 for most patients (27/39, 69.23%) in the group. There was statistically a meaningful correlation between KL degree and patients’ age (Spearman’s: r s = 0.512, p = 0.001). There were 7 patients with KL degree 4 at the age of 50 or younger (14.29%). 25 patients in 49 (51.0 2%) had total knee arthroplasty(TKA) and 10(40%) of those was bilateral . Mea n age for bilateral TKA (56.3 5 ) was higher than unilateral(49.87 ). There was a statistically mea ningful correlation between patient age and the patients with TKA (Spearman’s : r s = 0.338, p = 0.017 ). There were 2 revision surgeries out of 35 TKA (5.7 1 %). Most of the patients had prophyl actic factor treatment (43, 87.75 %). Conclusion: Our study signify the high ratio of bilateral knee replacements in haemophilia A patients and how early age they progressed to KL stage 4 comparing to normal population. These results show the importance of patient care in this group of patients, close follow-up and prophylactic treatment. They should be managed in experienced centres by an experience team to decrease the risks and complications.

Özet

Amaç: Hemofili hastalarında epidemiyolojik olarak yapılan çalışmamızda, bir üniversite hastanesinin hematoloji-ortopedi ortak kayıtları kullanıldı. Bu çalışmanın amacı, diz problemleri olan orta ve ağır hemofili hastalarından elde edilen bilgileri, hastaların yaşı ve radyolojik açısından degerlendirmekti. Gereç ve Yöntemler: Retrospektif bir çalışma olup, iskelet-kas sistemi problemleri olan 130 hemofili A hastasından diz problemli 49’u bu çalısmaya dahil edildi. Kellgren-Lawrence(KL) sınıflaması, osteoartritlerin radyolojik degerlendirmesinde kullanıldı. Elektronik datalardan elden edilen bilgiler, sonuçları analiz etmek ve istatistiksel degerlendirmeler icin kullanıldı. Bulgular: Düz diz grafiği çekilmiş hastaların çoğunluğunda (27/39, %69,23), KL derecesi 3 veya 4 idi. KL derecesi ile hastaların yaşları arasında istatistiksel olarak anlamlı bir korelasyon mevcut idi (Spearman’s : r s = 0,512, p (2-tailed) = 0,001). Ayrıca, KL derecesi 4 olan 50 yas ve altında 7 hasta (%14,29) vardı. 4 9 diz problemi olan hastanın 25’ inde (%51.02) total diz artroplasti (TDA) yapıldı ve bunların da 10 tanesi (%40) bilateral idi. Bilateral TDA icin ortalama yas (56.3 5 ), unilateral TDA dan (49.87) daha yüksek di. Hastaların yaşı ile TDA olmaları arasında istatistiksel olarak anlamlı bir korelasyon vardi (Spearman’s: r s = 0,338, p = 0,017). 35 TDA yapılan hastada 2 revizyon tesbit edildi (%5.71). ç alışmaya dahil edilen h astaların ç ogu (43/49 , %87.75), profilaktik faktör tedavisi almaktaydı Sonu ç : Çalışmamız , hemofili A hastalarındaki yüksek bilateral TDA oranını ve normal popülasyona gore bu grubunun ne kadar erken yasta KL 4 safhasına ilerlediklerini vurgulamaktadır. Bu sonuclar bize, bu grup hastalardaki tedavi yaklaşımının, yakin ta kibin ve profilaksinin önemini göstermektedir. Bu ha s talardaki risk ve komplikasyonları azaltmak icin, tedavileri, tecrübeli merkezlerde ve özelleşmiş bir grup tarafından yapılmalıdır.

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Cite This Article

Bayam, L., Theaker, J., Shah, S. V. (2019). Knee Arthropathy and Bilateral Total Knee Arthroplasty Ratio in Hemophilia A Patients. Sakarya Tıp Dergisi, Volume: 9 Issue: 3. https://doi.org/10.31832/smj.573074

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