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Journals / Sakarya Tıp Dergisi / 2021 / Volume: 11 Issue: 4

How do levels of ferritin, fibrinogen and procalcitonin affect the clinical course of COVID-19 in pregnant women?

Ferritin, fibrinojen ve prokalsitonin düzeyleri gebelerde COVID-19 klinik seyrini nasıl etkiler?

Huri Güvey(Serbest hekim)0000-0002-8603-6981
Canan Soyer Çalışkan(Samsun Eğitim ve Araştırma Hastanesi)0000-0002-9889-5249
Samettin Çelik(Samsun Eğitim ve Araştırma Hastanesi)0000-0002-6407-1129
Merve Yılmaz(Samsun Gazi Devlet Hastanesi)0000-0002-3421-8548
Zehra Yılmaz(Serbest hekim)0000-0003-1162-8648
Pages
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Publication Date
2021-12-27
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Fibrinogen may be an indicator of the severity of the COVID-19 clinical course in pregnant women, but prospective, follow-up studies with larger samples are required to reinforce this finding.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Coronavirus disease 2019 (COVID 19) is a pandemic affecting pregnant women as well as lots of people.
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Key Findings & Data:The aim of our study is to investigate the effects of inflammatory markers on the course of COVID-19 in pregnant women.
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Conclusion & Impact:Fibrinogen may be an indicator of the severity of the COVID-19 clinical course in pregnant women, but prospective, follow-up studies with larger samples are required to reinforce this finding.
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:COVID-19 · pregnancy · fibrinogen

Abstract

Objective: Coronavirus disease 2019 (COVID 19) is a pandemic affecting pregnant women as well as lots of people. The aim of our study is to investigate the effects of inflammatory markers on the course of COVID-19 in pregnant women. Materials and methods: In this cross-sectional descriptive study, which included 125 pregnant women who were positive for Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 40 women who were negative, patients with COVID-19 were grouped as mild, moderate, and severe according to oxygen saturation, lung involvement findings. Fibrinogen, ferritin, and procalcitonin values of the participants were compared. Results: While there was no significant difference between the ferritin (p = 0,241) and procalcitonin (p = 0,579) values of pregnant women according to the SARS-CoV-2 status, the fibrinogen values of pregnant women with positive test were found to be significantly higher (p<0,001). When we categorize the participants who are positive for SARS-CoV-2 as mild, moderate, and severe; a significant difference was found between fibrinogen (p<0,001) values. In paired comparison, the fibrinogen value of the group with mild disease was found to be significantly lower than the group with moderate (p<0,001) and severe (p<0,001), and the group with a moderate disease compared to the group with severe (p = 0,007). Conclusion: We found that as the severity of the disease increased, fibrinogen levels also increased. Fibrinogen may be an indicator of the severity of the COVID-19 clinical course in pregnant women, but prospective, follow-up studies with larger samples are required to reinforce this finding.

Özet

Amaç: Coronavirus Disease 2019 (COVID-19) birçok insanı olduğu kadar gebeleri de etkileyen bir pandemidir. Çalışmamızın amacı inflamatuar belirteçlerin gebelerde COVID-19 seyrine etkisini araştırmaktır. Gereç ve yöntem: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pozitif olan 125 ve negatif olan 40 gebenin dahil edildiği bu kesitsel tipe tanımlayıcı çalışmada, COVID-19 olan hastalar oksijen satürasyonu, akciğer tutulumu bulgularına göre hafif orta ve ağır olarak gruplandırılmıştır. Fibirnojen, ferritin ve prokalsitonin değerleri karşılaştırılmıştır. Bulgular: SARS-CoV-2 durumuna göre gebelerin ferritin (p=0,241) ve prokalsitonin (p=0,579) değerleri arasında da anlamlı fark saptanmazken, testi pozitif gebelerin fibrinojen değerleri anlamlı olarak yüksek bulunmuştur (p<0,001). SARS-CoV-2 pozitif olan katılımcıları kendi içerisinde klinik durumuna hafif, orta ve ağır olarak gruplandırıp baktığımızda ise; fibrinojen (p<0,001) değerleri arasında anlamlı fark saptanmıştır. İkili karşılaştırmada klinik seyri hafif olan grupta fibrinojen değeri orta (p<0,001) ve ağır (p<0,001) olan gruptan, klinik seyri orta olan grubun fibrinojen değeri ise ağır olan gruptan anlamlı olarak düşük saptanmıştır (p=0,007) Sonuç: Hastalığın ağırlığı arttıkça fibrinojen seviyelerinin de arttığını tespit ettik. Fibrinojen gebelerde COVID-19 klinik durumunun ağırlığı ile ilgili bir gösterge olabilir ancak bu bulguyu güçlendirmek için daha büyük örnekleme sahip prospektif, izleme dayalı çalışmalar gerekmektedir.

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Cite This Article

Güvey, H., Çalışkan, C. S., Çelik, S., Yılmaz, M., Yılmaz, Z. (2021). How do levels of ferritin, fibrinogen and procalcitonin affect the clinical course of COVID-19 in pregnant women?. Sakarya Tıp Dergisi, Volume: 11 Issue: 4. https://doi.org/10.31832/smj.932304

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