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Journals / Sakarya Tıp Dergisi / 2026 / Volume: 15 Issue: 3

The Clinical Role of the Thiol-Disulfide Balance as an Oxidative Stress Indicator in Patients with Obesity

Soner Yeşilyurt(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL TAKSİM SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ)0000-0002-0739-8344
Osman Erinç(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KANUNİ SULTAN SÜLEYMAN SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ)0000-0002-8676-0136
Türker Demirtakan(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL TAKSİM SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-4075-5518
Almila Şenat(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL TAKSİM SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-5806-562X
Esra Fırat Oğuz(YILDIRIM BEYAZIT ÜNİVERSİTESİ)0000-0002-8147-5379
Nihat Mujdat Hokenek(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL BAŞAKŞEHİR ÇAM VE SAKURA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, ACİL TIP ANABİLİM DALI)0000-0002-8780-572X
Özcan Erel(YILDIRIM BEYAZIT ÜNİVERSİTESİ)0000-0002-2996-3236
Pages
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Publication Date
2025-09-30
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Reduced native and total thiol levels, along with altered disulfide concentrations in obese individuals, serve as indicators of oxidative stress.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Thiol-disulfide measurements will assess obesity-related oxidative stress.
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Key Findings & Data:The participants were divided into three distinct categories based on their body mass index (BMI): The control group (Group 1) consisted of 116 individuals with a BMI ranging from 18 to 25 kg/m², while the overweight group (Group 2, n = 89) included those with a BMI between 25 and 30 kg/m².
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Conclusion & Impact:Conclusions: Reduced native and total thiol levels, along with altered disulfide concentrations in obese individuals, serve as indicators of oxidative stress.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:thiol disulfide balance · inflammatory markers · oxidative stress

Abstract

Objectives: Thiol-disulfide measurements will assess obesity-related oxidative stress. Methods: A prospective observational study was done at two tertiary care centers. The participants were divided into three distinct categories based on their body mass index (BMI): The control group (Group 1) consisted of 116 individuals with a BMI ranging from 18 to 25 kg/m², while the overweight group (Group 2, n = 89) included those with a BMI between 25 and 30 kg/m². The obese group (Group 3, n = 39) comprised individuals with a BMI of 30 kg/m² or greater. This approach primarily utilizes the disulfide/native thiol ratio, disulfide/total thiol ratio, and native thiol/total thiol ratio as key metrics. All patients' demographics, waist circumference, hip circumference, height, weight, hemoglobin, hematocrit, white blood cell count, glucose, C-reactive protein, disulfide, native-thiol (NT), total-thiol (TT), lipid hydroperoxide radical (LOOH), and absolute ischemia-modified-albumin (ABSO) levels were recorded on calculations and records were made for disulfide to native and total thiol ratios. Results: Thiol-disulfide equilibrium differed between the three groups. NT concentrations averaged 368.87 mmol/L across all individuals and were significantly higher in the normal-weight cohort (BMI 18-25 kg/m2) at 380.60 mmol/L, compared to overweight and obese populations (p<0.001). TT concentrations were higher in normal-weight individuals, with an average of 426.36±54.48 mmol/L, compared to 405.41±52.14 and 391.07±46.45 in overweight and obese individuals, respectively (p<0.001). Conclusions: Reduced native and total thiol levels, along with altered disulfide concentrations in obese individuals, serve as indicators of oxidative stress.

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Cite This Article

Yeşilyurt, S., Erinç, O., Demirtakan, T., Şenat, A., Oğuz, E. F., Hokenek, N. M., Erel, Ö. (2025). The Clinical Role of the Thiol-Disulfide Balance as an Oxidative Stress Indicator in Patients with Obesity. Sakarya Tıp Dergisi, Volume: 15 Issue: 3. https://doi.org/10.31832/smj.1698739

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