Journals / Sakarya Tıp Dergisi / 2026 / Volume: 15 Issue: 3

Evaluation of Cardiorenal Metabolic Syndrome in Patients with Heart Failure with Preserved Ejection Fraction. How Aware Are We?

Hüseyin Ali Öztürk(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ADANA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0001-5713-004X
Erdinc Gulumsek(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ADANA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0003-0026-2396
Dilan Damla Ozturk(Yüreğir Devlet Hastanesi İç Hastalıkları Kliniği)0000-0001-7418-5851
Fatih Necip Arıcı(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ADANA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-1160-2125
Cigdem Erhan(Seyhan Devlet Hastanesi İç Hastalıkları Kliniği)0009-0003-4736-5699
Bektaş Işık(Yayladağı Devlet Hastanesi İç Hastalıkları Kliniği)0000-0001-9553-722X
Mehmet Can Erişen(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ADANA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0009-0006-1976-2787
Berçem Berent Kaya(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ADANA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0009-0006-5476-4470
Ugur Can Izlimek(5 Ocak Devlet Hastanesi İç Hastalıkları Kliniği)0000-0002-6316-5369
Cahit Dincer(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL SULTAN ABDÜLHAMİD HAN SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0001-5428-895X
Ahmet Gazi Mustan(Karaisali Devlet Hastanesi İç Hastalıkları Kliniği)0000-0002-9784-5063
Çisem Yılmaz(Osmaniye Devlet Hastanesi İç Hastalıkları Kliniği)0000-0002-7140-1165
Tayyibe Saler(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ADANA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0001-5588-5609
Hilmi Erdem Sümbül(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ADANA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-7192-0280
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Publication Date
2025-09-30
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: We recommend that HFpEF, which is associated with increased cardiovascular mortality and morbidity in patients with CRMD, should be screened clinically and with NT-proBNP and evaluated with transthoracic echocardiography if necessary.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Despite the prevalence of cardiorenal metabolic diseases (CRMD) in heart failure with preserved ejection fraction (HFpEF) patients and their significant complications, they are thought to be under-recognized and under-screened.
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Key Findings & Data:Methods: Our retrospective and cross-sectional study included 348 patients with HFpEF.
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Conclusion & Impact:Conclusion: We recommend that HFpEF, which is associated with increased cardiovascular mortality and morbidity in patients with CRMD, should be screened clinically and with NT-proBNP and evaluated with transthoracic echocardiography if necessary.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:CRMD · Diabetes mellitus · HFpEF

Abstract

Aim: Despite the prevalence of cardiorenal metabolic diseases (CRMD) in heart failure with preserved ejection fraction (HFpEF) patients and their significant complications, they are thought to be under-recognized and under-screened. In our study, we aimed to evaluate patients with HFpEF who were followed up in our internal medicine clinic. Methods: Our retrospective and cross-sectional study included 348 patients with HFpEF. Patients were evaluated according to laboratory, demographic, clinical, electrocardiographic and ultrasonographic findings. Results: Of the patients, 37.95% had diabetes mellitus, 23.3% had chronic kidney disease, 70.1% had hypertension and 59.2% had metabolic dysfunction-associated steatotic liver disease. The mean NT-proBNP level was 360.7 ± 13.7. Conclusion: We recommend that HFpEF, which is associated with increased cardiovascular mortality and morbidity in patients with CRMD, should be screened clinically and with NT-proBNP and evaluated with transthoracic echocardiography if necessary.

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Cite This Article

Öztürk, H. A., Gulumsek, E., Ozturk, D. D., Arıcı, F. N., Erhan, C., Işık, B., Erişen, M. C., Kaya, B. B., Izlimek, U. C., Dincer, C., Mustan, A. G., Yılmaz, Ç., Saler, T., Sümbül, H. E. (2025). Evaluation of Cardiorenal Metabolic Syndrome in Patients with Heart Failure with Preserved Ejection Fraction. How Aware Are We?. Sakarya Tıp Dergisi, Volume: 15 Issue: 3. https://doi.org/10.31832/smj.1684457

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