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Journals / Sakarya Tıp Dergisi / 2026 / Volume: 15 Issue: 4

Combined Therapy Superior to Monotherapy in Overactive Bladder Patients with Pelvic Organ Prolapse: A Retrospective Comparative Study

Hacı Can Direk(Mersin Su Hospital)0000-0002-4575-512X
Anıl Erdik(Sakarya Karasu State Hospital, Department of Urology)0000-0002-5132-7447
Hacı İbrahim Çimen(SAKARYA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, THE DEPARTMENT OF UROLOGY)0000-0002-0824-3926
Deniz Gül(SAKARYA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, THE DEPARTMENT OF UROLOGY)0000-0003-0873-0000
Yavuz Tarık Atik(Department of Urology, Medstar Antalya Hospital)0000-0002-6398-8410
Osman Köse(SAKARYA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, THE DEPARTMENT OF UROLOGY)0000-0002-1053-3551
Pages
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Publication Date
2025-12-20
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Behavioral monotherapy may be more effective than anticholinergic alone, supporting multimodal approaches as first-line management.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To compare short-term outcomes of behavioral, anticholinergic, and combined therapies in overactive bladder (OAB) patients with pelvic organ prolapse (POP).
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Key Findings & Data:Methods: This single-center retrospective study included 90 women with OAB and POP (POP-Q stage ≤2) categorized as: Group 1 (behavioral therapy; n=30), Group 2 (anticholinergic therapy; n=30), and Group 3 (combined therapy; n=30).
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Conclusion & Impact:Behavioral monotherapy may be more effective than anticholinergic alone, supporting multimodal approaches as first-line management.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Anticholinergic · Combined treatment · Conservative treatment

Abstract

Objective: To compare short-term outcomes of behavioral, anticholinergic, and combined therapies in overactive bladder (OAB) patients with pelvic organ prolapse (POP). Methods: This single-center retrospective study included 90 women with OAB and POP (POP-Q stage ≤2) categorized as: Group 1 (behavioral therapy; n=30), Group 2 (anticholinergic therapy; n=30), and Group 3 (combined therapy; n=30). Validated questionnaires (IIQ-7, UDI-6, OAB-V8, ICIQ-SF) were used to assess symptom severity and quality of life (QoL) pre- and post-treatment. Statistical analyses employed ANOVA and paired t-tests, with p<0.05 considered significant. Results: All groups showed significant improvement in all questionnaires post-treatment (p<0.05), except UDI-6 in Groups 1 and 2. Combined therapy (Group 3) achieved the greatest reductions in scores: ICIQ-SF: (Δ10.74), IIQ-7: (Δ4.57), OAB-V8: (Δ4.31). Behavioral therapy (Group 1) outperformed anticholinergic therapy alone (Group 2) in symptom reduction (IIQ-7: Δ4.69 vs. Δ2.55; OAB-V8: Δ2.83 vs. Δ3.62; both p<0.05). Daily pad usage differed significantly among groups (Group 1: 2.2±1.4; Group 2: 3.1±0.8; Group 3: 4.3±1.3; p<0.001). Conclusion: While all therapies improved OAB symptoms, combined behavioral-pharmacological therapy demonstrated superior efficacy in reducing symptom severity and enhancing QoL in patients with concomitant POP. Behavioral monotherapy may be more effective than anticholinergic alone, supporting multimodal approaches as first-line management.

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Cite This Article

Direk, H. C., Erdik, A., Çimen, H. İ., Gül, D., Atik, Y. T., Köse, O., *, A. E. (2025). Combined Therapy Superior to Monotherapy in Overactive Bladder Patients with Pelvic Organ Prolapse: A Retrospective Comparative Study. Sakarya Tıp Dergisi, Volume: 15 Issue: 4. https://doi.org/10.31832/smj.1789945

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