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Journals / Sakarya Tıp Dergisi / 2026 / Volume: 16 Issue: 1

Recurrence-Related Factors in Early Stage Endometrial Cancer

Necim Yalçın(BATMAN TRAINING AND RESEARCH HOSPITAL, DEPARTMENT OF GYNECOLOGIC ONCOLOGY)0000-0001-5980-3244
Aysun Alcı(KAHRAMANMARAŞ NECIP FAZIL CITY HOSPITAL, DEPARTMENT OF GYNECOLOGIC ONCOLOGY)0000-0002-7912-7375
Mustafa Gökkaya(GAZİANTEP CITY HOSPITAL, DEPARTMENT OF GYNECOLOGIC ONCOLOGY)0000-0002-0477-157X
Tayfun Toptaş(UNIVERSITY OF HEALTH SCIENCES ANTALYA TRAINING AND RESEARCH HOSPITAL, DEPARTMENT OF GYNECOLOGIC ONCOLOGY)0000-0002-6706-6915
İsin Ureyen(UNIVERSITY OF HEALTH SCIENCES ANTALYA TRAINING AND RESEARCH HOSPITAL, DEPARTMENT OF GYNECOLOGIC ONCOLOGY)0000-0002-3491-4682
Pages
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Publication Date
2026-03-28
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Although surgical type, histological type, and adjuvant therapy were identified as factors associated with recurrence in univariate analyses, there is a need for a detailed examination of these factors through multicenter studies involving larger patient cohorts.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The main objective of this study is to identify clinical and pathological factors associated with recurrence in patients diagnosed with early-stage (stage I–II) endometrial cancer.
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Key Findings & Data:Methods: A total of 98 patients diagnosed with stage I–II endometrial cancer who underwent surgical treatment at a single center between 2017 and 2021 were retrospectively analyzed.
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Conclusion & Impact:Although surgical type, histological type, and adjuvant therapy were identified as factors associated with recurrence in univariate analyses, there is a need for a detailed examination of these factors through multicenter studies involving larger patient cohorts.
🔬Design:Research Article
📍Scope:2017 Verileri
⚙️Variables:Endometrial cancer · Early stage · Recurrence

Abstract

Objective: The main objective of this study is to identify clinical and pathological factors associated with recurrence in patients diagnosed with early-stage (stage I–II) endometrial cancer. Methods: A total of 98 patients diagnosed with stage I–II endometrial cancer who underwent surgical treatment at a single center between 2017 and 2021 were retrospectively analyzed. The patients’ clinical and pathological characteristics, the adjuvant therapies administered, and follow-up outcomes were evaluated. Factors associated with recurrence were assessed using univariate analyses. Results: The mean age of the patients was 59.8 years, and the mean tumor size was 3.58 cm. The mean follow-up period was 49.1 months. The recurrence rate was 8.2%. Five recurrences were identified as locoregional, and three as distant metastases. In univariate analyses, surgical type (p=0.015), adjuvant therapy (p=0.009), and histotype (endometrioid vs. non-endometrioid, p=0.016) were found to be associated with recurrence. Conclusions: The recurrence rate in early-stage endometrial cancer was found to be low, consistent with the literature, and it was determined that 5 of the recurrences were locoregional in nature, while the remaining 3 were distant metastases. Although surgical type, histological type, and adjuvant therapy were identified as factors associated with recurrence in univariate analyses, there is a need for a detailed examination of these factors through multicenter studies involving larger patient cohorts.

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Cite This Article

Yalçın, N., Alcı, A., Gökkaya, M., Toptaş, T., Ureyen, İ. (2026). Recurrence-Related Factors in Early Stage Endometrial Cancer. Sakarya Tıp Dergisi, Volume: 16 Issue: 1. https://doi.org/10.31832/smj.1784654

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