SavedAdd your journal

Journals / Sakarya Tıp Dergisi / 2026 / Volume: 16 Issue: 3

The Effect of BCR-ABL(IS) Levels on Early and Late-Stage Response Rates and Prognosis at the Time of Diagnosis in Patients with Chronic Myeloid Leukemia (CML) in Chronic Phase

Vehbi Demircan(DICLE UNIVERSITY)0000-0002-0378-8687
Abdullah Karakuş(DICLE UNIVERSITY)0000-0003-2090-4392
Songül Beskisiz Dönen(GAZİ YAŞARGİL EDUCATION RESEARCH HOSPITAL, DEPARTMENT OF HEMATOLOGY)0000-0001-9893-3586
Orhan Ayyıldız(DICLE UNIVERSITY)0000-0001-5673-8408
Pages
—
Publication Date
2026-09-30
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, our study found that the BCR-ABL(IS) value at the time of diagnosis is not a predictive factor for prognosis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The BCR-ABL(IS) value plays a crucial role in the prognosis of chronic myeloid leukemia (CML) patients.
📊
Key Findings & Data:The aim of this study was to compare molecular response rates two BCR-ABL(IS) score levels at the time of diagnosis in chronic-phase CML patients.
💡
Conclusion & Impact:However, our study found that the BCR-ABL(IS) value at the time of diagnosis is not a predictive factor for prognosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Chronic Myeloid Leukemia(CML) · BCR-ABL(IS) · Prognosis

Abstract

Objective: The BCR-ABL(IS) value plays a crucial role in the prognosis of chronic myeloid leukemia (CML) patients. The aim of this study was to compare molecular response rates two BCR-ABL(IS) score levels at the time of diagnosis in chronic-phase CML patients. Methods: The study included 104 patients diagnosed with chronic-phase CML at the Hematology Clinic of Dicle University Faculty of Medicine. BCR-ABL(IS) values were measured during the course of the patients' treatment, with a median follow-up period of 42 months. Molecular response rates were assessed at the 3rd, 6th, and 12th months, and long-term follow-up was conducted to evaluate the effect of BCR-ABL(IS) values at diagnosis on patient outcomes. Results: Patients were divided into two groups based on their BCR-ABL(IS) values at diagnosis: 52 patients (50%) had BCR-ABL(IS) values below 75% (median BCR-ABL(IS) = 56.3%), and 52 patients (50%) had BCR-ABL(IS) values above 75% (median BCR-ABL(IS) = 111%). No significant difference was observed between the early (3rd and 6th months) and late (12th month and long-term) optimal response rates between the two groups. Both groups showed similar responses at these time points, indicating that the initial BCR-ABL(IS) value did not significantly impact the response rates or prognosis at the 3rd, 6th, and 12th months, in the long-term follow-up. Conclusions: The prognosis of CML patients is influenced by various factors at diagnosis, including patient characteristics and disease factors. However, our study found that the BCR-ABL(IS) value at the time of diagnosis is not a predictive factor for prognosis.

🔖

Cite This Article

Demircan, V., Karakuş, A., Dönen, S. B., Ayyıldız, O. (2026). The Effect of BCR-ABL(IS) Levels on Early and Late-Stage Response Rates and Prognosis at the Time of Diagnosis in Patients with Chronic Myeloid Leukemia (CML) in Chronic Phase. Sakarya Tıp Dergisi, Volume: 16 Issue: 3. https://doi.org/10.31832/smj.1938436

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (18)

  1. Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM. The biology of chronic myeloid leukemia. N Engl J Med. 1999;341(3):164-72. doi:10.1056/NEJM199907153410306.
  2. O'Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2003;348(11):994-1004. doi:10.1056/NEJMoa022457.
  3. Kantarjian H, O'Brien S, Jabbour E, Garcia-Manero G, Quintas-Cardama A, Shan J, et al. Improved survival in chronic myeloid leukemia since the introduction of imatinib therapy: a single-institution historical experience. Blood. 2012;119(9):1981-7. doi:10.1182/blood-2011-08-358135.
  4. Druker BJ, Guilhot F, O'Brien SG, Gathmann I, Kantarjian H, Gattermann N, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med. 2006;355(23):2408-17. doi:10.1056/NEJMoa062867.
  5. Baccarani M, Deininger MW, Rosti G, Hochhaus A, Soverini S, Apperley JF, et al. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood. 2013;122(6):872-84. doi:10.1182/blood-2013-05-501569.
  6. Hasford J, Pfirrmann M, Hehlmann R, Allan NC, Baccarani M, Kluin-Nelemans JC, et al. A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. J Natl Cancer Inst. 1998;90(11):850-8. doi:10.1093/jnci/90.11.850.
  7. Branford S, Rudzki Z, Hochhaus A, Hensley ML, et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med. 2003;349(15):1423-32. doi:10.1056/NEJMoa030513.
  8. Van Etten RA. c-Abl regulation: a tail of two lipids. Curr Biol. 2003;13(15):R608-10. doi:10.1016/S0960-9822(03)00528-1.
  9. Smith AG, Painter D, Howell DA, Evans P, Smith G, Patmore R, et al. Determinants of survival in patients with chronic myeloid leukaemia treated in the new era of oral therapy: findings from a UK population-based patient cohort. BMJ Open. 2014;4(1):e004266. doi:10.1136/bmjopen-2013-004266.
  10. Rohrbacher M, Berger U, Hochhaus A, Metzgeroth G, Adam K, Lahaye T, et al. Clinical trials underestimate the age of chronic myeloid leukemia (CML) patients. Incidence and median age of Ph/BCR-ABL-positive CML and other chronic myeloproliferative disorders in a representative area in Germany. Leukemia. 2009;23(3):602-4. doi:10.1038/leu.2008.245.
  11. Rohrbacher M, Hasford J. Epidemiology of chronic myeloid leukaemia (CML). Best Pract Res Clin Haematol. 2009;22(3):295-302. doi:10.1016/j.beha.2009.07.007.
  12. Berger U, Maywald O, Pfirrmann M, Lahaye T, Hochhaus A, Reiter A, et al. Gender aspects in chronic myeloid leukemia: long-term results from randomized studies. Leukemia. 2005;19(6):984-9. doi:10.1038/sj.leu.2403756.
  13. Savage DG, Szydlo RM, Goldman JM. Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16-year period. Br J Haematol. 1997;96(1):111-6. doi:10.1046/j.1365-2141.1997.d01-1982.x.
  14. Saussele S, Krauss MP, Hehlmann R, Lauseker M, Proetel U, Kalmanti L, et al. Impact of comorbidities on overall survival in patients with chronic myeloid leukemia: results of the randomized CML Study IV. Blood. 2015;126(1):42-9. doi:10.1182/blood-2015-01-617993.
  15. Hughes T, Deininger M, Hochhaus A, Branford S, Radich J, Kaeda J, et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood. 2006;108(1):28-37. doi:10.1182/blood-2006-01-0092.
  16. Vigneri P, Stagno F, Stella S, Cupri A, Massimino M, Antolino A, et al. BCR-ABL(IS) expression at diagnosis and after 3 or 6 months of treatment predicts CML response to imatinib therapy. Blood. 2010;116:3426. doi:10.1182/blood.V116.21.3426.3426.
  17. Jabbour E, Kantarjian H, O'Brien S, Shan J, Quintas-Cardama A, Faderl S, et al. The achievement of an early complete cytogenetic response is a major determinant for outcome in patients with early chronic phase chronic myeloid leukemia treated with tyrosine kinase inhibitors. Blood. 2011;118(17):4541-6. doi:10.1182/blood-2011-04-348110.
  18. El-Metnawy WH, Mattar MM, El-Nahass YH, Samra MA, Abdelhamid HM, Abdlfattah RM, et al. Predictive value of pretreatment BCR-ABL(IS) transcript level on response to imatinib therapy in Egyptian patients with chronic phase chronic myeloid leukemia (CPCML). Int J Biomed Sci. 2013;9(1):48-53. PMID:23675289.