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Journals / Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi / 2026 / Cilt: 14 Sayı: 1

Synthesis and Characterization of Novel Heteroarylacrylonitrile Derivatives Containing Pyrazole Scaffold

Abdullah Biçer(BILECIK SEYH EDEBALI UNIVERSITY)0000-0003-4648-1834
Pages
326–332
Publication Date
2024-03-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The structures of the synthesized compounds were elucidated by FTIR, 1H-NMR and 13C-NMR spectroscopic techniques.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:2,3-disubstituted acrylonitriles derivatives are among the most important molecules in medicinal chemistry due to their bioactivity and their role as starting compounds for many bioactive molecules.
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Key Findings & Data:In this context, acrylonitrile compounds with aryl and heteroaryl structures at positions 2 and 3 (respectively )were synthesized from the reactions of pyrazole aldehyde derivative (4) with various acetonitrile compounds.
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Conclusion & Impact:The structures of the synthesized compounds were elucidated by FTIR, 1H-NMR and 13C-NMR spectroscopic techniques.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Arylacrylonitrile · Knoevenagel · Pyrazole

Abstract

2,3-disubstituted acrylonitriles derivatives are among the most important molecules in medicinal chemistry due to their bioactivity and their role as starting compounds for many bioactive molecules. Many heterocyclic structures have been investigated as AChE enzyme inhibitors. Nowadays, E/Z acrylonitrile derivatives are being studied as new AChE inhibitors. This study aimed to synthesis new heteroaryl-acrylonitrile compounds using Knoevenagel condensation. In this context, acrylonitrile compounds with aryl and heteroaryl structures at positions 2 and 3 (respectively )were synthesized from the reactions of pyrazole aldehyde derivative (4) with various acetonitrile compounds. Synthesized novel heteroarylacrylonitrile derivatives (5a-d) containing pyrazole ring are potential AChE inhibitors. The structures of the synthesized compounds were elucidated by FTIR, 1H-NMR and 13C-NMR spectroscopic techniques.

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Cite This Article

Biçer, A. (2024). Synthesis and Characterization of Novel Heteroarylacrylonitrile Derivatives Containing Pyrazole Scaffold. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Cilt: 14 Sayı: 1, 326–332. https://doi.org/10.21597/jist.1339475

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