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Journals / Bor Dergisi / 2026 / Cilt: 10 Sayı: 3

Antimicrobial potential of boron-containing compounds: Antibacterial, antifungal, and antimycobacterial activities

Bor içeren bileşiklerin antimikrobiyal potansiyeli: Antibakteriyel, antifungal ve antimikobakteriyel aktiviteler

Pınar Güner(BALIKESİR ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ)0000-0001-6922-7009
Tülin Aşkun(BALIKESİR ÜNİVERSİTESİ)0000-0002-2700-1965
Aylin Er(BALIKESİR ÜNİVERSİTESİ)0000-0002-8108-8950
Pages
111–120
Publication Date
2025-09-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, further in vivo studies, toxicological assessments, and mechanistic investigations are necessary to support their clinical application.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The global rise in multidrug-resistant (MDR) pathogens necessitates the discovery of new antimicrobial agents.
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Key Findings & Data:The current study aimed to investigate the antibacterial, antifungal, and antimycobacterial activities of four different BCCs (Zinc borate, boric acid, borax, and Etidot-67) by determining their minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentrations (MBC/MFC).
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Conclusion & Impact:However, further in vivo studies, toxicological assessments, and mechanistic investigations are necessary to support their clinical application.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:antibakteriyal aktivite · antifungal aktivite · antimikobakteriyal aktivite

Abstract

The global rise in multidrug-resistant (MDR) pathogens necessitates the discovery of new antimicrobial agents. Boron-containing compounds (BCCs) are increasingly studied for their broad-spectrum biological activities. The current study aimed to investigate the antibacterial, antifungal, and antimycobacterial activities of four different BCCs (Zinc borate, boric acid, borax, and Etidot-67) by determining their minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentrations (MBC/MFC). For the first time, the antimycobacterial activity of BCCs was evaluated against both reference and clinical strains. All tested compounds exhibited notable antimicrobial activity. Among them, boric acid and zinc borate showed strong antibacterial effects, particularly against Staphylococcus aureus and Salmonella typhimurium at 64 μg/mL. Borax displayed the most potent antimycobacterial activity, with a MIC of 64 μg/mL against Mycobacterium tuberculosis H37Ra (MT-H37Ra). Antifungal tests revealed boric acid to be highly effective against Candida albicans and Saccharomyces cerevisiae, with MIC values as low as 8-16 μg/ mL. These findings suggest that BCCs, especially borax and boric acid, may serve as viable candidates for the development of alternative antimicrobial therapies. However, further in vivo studies, toxicological assessments, and mechanistic investigations are necessary to support their clinical application.

Özet

Çoklu ilaca dirençli (MDR) patojenlerdeki küresel artış, yeni antimikrobiyal ajanların keşfini zorunlu kılmaktadır. Bor içeren bileşikler (BİB'ler), geniş spektrumlu biyolojik aktiviteleri nedeniyle giderek daha fazla araştırılmaktadır. Bu çalışma, dört farklı BİB'in (Çinko borat, borik asit, boraks ve Etidot-67) minimum inhibitör konsantrasyonlarını (MİK) ve minimum bakterisidal/fungisidal konsantrasyonlarını (MBK/MFK) belirleyerek antibakteriyel, antifungal ve antimikobakteriyel aktivitelerini araştırmayı amaçlamaktadır. BİB'lerin antimikobakteriyel aktivitesi ilk kez hem referans hem de klinik suşlara karşı değerlendirilmiştir. Test edilen tüm bileşikler anlamlı antimikrobiyal aktivite göstermiştir. Bunlar arasında borik asit ve çinko borat, özellikle 64 μg/mL'de Staphylococcus aureus ve Salmonella typhimurium'a karşı güçlü antibakteriyel etkiler göstermiştir. Boraks, Mycobacterium tuberculosis H37Ra'ya (MT-H37Ra) karşı 64 μg/mL'lik bir MİK ile en güçlü antimikobakteriyel aktiviteyi göstermiştir. Antifungal testler, borik asidin Candida albicans ve Saccharomyces cerevisiae'ye karşı oldukça etkili olduğunu ve MİK değerlerinin 8-16 μg/mL kadar düşük olduğunu göstermiştir. Bu bulgular, özellikle boraks ve borik asit olmak üzere BİB'lerin alternatif antimikrobiyal tedavilerin geliştirilmesi için uygun adaylar olabileceğini düşündürmektedir. Ancak, klinik uygulamalarını desteklemek için daha fazla in vivo çalışma, toksikolojik değerlendirme ve mekanik incelemeye ihtiyaç vardır.

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Cite This Article

Güner, P., Aşkun, T., Er, A. (2025). Antimicrobial potential of boron-containing compounds: Antibacterial, antifungal, and antimycobacterial activities. Bor Dergisi, Cilt: 10 Sayı: 3, 111–120. https://doi.org/10.30728/boron.1693877

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