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Journals / Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi / 2026 / Cilt: 11 Sayı: 1

Therapeutic Effect of Astaxanthin on 5-Fluorouracil-Induced Ovarian Damage in Rats

Astaksantin'in Sıçanlarda 5-Florourasil ile İndüklenen Over Hasarı Üzerindeki Terapötik Etkisi

Elif Ayazoglu Demir(KARADENİZ TEKNİK ÜNİVERSİTESİ)0000-0001-7188-2176
Ahmet Mentese(KARADENİZ TEKNİK ÜNİVERSİTESİ)0000-0003-2036-5317
Ayten Livaoglu(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, TRABZON KANUNİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ)0000-0001-9168-6113
Nihal Türkmen(RECEP TAYYİP ERDOĞAN ÜNİVERSİTESİ)0000-0002-8913-8692
Selim Demir(Karadeniz Teknik Üniversitesi Sağlık Bilimleri Fakültesi Beslenme ve Diyetetik Bölümü)0000-0002-1863-6280
Yüksel Aliyazıcıoğlu(KARADENİZ TEKNİK ÜNİVERSİTESİ)0000-0001-9474-4307
Pages
47–55
Publication Date
2024-05-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings reveal that ASX may exert an ovoprotective effect by reducing pro-inflammatory mediators and enhancing antioxidant status in ovarian tissue.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Although astaxanthin (ASX) is one of the most studied antioxidant molecules, its curative effect against ovarian damage caused by 5-fluorouracil (5-FU) has not been demonstrated to date.
📊
Key Findings & Data:It was therefore aimed to investigate whether ASX is therapeutic against 5-FU-induced ovotoxicity in this study.
💡
Conclusion & Impact:These findings reveal that ASX may exert an ovoprotective effect by reducing pro-inflammatory mediators and enhancing antioxidant status in ovarian tissue.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:5-florourasil · Astaksantin · İnflamasyon

Abstract

Although astaxanthin (ASX) is one of the most studied antioxidant molecules, its curative effect against ovarian damage caused by 5-fluorouracil (5-FU) has not been demonstrated to date. It was therefore aimed to investigate whether ASX is therapeutic against 5-FU-induced ovotoxicity in this study. Rats were first exposed to 5-FU (100 mg/kg) and then treated ASX (250 μg/kg) for three days. Oxidative stress (OS), inflammation and apoptosis markers were determined using spectrophotometric methods. Ovarian tissues were also evaluated histologically. The levels of OS, inflammation and apoptosis biomarkers increased by 5-FU administration (p<0.05). Treatment with ASX significantly alleviated these markers (p<0.05). These findings reveal that ASX may exert an ovoprotective effect by reducing pro-inflammatory mediators and enhancing antioxidant status in ovarian tissue.

Özet

Astaksantin (ASX) üzerinde en çok çalışılan antioksidan moleküllerden biri olmasına rağmen, 5-florourasil (5-FU)'in neden olduğu yumurtalık hasarına karşı iyileştirici etkisi bugüne kadar gösterilmemiştir. Bu nedenle bu çalışmada ASX'in 5-FU ile indüklenen ovotoksisiteye karşı terapötik olup olmadığının araştırılması amaçlandı. Sıçanlar önce 5-FU'ya (100 mg/kg) maruz bırakıldı ve ardından üç gün boyunca ASX (250 μg/kg) tedavisi gördü. Oksidatif stres (OS), inflamasyon ve apoptoz belirteçleri spektrofotometrik yöntemlerle belirlendi. Ayrıca yumurtalık dokuları histolojik olarak da değerlendirildi. OS, inflamasyon ve apoptoz biyobelirteçlerinin seviyeleri 5-FU uygulamasıyla arttı (p<0.05). ASX ile tedavi bu belirteçleri önemli ölçüde iyileştirdi (p<0.05). Bu bulgular, ASX'in yumurtalık dokusunda pro-inflamatuar mediatörleri azaltarak ve antioksidan durumu güçlendirerek yumurtalık koruyucu bir etki gösterebileceğini ortaya koymaktadır.

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Cite This Article

Demir, E. A., Mentese, A., Livaoglu, A., Türkmen, N., Demir, S., Aliyazıcıoğlu, Y. (2024). Therapeutic Effect of Astaxanthin on 5-Fluorouracil-Induced Ovarian Damage in Rats. Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi, Cilt: 11 Sayı: 1, 47–55. https://doi.org/10.35193/bseufbd.1222648

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