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Journals / Eurasian Journal of Medicine and Oncology / 2019 / Cilt: 3 - Sayı: 4

Significance of DEPDC5 and MICA Variants in Hepatocellular Carcinoma risk related Hepatitis C Virus patients in Egypt

Mai M. EL DALY
Hany M. IBRAHIM
Eman LABİB
Heba S. GHANEM
Ibrahim A. EL ELAİMY
Mohamed ABDEL HAMİD
Pages
274–280
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: DEPDC5 (rs1012068) and MICA (rs2596542) could be a valuable indicator in diagnosing the progression of liver disease to HCC risk related Hepatitis C Virus patients in Egypt.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Hepatitis C virus (HCV) infection is one of the major causes of hepatocellular carcinoma (HCC) in Egypt.
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Key Findings & Data:Recently, genetic polymorphisms of DEPDC5 and MICA have been reported to correlate with the progression of HCC in hepatitis C patients.
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Conclusion & Impact:Conclusion: DEPDC5 (rs1012068) and MICA (rs2596542) could be a valuable indicator in diagnosing the progression of liver disease to HCC risk related Hepatitis C Virus patients in Egypt.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objectives: Hepatitis C virus (HCV) infection is one of the major causes of hepatocellular carcinoma (HCC) in Egypt. Recently, genetic polymorphisms of DEPDC5 and MICA have been reported to correlate with the progression of HCC in hepatitis C patients. The aim of this study was to determine the relationship between DEPDC5 (rs1012068) T/G, MICA (rs2596542) C/T and the risk of HCC development in patients with HCV infection. Methods: One hundred HCV infected patients suffering from HCC and one hundred healthy controls were enrolled in the current study. Single nucleotide polymorphisms (SNPs) have been studied for DEPDC5 and MICA using real-time PCR. Results: Out of the two genes polymorphisms analyzed, the DEPDC5 and MICA variants were significantly related to the development of HCC (p<0.0001). Only the DEPDC5 variants showed a high (p<0.0001) significant difference in patients with cirrhosis. Moreover, the DEPDC5 variants were significantly correlated with low platelets count (p<0.045). Conclusion: DEPDC5 (rs1012068) and MICA (rs2596542) could be a valuable indicator in diagnosing the progression of liver disease to HCC risk related Hepatitis C Virus patients in Egypt.

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Cite This Article

DALY, M. M. E., IBRAHIM, H. M., LABİB, E., GHANEM, H. S., ELAİMY, I. A. E., HAMİD, M. A. (2019). Significance of DEPDC5 and MICA Variants in Hepatocellular Carcinoma risk related Hepatitis C Virus patients in Egypt. Eurasian Journal of Medicine and Oncology, Cilt: 3 - Sayı: 4, 274–280. https://ajindex.com/articles/126120

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