Journals / Eurasian Journal of Medicine and Oncology / 2020 / Cilt: 4 - Sayı: 3

Bioinformatics Approach for COVID-19 (Coronavirus) Disease Prevention Treatment and Drug Validation

Pages
234–238
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It helps us in predicting the intermolecular frame work formed between a protein or a small molecule.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: To find out the effect of Hydroxychloroquine on COVID special protease.
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Key Findings & Data:Results: Hydrochloroquine Bind and release over Protease 6y84 and 7buy and controlled their action in body.
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Conclusion & Impact:It helps us in predicting the intermolecular frame work formed between a protein or a small molecule.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objectives: To find out the effect of Hydroxychloroquine on COVID special protease. Methods: PyMOL software used to find out all possible rotameters of residue and their probability. AutoDock software used to calculates and predict the interaction of molecules. Results: Hydrochloroquine Bind and release over Protease 6y84 and 7buy and controlled their action in body. Conclusion: Drug designing and docking is helpful for specific disease. It helps us in predicting the intermolecular frame work formed between a protein or a small molecule.

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Cite This Article

MİSHRA, S., JAİN, P. A., Ahmad, S., MİSHRA, S. (2020). Bioinformatics Approach for COVID-19 (Coronavirus) Disease Prevention Treatment and Drug Validation. Eurasian Journal of Medicine and Oncology, Cilt: 4 - Sayı: 3, 234–238. https://ajindex.com/articles/125544

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References (14)

  1. Ahmad S, Hafeez A, Siddqui SA, Ahmad M, Mishra S. A Review of COVID-19 (Coronavirus Disease-2019) Diagnosis, Treatments and Prevention. EJMO 2020;4:116–25
  2. Singhal T. A Review of Coronavirus Disease-2019 (COVID-19). Indian J Pediatr 2020;87:281–6
  3. Cascella M, Rajnik M, Cuomo A, et al. Features, Evaluation and Treatment Coronavirus (COVID-19) [Updated 2020 Apr 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/ books/NBK554776/ 4. WorldMeters, https://www.worldometers.info/coronavirus/ (Accessed May 22, 2020)
  4. Johns Hopkins University, COVID-19 Map FAQ, https://coronavirus.jhu.edu/map-faq (Accessed May 23, 2020)
  5. WHO, Coronavirus disease 2019 (COVID-19) situation reports. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports (Accessed Feb 17, 2020)
  6. Universal Community Health Center, Coronavirus COVID-19 Global Cases. https://www.uchcla.org/post/coronavirus-covid-19-global-cases (Accessed May 23, 2020)
  7. DocPlayer.net. Pymol Tutorial. Go to This is the Protein Data Bank (PDB) - a database for protein structures. http://docplayer.net/34862614-Pymol-tutorial-go-to-this-is-the-proteindata-bank-pdb-a-database-for-protein-structures.html (Accessed May 23, 2020)
  8. Epidemiology Working Group for NCIP Epidemic Response, Chinese Center for Disease Control and Prevention. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, vol. 41, no. 2, 2020, pp. 145-151
  9. Dong E, Du H, Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis 2020;20:533– 4
  10. Pirhadi S, Sunseri J, Koes DR. Open source molecular modeling. J Mol Graph Model 2016;69:127–43
  11. O'Boyle, N.M., Banck, M., James, C.A. et al. Open Babel: An open chemical toolbox. J Cheminform 3, 33 (2011). https:// doi.org/10.1186/1758-2946-3-33 13. Meng XY, Zhang HX, Mezei M, Cui M. Molecular docking: a powerful approach for structure-based drug discovery. Curr Comput Aided Drug Des 2011;7:146–57
  12. Forli S, Huey R, Pique ME, Sanner MF, Goodsell DS, Olson AJ. Computational protein-ligand docking and virtual drug screening with the AutoDock suite. Nat Protoc 2016;11:905– 19
  13. Meng XY, Zhang HX, Mezei M, Cui M. Molecular docking: a powerful approach for structure-based drug discovery. Curr Comput Aided Drug Des 2011;7:146–57
  14. Taoufik, A, Lamchouri, F., Senhaji, S., Toufik, H., (2019). Molecular docking, ADME/Tox prediction, an