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Journals / Journal of Istanbul Veterinary Sciences / 2026 / Cilt: 10 Sayı: 1

Determination of Serum Concentrations of Vitamins A, D, E, and K in Cattle Naturally Infected with Theileria annulata

Vural Denizhan(VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ)0000-0002-0531-9550
Süleyman Kozat(VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ)0000-0000-5089-2623
Pages
49–53
Publication Date
2026-04-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Monitoring and supplementation of these vitamins, when necessary, may help support recovery in infected animals.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Abstract This study aimed to evaluate the serum concentrations of the fat-soluble vitamins A, D, E, and K in cattle naturally infected with Theileria annulata.
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Key Findings & Data:A total of 20 cattle of different ages, breeds, and sexes were included in the study; ten were infected animals and ten served as healthy controls.
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Conclusion & Impact:Monitoring and supplementation of these vitamins, when necessary, may help support recovery in infected animals.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:cattle · vitamin A · infected

Abstract

Abstract This study aimed to evaluate the serum concentrations of the fat-soluble vitamins A, D, E, and K in cattle naturally infected with Theileria annulata. A total of 20 cattle of different ages, breeds, and sexes were included in the study; ten were infected animals and ten served as healthy controls. Blood samples were collected for microscopic diagnosis and serum separation. Serum levels of retinol (vitamin A), cholecalciferol (vitamin D₃), α-tocopherol (vitamin E), and phylloquinone (vitamin K₁) were measured. The results revealed significant decreases in vitamins A, D, and E in infected cattle compared to the control group (P < 0.05), while vitamin K₁ levels were not significantly affected. These findings suggest that T. annulata infection may lead to deficiencies in specific fat-soluble vitamins, potentially impairing immune function. Monitoring and supplementation of these vitamins, when necessary, may help support recovery in infected animals.

Özet

Abstract This study aimed to evaluate the serum concentrations of the fat-soluble vitamins A, D, E, and K in cattle naturally infected with Theileria annulata. A total of 20 cattle of different ages, breeds, and sexes were included in the study; ten were infected animals and ten served as healthy controls. Blood samples were collected for microscopic diagnosis and serum separation. Serum levels of retinol (vitamin A), cholecalciferol (vitamin D₃), α-tocopherol (vitamin E), and phylloquinone (vitamin K₁) were measured. The results revealed significant decreases in vitamins A, D, and E in infected cattle compared to the control group (P < 0.05), while vitamin K₁ levels were not significantly affected. These findings suggest that T. annulata infection may lead to deficiencies in specific fat-soluble vitamins, potentially impairing immune function. Monitoring and supplementation of these vitamins, when necessary, may help support recovery in infected animals.

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Cite This Article

Denizhan, V., Kozat, S. (2026). Determination of Serum Concentrations of Vitamins A, D, E, and K in Cattle Naturally Infected with Theileria annulata. Journal of Istanbul Veterinary Sciences, Cilt: 10 Sayı: 1, 49–53. https://doi.org/10.30704/http-www-jivs-net.1818844

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References (18)

  1. Amimo, J. O., Michael, H., Chepngeno, J., Raev, S. A., Saif, L. J., & Vlasova, A. N. (2022). Immune impairment associated with vitamin A deficiency: insights from clinical studies and animal model research. Nutrients, 14 (23), 5038.
  2. Dede, S., Değer, Y., & Ergün, Y. (2002). Lipid peroxidation and antioxidant status in cattle with babesiosis. Acta Veterinaria Hungarica, 50(3), 295–300.
  3. Denizhan, V., Kozat, S., & Ozkan, C. (2017). Evaluation of cobalt, vitamin B12 and homocysteine levels in cattle infected with Theileria annulata. Journal of Livestock Science, 8, 72–76.
  4. Dobbelaere, D. A. E., & Heussler, V. T. (1999). Transformation of leukocytes by Theileria parva and Theileria annulata. Annual Review of Microbiology, 53, 1–42.
  5. El-Deeb, W. M., & Younis, E. E. (2019). Clinical and biochemical studies on Theileria annulata in cattle: Oxidative stress and immunological aspects. Tropical Animal Health and Production, 51(8), 2405–2414.
  6. Gröber, U., Reichrath, J., & Holick, M. F. (2015). Live longer with vitamin D. Nutrients, 7(3), 1871–1880.
  7. Hewison, M. (2012). Vitamin D and the immune system: New perspectives on an old theme. Endocrinology and Metabolism Clinics of North America, 41(3), 595–615.
  8. Leung, H. W., Vang, M. J., & Mavis, R. D. (1981). The cooperative interaction between vitamin E and vitamin C in the antioxidant defense system. Biochimica et Biophysica Acta, 664(2), 266–272.
  9. Mans, B. J., Pienaar, R., & Latif, A. A. (2015). A review of Theileria diagnostics and epidemiology. Veterinary Parasitology, 211(3–4), 209–220.
  10. Nazifi, S., Razavi, S. M., Hasanshahi, F., & Esmailnezhad, Z. (2009). Effect of the severity of Theileria annulata infection on some haematological parameters and antioxidant enzymes in naturally infected cattle. Bulgarian Journal of Veterinary Medicine, 12(1), 63–71.
  11. Nelson, C. D., Reinhardt, T. A., Lippolis, J. D., Sacco, R. E., & Nonnecke, B. J. (2012). Vitamin D signaling in the bovine immune system: A model for understanding human vitamin D requirements. Nutrients, 4(3), 181–196.
  12. Niki, E. (2021). Lipid oxidation that is, and is not, inhibited by vitamin E: Consideration about physiological functions of vitamin E. Free Radical Biology and Medicine, 176, 1–15. https://doi.org/10.1016/j.freeradbiomed.2021.09.001
  13. Omer, O.H., El-Malik, K.H., Mahmoud, O.M., Haroun, E. M., Hawas, A., Sweeney, D., & Magzoub, M. (2002). Haematological profiles in pure bred cattle naturally infected with Theileria annulata in Saudi Arabia. Veterinary Parasitology, 107(1–2), 161–168.
  14. Radostits, O. M., Gay, C. C., Hinchcliff, K. W., & Constable, P. D. (2010). Veterinary medicine: A textbook of the diseases of cattle, horses, sheep, pigs, and goats (10th ed.). Saunders Elsevier.
  15. Rezaei, S.A., & Dalir-Naghadeh, B. (2006). Evaluation of antioxidant status and oxidative stress in cattle naturally infected with Theileria annulata. Veterinary Parasitology, 142(1–2), 179–186.
  16. Selim, A., Weir, W., & Khater, H. (2022). Prevalence and risk factors associated with tropical theileriosis in Egyptian dairy cattle. Veterinary World, 15(4), 919–924.
  17. Su, Q., Rowley, K.G., & Balazs, N.D. (2002). Carotenoids: Separation methods applicable to biological samples. Journal of Chromatography B, 781, 393–418.
  18. Sultana, H., Komai, M., & Shirakawa, H. (2021). The role of vitamin K in cholestatic liver disease. Nutrients, 13 (8), 2515.