Journals / Turkish Journal of Veterinary and Animal Sciences / 2009 / Cilt: 33 - Sayı: 2

Concentration of Products of Nitric Oxide Oxidation and Some Vitamins in Sheep with Naturally Acquired Babesiosis

Pages
131–135
Publication Date
2009-02-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

On the other hand, a significant decrease was observed in a -tocopherol levels in sheep with babesiosis because of damage and pathophysiological changes to erythrocytes.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The aim of the present study was to determine serum concentrations of the products of nitric oxide oxidation (nitrate and nitrite) and some vitamins (retinol acetate, a- and d-tocopherol, and vitamin D3) in sheep naturally infected with Babesia ovis.
📊
Key Findings & Data:The investigation included 30 infected and 10 control sheep.
💡
Conclusion & Impact:On the other hand, a significant decrease was observed in a -tocopherol levels in sheep with babesiosis because of damage and pathophysiological changes to erythrocytes.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Babesiosis · nitric oxide · sheep

Abstract

The aim of the present study was to determine serum concentrations of the products of nitric oxide oxidation (nitrate and nitrite) and some vitamins (retinol acetate, a- and d-tocopherol, and vitamin D3) in sheep naturally infected with Babesia ovis. The investigation included 30 infected and 10 control sheep. Serum a -tocopherol levels were significantly lower (P < 0.05), and nitrate and nitrite concentrations were significantly higher (P < 0.05) in infected animals than in controls. It is thought that the elevated nitrate and nitrite levels of the sheep infected with babesiosis were due to the result of damage caused by Babesia. On the other hand, a significant decrease was observed in a -tocopherol levels in sheep with babesiosis because of damage and pathophysiological changes to erythrocytes.

Özet

The aim of the present study was to determine serum concentrations of the products of nitric oxide oxidation (nitrate and nitrite) and some vitamins (retinol acetate, a- and d-tocopherol, and vitamin D3) in sheep naturally infected with Babesia ovis. The investigation included 30 infected and 10 control sheep. Serum a -tocopherol levels were significantly lower (P < 0.05), and nitrate and nitrite concentrations were significantly higher (P < 0.05) in infected animals than in controls. It is thought that the elevated nitrate and nitrite levels of the sheep infected with babesiosis were due to the result of damage caused by Babesia. On the other hand, a significant decrease was observed in a -tocopherol levels in sheep with babesiosis because of damage and pathophysiological changes to erythrocytes.

🔖

Cite This Article

MERT, H., YÖRÜK, İ., DEĞER, Y., MERT, N., DEDE, S., YUR, F. (2009). Concentration of Products of Nitric Oxide Oxidation and Some Vitamins in Sheep with Naturally Acquired Babesiosis. Turkish Journal of Veterinary and Animal Sciences, Cilt: 33 - Sayı: 2, 131–135. https://ajindex.com/articles/122073

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (11)

  1. Stahr, H.M.: Analytical Toxicology Methods Manual. Iowa State University Press.
  2. Ames, Iowa, USA, 1977; 68-71.
  3. Liew, F.Y., Millott, S., Parkinson, C., Palmer, R.M., Moncada, S.: Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine. J. Immunol., 1990; 144: 4794- 4797. Shoda, L.K., Palmer, G.H., Florin-Christensen, J., Florin- Christensen, M., Godson, D.L., Brown, W.C.: Babesia bovis- stimulated macrophages express interleukin-1beta, interleukin- 12, tumor necrosis factor alpha, and nitric oxide and inhibit parasite replication in vitro. Infect. Immun., 2000; 68: 5139– 5145. Hanafusa, Y., Cho, K.O., Kanemaru, T., Wada, R., Sugimoto, C., Onuma, M.: Pathogenesis of Babesia caballi infection in experimental horses. J. Vet. Med. Sci., 1998; 60: 1127–1132.
  4. Jacobs, P., Radzioch, D., Stevenson, M.M.: A Th1-associated increase in tumor necrosis factor alpha expression in the spleen correlates with resistance to blood-stage malaria in mice. Infect. Immun., 1996; 64: 535-541.
  5. Kumaratilake, L.M., Ferrante, A., Rzepczyk, C.M.: Tumor necrosis factor enhances neutrophil-mediated killing of Plasmodium falciparum. Infect. Immun., 1990; 58: 788-793. Franková, D., Zidek, Z.: IFN-gamma-induced TNF-alpha is a prerequisite for in vitro production of nitric oxide generated in murine peritoneal macrophages by IFN-gamma. Eur. J. Immunol., 1998; 28: 838-843.
  6. Brown, W.C., Palmer, G.H.: Designing blood-stage vaccines against Babesia bovis and B. bigemina. Parasitol. Today, 1999; 15: 275-281.
  7. Gale, K.R., Waltisbuhl, D.J., Bowden, J.M., Jorgensen, W.K., Matheson, J., East, I.J., Zakrzewski, H., Leatch, G.: Amelioration of virulent Babesia bovis infection in calves by administration of the nitric oxide synthase inhibitor aminoguanidine. Parasite Immunol., 1998; 20: 441-445.
  8. Brown, W.C., Suarez, C.E., Shoda, L.K., Estes, D.M.: Modulation of host immune responses by protozoal DNA. Vet. Immunol. Immunopathol., 1999; 72: 87-94.
  9. Johnson, W.C., Cluff, C.W., Goff, W.L., Wyatt, C.R.: Reactive oxygen and nitrogen intermediates and products from polyamine degradation are Babesiacidal in vitro. Ann. N.Y. Acad Sci., 1996; 791: 136-147.
  10. Mishra, N.C., Kabilan, L., Sharma, A.: Oxidative stress and malaria-infected erythrocytes. Indian J. Malariol., 1994; 31: 77- 87. Jacobson, L.S., Lobetti, R.G.: Rhabdomyolysis as a complication of canine babesiosis. J. Small Anim. Pract., 1996; 37: 286-291.
  11. Wright, I.G., Goodger, B.V., Buffington, G.D., Clark, I.A., Parrodi, F.,