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Journals / Turkish Journal of Veterinary and Animal Sciences / 2011 / Cilt: 35 - Sayı: 3

The increase of CD4+CD25+ T cells in the peripheral blood of pigs persistently infected with porcine reproductive and respiratory syndrome virus

Jingwen ZENG
Danting HE
Xin GUO
Xinna GE
Hanchun YANG
Pages
177–182
Publication Date
2011-03-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This study contributes to a better understanding of the immunological basis of PRRSV persistence.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Regulatory T lymphocytes (T-regs) may be involved in suppressing the host's immunity, which is important for viral clearance, and may therefore contribute to persistent viral infection.
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Key Findings & Data:This study, which used flow cytometry and real-time PCR, determined that the frequencies of CD4+CD25+ T-cells and porcine Forkhead/winged helix transcription factor (FoxP3) mRNA levels in peripheral blood significantly increased during PRRSV persistence, indicating that CD4+CD25+ T-regs might play an important role in PRRSV persistent infection.
💡
Conclusion & Impact:This study contributes to a better understanding of the immunological basis of PRRSV persistence.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Key words: Porcine reproductive and respiratory syndrome virus · PRRSV · persistent infection

Abstract

Regulatory T lymphocytes (T-regs) may be involved in suppressing the host's immunity, which is important for viral clearance, and may therefore contribute to persistent viral infection. However, nothing is known regarding the situation of porcine T-regs during persistent infection with porcine reproductive and respiratory syndrome virus (PRRSV). This study, which used flow cytometry and real-time PCR, determined that the frequencies of CD4+CD25+ T-cells and porcine Forkhead/winged helix transcription factor (FoxP3) mRNA levels in peripheral blood significantly increased during PRRSV persistence, indicating that CD4+CD25+ T-regs might play an important role in PRRSV persistent infection. This study contributes to a better understanding of the immunological basis of PRRSV persistence.

Özet

Regulatory T lymphocytes (T-regs) may be involved in suppressing the host's immunity, which is important for viral clearance, and may therefore contribute to persistent viral infection. However, nothing is known regarding the situation of porcine T-regs during persistent infection with porcine reproductive and respiratory syndrome virus (PRRSV). This study, which used flow cytometry and real-time PCR, determined that the frequencies of CD4+CD25+ T-cells and porcine Forkhead/winged helix transcription factor (FoxP3) mRNA levels in peripheral blood significantly increased during PRRSV persistence, indicating that CD4+CD25+ T-regs might play an important role in PRRSV persistent infection. This study contributes to a better understanding of the immunological basis of PRRSV persistence.

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Cite This Article

ZENG, J., HE, D., GUO, X., GE, X., YANG, H. (2011). The increase of CD4+CD25+ T cells in the peripheral blood of pigs persistently infected with porcine reproductive and respiratory syndrome virus. Turkish Journal of Veterinary and Animal Sciences, Cilt: 35 - Sayı: 3, 177–182. https://ajindex.com/articles/122058

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References (12)

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