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Journals / Turkish Journal of Veterinary and Animal Sciences / 2014 / Cilt: 38 - Sayı: 6

Maternal embryokines that regulate development of the bovine preimplantation embryo

Peter James HANSEN
Anna Carolina DENICOL
Kyle Bradley DOBBS
Pages
589–598
Publication Date
2014-06-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Together, these molecules regulate key events required for development of the embryo to the blastocyst stage including proliferation (enhanced by IGF1), development of the inner cell mass (regulated by CSF2), control of differentiation (modified by DKK1), and inhibition of apoptosis and stress-mediated developmental arrest (IGF1 and CSF2).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Proper embryonic development depends upon regulatory signals from the reproductive tract called embryokines.
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Key Findings & Data:The focus is on 3 embryokines that have been shown to increase competence of embryos to survive after transfer to recipients: CSF2, IGF1, and DKK1.
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Conclusion & Impact:Together, these molecules regulate key events required for development of the embryo to the blastocyst stage including proliferation (enhanced by IGF1), development of the inner cell mass (regulated by CSF2), control of differentiation (modified by DKK1), and inhibition of apoptosis and stress-mediated developmental arrest (IGF1 and CSF2).
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Embryo · embryokine · colony stimulating factor 2

Abstract

Proper embryonic development depends upon regulatory signals from the reproductive tract called embryokines. This review uses the cow as a model to understand the developmental processes controlled by embryokines. The focus is on 3 embryokines that have been shown to increase competence of embryos to survive after transfer to recipients: CSF2, IGF1, and DKK1. Together, these molecules regulate key events required for development of the embryo to the blastocyst stage including proliferation (enhanced by IGF1), development of the inner cell mass (regulated by CSF2), control of differentiation (modified by DKK1), and inhibition of apoptosis and stress-mediated developmental arrest (IGF1 and CSF2).

Özet

Proper embryonic development depends upon regulatory signals from the reproductive tract called embryokines. This review uses the cow as a model to understand the developmental processes controlled by embryokines. The focus is on 3 embryokines that have been shown to increase competence of embryos to survive after transfer to recipients: CSF2, IGF1, and DKK1. Together, these molecules regulate key events required for development of the embryo to the blastocyst stage including proliferation (enhanced by IGF1), development of the inner cell mass (regulated by CSF2), control of differentiation (modified by DKK1), and inhibition of apoptosis and stress-mediated developmental arrest (IGF1 and CSF2).

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Cite This Article

HANSEN, P. J., DENICOL, A. C., DOBBS, K. B. (2014). Maternal embryokines that regulate development of the bovine preimplantation embryo. Turkish Journal of Veterinary and Animal Sciences, Cilt: 38 - Sayı: 6, 589–598. https://ajindex.com/articles/121541

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References (9)

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