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Journals / Kırıkkale Üniversitesi Tıp Fakültesi Dergisi / 2026 / Cilt: 22 Sayı: 2

The Investigation of Protocadherin Gene Family Members PCDH8, PCDH10, and PCDH17 as Epigenetic Biomarkers in Blood Samples of Patients with Bladder Tumor

MESANE TÜMÖRLÜ HASTALARIN KANLARINDA EPİGENETİK BİYOBELİRTEÇLER OLARAK PROTOKADERİN GEN AİLESİ ÜYELERİ PCDH8, PCDH10 VE PCDH17’NİN ARAŞTIRILMASI

Zeynep Yeğin(SİNOP ÜNİVERSİTESİ)0000-0003-4637-0253
Filiz Özen(İSTANBUL MEDENİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-9187-5387
Haydar Koç(ÇANKIRI KARATEKİN ÜNİVERSİTESİ, FEN FAKÜLTESİ)0000-0002-8568-4717
Asıf Yıldırım(İSTANBUL MEDENİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-3386-971X
Recep Büyükalpelli(ONDOKUZ MAYIS ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-9029-9023
Pages
163–171
Publication Date
2020-08-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The potential association between methylation profiles of the investigated three genes and demographic and/or clinicopathologic data was a second target of the study.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of the study was to evaluate the potential tumor-specific effects of peripheral blood DNA methylation profiles of protocadherin 8 (PCDH8), protocadherin 10 (PCDH10), and protocadherin 17 (PCDH17) genes who belong to the protocadherin gene family, in patients with bladder tumors and healthy controls.
📊
Key Findings & Data:Objective: The aim of the study was to evaluate the potential tumor-specific effects of peripheral blood DNA methylation profiles of protocadherin 8 (PCDH8), protocadherin 10 (PCDH10), and protocadherin 17 (PCDH17) genes who belong to the protocadherin gene family, in patients with bladder tumors and healthy controls.
💡
Conclusion & Impact:The potential association between methylation profiles of the investigated three genes and demographic and/or clinicopathologic data was a second target of the study.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Mesane kanseri · DNA metilasyonu · periferik kan

Abstract

Objective: The aim of the study was to evaluate the potential tumor-specific effects of peripheral blood DNA methylation profiles of protocadherin 8 (PCDH8), protocadherin 10 (PCDH10), and protocadherin 17 (PCDH17) genes who belong to the protocadherin gene family, in patients with bladder tumors and healthy controls. The potential association between methylation profiles of the investigated three genes and demographic and/or clinicopathologic data was a second target of the study.

Özet

Amaç: Çalışmanın amacı mesane tümörlü hastalarda ve sağlıklı kontrollerde protokaderin gen ailesine ait olan protokaderin 8 (PCDH8), protokaderin 10 (PCDH10) ve protokaderin 17 (PCDH17) genlerinin periferal kan DNA metilasyon profillerini analiz ederek bu profillerin tümör-spesifik olası etkilerini değerlendirmektir. Araştırılan üç genin metilasyon profiliyle spesifik demografik ve/veya klinikopatolojik veriler arasındaki olası ilişkinin araştırılması da çalışmanın ikinci hedefidir.

🔖

Cite This Article

Yeğin, Z., Özen, F., Koç, H., Yıldırım, A., Büyükalpelli, R. (2020). The Investigation of Protocadherin Gene Family Members PCDH8, PCDH10, and PCDH17 as Epigenetic Biomarkers in Blood Samples of Patients with Bladder Tumor. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, Cilt: 22 Sayı: 2, 163–171. https://doi.org/10.24938/kutfd.676670

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