Journals / Kırıkkale Üniversitesi Tıp Fakültesi Dergisi / 2025 / Cilt: 27 Sayı: 3

The Effect of Polypharmacy on Chronic Obstructive Pulmonary Disease Symptoms: An Observational Study

ÇOKLU İLAÇ KULLANIMININ KRONİK OBSTRÜKTİF AKCİĞER HASTALIĞI SEMPTOMLARI ÜZERİNE ETKİSİ: GÖZLEMSEL BİR ARAŞTIRMA

Baki Derhem(KIRIKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-6989-9873
Mert Kızmaz(KIRIKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0003-0530-0811
Aleyna Kaynar(KIRIKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0007-0787-2847
Merve Su Polat(KIRIKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0004-1199-2874
Seher Sokuoğlu(KIRIKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0006-1976-9049
Derviş Emre Çopur(KIRIKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0006-0722-3081
Pages
324–329
Publication Date
2025-12-25
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: When prescribing medications by family physicians, especially in primary care, a holistic approach should be taken, taking into account all medications used by the patients, COPD symptoms should be reviewed; if polypharmacy proves to be inevitable, rational choices should be made and the medication burden should be reduced by prioritizing certain medications.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: To investigate the effect of polypharmacy on symptoms of chronic obstructive pulmonary disease (COPD).
📊
Key Findings & Data:Material and Methods: This descriptive cross-sectional study included 96 patients aged 50 years and older who were admitted to Kırıkkale Medical Faculty, Departments of Family Medicine and Pulmonology between February-April 2025.
💡
Conclusion & Impact:Conclusion: When prescribing medications by family physicians, especially in primary care, a holistic approach should be taken, taking into account all medications used by the patients, COPD symptoms should be reviewed; if polypharmacy proves to be inevitable, rational choices should be made and the medication burden should be reduced by prioritizing certain medications.
🔬Design:Survey & Empirical Study
📍Scope:2025 Verileri
⚙️Variables:Aile hekimliği · çoklu ilaç kullanımı · kronik obstrüktif akciğer hastalığı

Abstract

Objective: To investigate the effect of polypharmacy on symptoms of chronic obstructive pulmonary disease (COPD). Material and Methods: This descriptive cross-sectional study included 96 patients aged 50 years and older who were admitted to Kırıkkale Medical Faculty, Departments of Family Medicine and Pulmonology between February-April 2025. The modified Medical Research Council (mMRC) and the COPD Assessment Test (CAT) questionnaires assessing COPD symptom severity and a form including sociodemographic data were completed through face-to-face interviews. During the interview, patients were asked to indicate all medications prescribed to them by a physician and these were verified from the health record system. Results: The mean CAT score of the patients was 24.3±10.36 and the mean number of medications used by all participants was 5.87±2.84. A statistically significant and strong positive correlation was found between the total number of medications used and mMRC level and CAT score (r=0.630, p<0.01 and r=0.717, p<0.01, respectively). Conclusion: When prescribing medications by family physicians, especially in primary care, a holistic approach should be taken, taking into account all medications used by the patients, COPD symptoms should be reviewed; if polypharmacy proves to be inevitable, rational choices should be made and the medication burden should be reduced by prioritizing certain medications.

Özet

Amaç: Çoklu ilaç kullanımının, Kronik Obstrüktif Akciğer Hastalığı (KOAH) semptomları üzerine etkisini araştırmaktır. Gereç ve Yöntemler: Bu tanımlayıcı kesitsel çalışmaya Şubat- 2025 ve Nisan-2025 tarihleri arasında Kırıkkale Tıp Fakültesi Aile Hekimliği ve Göğüs Hastalıkları Anabilim Dallarına başvuran 50 yaş ve üzeri 96 hasta dâhil edilmiştir. KOAH semptom derecesini değerlendiren Değiştirilmiş Tıbbi Araştırma Konseyi ölçeği (mMRC) ve S76 KOAH değerlendirme testi puanı (CAT) ile beraber sosyodemografik verileri içeren form da hastalar ile yüz yüze görüşülerek doldurulmuştur. Görüşme sırasında hastalardan kendilerine bir doktor tarafından reçete edilen tüm ilaçları belirtmeleri istenmiş ve bunlar sağlık kayıt sisteminden doğrulanmıştır. Bulgular: Hastaların ortalama CAT skoru 24,3±10,36 ve tüm katılımcıların ortalama kullandığı ilaç sayısı 5,87±2,84 olarak saptanmıştır. Toplam kullanılan ilaç sayısı ile mMRC düzeyi ve CAT skoru arasında istatistiksel olarak anlamlı düzeyde ve güçlü bir pozitif korelasyon bulundu (r=0,630, p<0,01 ve r=0,717, p<0,01 sırasıyla). Sonuç: Özellikle birinci basamakta aile hekimleri tarafından ilaç reçete edilirken, bütüncül bir yaklaşımla hastanın kullandığı tüm ilaçlar göz önüne alınarak karar verilmeli, KOAH semptomları gözden geçirilmeli, çoklu ilaç kullanımının kaçınılmaz olduğu kanıtlanırsa, akılcı seçimler yapılmalı ve belirli ilaçlara öncelik verilerek, ilaç yükü azaltılmalıdır.

🔖

Cite This Article

Derhem, B., Kızmaz, M., Kaynar, A., Polat, M. S., Sokuoğlu, S., Çopur, D. E. (2025). The Effect of Polypharmacy on Chronic Obstructive Pulmonary Disease Symptoms: An Observational Study. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, Cilt: 27 Sayı: 3, 324–329. https://doi.org/10.24938/kutfd.1725178

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (25)

  1. Celli B, Fabbri L, Criner G, et al. Definition and nomenclature of chronic obstructive pulmonary disease: Time for its revision. Am J Respir Crit Care Med. 2022;206(11):1317–1325.
  2. Adeloye D, Song P, Zhu Y, Campbell H, Sheikh A, Rudan I. Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis. Lancet Respir Med. 2022;10(5):447–458.
  3. Varmaghani M, Dehghani M, Heidari E, Sharifi F, Saeedi Moghaddam S, Farzadfar F. Global prevalence of chronic obstructive pulmonary disease: systematic review and meta-analysis. East Mediterr Health J. 2019:25(1):47–57.
  4. Ntritsos G, Franek J, Belbasis L, et al. Gender-specific estimates of COPD prevalence: a systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis. 2018;13:1507–1514.
  5. Jones PW, Harding G, Berry P, Wiklund I, Chen WH, Kline Leidy N. Development and first validation of the COPD Assessment Test. Eur Respir J. 2009;34(3):648–654.
  6. Casaburi R. Activity promotion: a paradigm shift for chronic obstructive pulmonary disease therapeutics. Proc Am Thorac Soc. 2011;8(4):334-337.
  7. Guthrie B, Makubate B, Hernandez-Santiago V, Dreischulte T. The rising tide of polypharmacy and drug-drug interactions: population database analysis 1995–2010. BMC Med. 2015;13(1):74.
  8. Bourgeois FT, Shannon MW, Valim C, Mandl KD. Adverse drug events in the outpatient setting: an 11-year national analysis. Pharmacoepidemiol Drug Saf. 2010;19(9):901-910.
  9. Johnell K, Klarin I. The relationship between number of drugs and potential drug-drug interactions in the elderly: a study of over 600,000 elderly patients from the Swedish Prescribed Drug Register. Drug Saf. 2007;30(10):911-918.
  10. Westerik JAM, Metting EI, Van Boven JFM, Tiersma W, Kocks JWH, Schermer TR. Associations between chronic comorbidity and exacerbation risk in primary care patients with COPD. Respir Res. 2017;18(1):31.
  11. Franssen FM, Spruit MA, Wouters EF. Determinants of polypharmacy and compliance with GOLD guidelines in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2011;6:493-501.
  12. Hanlon P, Nicholl BI, Jani BD, et al. Examining patterns of multimorbidity, polypharmacy and risk of adverse drug reactions in chronic obstructive pulmonary disease: a cross-sectional UK Biobank study. BMJ Open. 2018;8(1):e018404.
  13. Derhem B, Özsari S. Frailty and polypharmacy in primary care. Biol Res Nurs. 2023;25(4):658–663.
  14. Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. The Lancet. 2013;381(9868):752–762.
  15. Chou YY, Lee YS, Lin CS, et al. Gender-specific linkages: frailty, polypharmacy, anti-cholinergic burden, and 5-year mortality risk—a real-world analysis. PeerJ. 2023 21;11:e16262.
  16. Global Strategy For Prevention, Diagnosis And Management of Copd: 2025 Report, Erişim Tarihi: 29.04.2025: https://goldcopd.org/2025-gold-report.
  17. Bestall JC, Paul EA, Garrod R, Garnham R, Jones PW, Wedzicha JA. Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease. Thorax. 1999;54(7):581–586.
  18. Alwafi H, Naser AY, Ashoor DS, et al. Prevalence and predictors of polypharmacy and comorbidities among patients with chronic obstructive pulmonary disease: a cross-sectional retrospective study in a tertiary hospital in Saudi Arabia. BMC Pulm Med. 2024 14;24(1):453.
  19. Sirois C, Ouali A, Simard M. Polypharmacy among older individuals with COPD: Trends between 2000 and 2015 in Quebec, Canada. COPD J Chronic Obstr Pulm Dis. 2019 4;16(3–4):234–239.
  20. Gutierrez-Valencia M, Izquierdo M, Cesari M, et al. The relationship between frailty and polypharmacy in older people: a systematic review. Br J Clin Pharmacol. 2018;84:1432–1444.
  21. Fried TR, O’Leary J, Towle V et al. Health outcomes associatedwith polypharmacy in community-dwelling older adults: a sys-tematic review. J Am Geriatr Soc. 2014;62:2261–2272.
  22. Sganga F, Landi F, Ruggiero C, et al. Polypharmacy and healthoutcomes among older adults discharged from hospital: resultsfrom the CRIME study. Geriatr Gerontol Int. 2015;15:141–146.
  23. Ierodiakonou D, Theodorou E, Sifaki-Pistolla D, et al. Clinical characteristics and outcomes of polypharmacy in chronic obstructive pulmonary disease patients: A cross-sectional study from Crete, Greece. Clin Respir J. 2021;15(12):1310-1319.
  24. Hanlon P, Nicholl BI, Jani BD, et al. Examining patterns ofmultimorbidity, polypharmacy and risk of adverse drug reac-tions in chronic obstructive pulmonary disease: a cross-sectional UK Biobank study. BMJ Open. 2018;8(1):e018404.
  25. Franssen FM, Spruit MA, Wouters EFM. Determinants ofpolypharmacy and compliance with GOLD guidelinesin patients with chronic obstructive pulmonary disease. IntJ COPD. 2011;6(1):493-501.