Journals / Fırat Tıp Dergisi / 2026 / Cilt: 14 Sayı: 3

Does In-Situ Saphenous Vein Graft Harvesting Decrease Intimal Injury in Coronary Bypass Surgery

Koroner Baypasta İn-situ Safen Ven Grefti Hazırlanması İntimal Hasarı Azaltır mı?

Pages
163–166
Publication Date
2009-06-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: It was found that the median scores of pathological injury were 2 in both groups.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Surgical manuplations during harvesting saphenous vein graft (SVG) and application of organ bath for CABG causes intimal injury.
📊
Key Findings & Data:A prospective study was performed with the postulation that in-situ harvesting technique would protect the graft from ischemic injury and decrease the intimal injury on of the endotelium.
💡
Conclusion & Impact:Results: It was found that the median scores of pathological injury were 2 in both groups.
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:İntimal hasar · in-situ safen ven grefti · CABG

Abstract

Objective: Surgical manuplations during harvesting saphenous vein graft (SVG) and application of organ bath for CABG causes intimal injury. A prospective study was performed with the postulation that in-situ harvesting technique would protect the graft from ischemic injury and decrease the intimal injury on of the endotelium. Materials and Methods: This study includes consecutive forty patients who underwent SVG harvesting for CABG. Two group each consisting 20 patients were formed. In group-1, SVG was harvested using the conventional open technique and kept for 45 minutes in papaverine organ-bath. In group-2, SVG was harvested by the in-situ technique and kept within a sponge soaked with papaverine for 45 minutes. 1 cm samples were taken from the distal end of the graft for the histopathological examination and were scored under light microscopy. Chi-square test was used for statistical analysis. Results: It was found that the median scores of pathological injury were 2 in both groups. There was no statistical difference between the two groups in respect to the scores of pathological injury (p = 0.987). Mild-moderate degree intimal desquamation was found in the two groups. Conclusion: In-situ saphenous vein graft harvesting does not have any advatage over the conventional open technique with respect to intimal injury.

Özet

Amaç: Koroner bypass cerrahisi (CABG) sırasında safen ven grefti hazırlanırken gerek cerrahi manüplasyonlara bağlı, gerekse organ banyosunda iskemik ortamda bekletilmeye bağlı intimal hasar oluşmaktadır. İn-situ teknik ile damar endotelinin iskemiden korunacağı ve intimal hasarın azalacağı öngörüsü ile prospektif bir çalışma planlandı. Gereç ve Yöntemler: CABG yapılacak ardışık 40 hastadan hazırlanan safen ven grefti çalışmaya alındı. Yirmişer hastadan oluşan iki grup oluşturuldu. Grup-1�de geleneksel �açık cilt kesiği tekniğiyle� safen ven grefti hazırlandı ve papaverinli organ banyosunda 45 dk. bekletildi. Grup-2�de in-situ teknikle safen ven grefti hazırlandı ve etrafına papaverinli spanç sarılarak 45 dk. bekletildi. Histopatolojik değerlendirme için, greftlerin distal uç kısmından 1 cm�lik safen parçası alındı. Doku örnekleri hemotoksilin-eosin ile boyanarak ışık mikroskopisinde incelendi ve histopatolojik olarak skorlandı. İstatistiksel değerlendirmede ki-kare testi kullanıldı. Bulgular: Her iki grupta da safen ven örneklerinden elde edilen patolojik hasar median skorları 2 bulundu ve istatistiksel fark saptanmadı (p = 0.987). Her iki grupta da hafif-orta derecede intimal desquamasyon saptandı. Sonuç: İn-situ teknikle safen ven grefti hazırlama geleneksel açık cilt kesiği tekniğiyle hazırlamaya intimal hasar bakımından üstün değildir.

🔖

Cite This Article

Özcan, A. V., Bir, F., Gökşin, İ., Saçar, M., Önem, G., Baltalarlı, A. (2009). Does In-Situ Saphenous Vein Graft Harvesting Decrease Intimal Injury in Coronary Bypass Surgery. Fırat Tıp Dergisi, Cilt: 14 Sayı: 3, 163–166. https://ajindex.com/articles/1207298

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Velthuis H, Jansen PGM, Oudemans-van Straaten HM, et al. Circulating endothelin in cardiac operation: influence of blood pressure and endotoxin. Ann Thorac Surg 1996; 61:904-8.
  2. Angelini GD, Basar Izzat M, Bryan AJ, Newby AC. External stenting reduces early medial and neointimal thickening in a pig model of arteriovenous bypass grafting. J thorac Cardiovasc Surg 1996; 112:79-84.
  3. Barker SG, Talbert A, Cottam S, Baskerville PA, Martin JF. Arterial intimal hyperplasia after occlusion of the adventitial vasa vasorum in the pig. Arterioscler Thromb 1993; 13:70-77.
  4. Çakır Ö, Oruç A, Erdem K, Yıldız F, Eren N. Safen ven hazırlanmasında sodyum nitroprussid ve papaverin kullanımı. Türk Göğüs Kalp Damar Cer Derg 2004; 12:35-39.
  5. Rosenfeldt FL, He GW, Buxton BF, Angus JA. Pharmocology of coronary artery bypass grafts. Ann Thorac Surg 1999; 67:878-888.
  6. Imagawa H, Taniguchi K, Takahashi T. Gene transfer with hemagglutinating virus of Japan liposome into human saphenous vein graft; preventive way against vein graft disease. Circulation 1996; 94:477.
  7. Mehda D, George SJ, Jeremy JY. External stenting reduces long-term medial and neointimal thickening and platelet derived growth factor expression in a pig model of arteriovenous bypass grafting. Nature Med 1998; 4:235-239.
  8. Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmerman GA, McEver RP. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 1998; 91:3527- 3561.
  9. Souza DSR, Christofersson RHB, Bomfim V, Filbey D. “No- touch” tecnique by using saphenous vein harvested with its surrounding tissue for coronary artery bypass grafting maintains an intact endothelium. Scand J Thorac Cardiovasc Surg 1999; 33:323-329.
  10. Tsui JCS, Souza DSR, Filbey D, Bomfim V, Dashwood MR.Preserved endothelial integrity and nitric oxide synthase in saphenous vein graft harvested by a “no-touch” tecnique. Br J Surg 2001; 88:1209-1215.
  11. Stooker W, Niessen HWM, Baidoshvili A, Wildevuur WR, Van Hinsberg VWM, Fritz J, Wildevuur CRH, Eijsman L. Perivenous support reduces early changes in human vein grafts:studies in whole blood perfused human vein segments. J Thorac Cardiovasc Surg 2001; 121:290-297.
  12. Kabul Tarihi: 01.06.2009