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Journals / Fırat Tıp Dergisi / 2026 / Cilt: 18 Sayı: 2

Histomorphological Examination of Age-Related Change in Rat Esophagus and Stomach

Sıçanlarda Özefagus ve Midede Yaşa Bağlı Değişimlerin Histomorfolojik Açıdan İncelenmesi

Elif Taşlıdere
Meltem Kuruş
Alper Kazancı
Ali Otlu
Pages
75–82
Publication Date
2013-04-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We observed that the thickness of esophagus epithelium and tunica muscularis were significantly increased by age in all groups (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: In this study, it was aimed that age-related morphological changes in rat esophagus and stomach was investigated with light microscopy.
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Key Findings & Data:Materials and Methods: In this study, 21 female Sprage-Dawley rats were used.
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Conclusion & Impact:We observed that the thickness of esophagus epithelium and tunica muscularis were significantly increased by age in all groups (p
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:Sıçan · Özefagus · Mide

Abstract

Objective: In this study, it was aimed that age-related morphological changes in rat esophagus and stomach was investigated with light microscopy. Materials and Methods: In this study, 21 female Sprage-Dawley rats were used. Rats were divided into three groups as follows. Group1:21 days old, Group2:2 month old and Group3:19 month old. At the end of the examination esophagus and stomach tissues were removed.The sections stained wiht hematoxylin-eosin and evaluated light microscopically. Results: The mean thickness of esophagus epithelium was measured. It was 31.85±5.7 μm in Group1, 40.95±6.7 μm in Group2 and 44.68±9.2 μm in Group3. The mean thickness of tunica muscularis in esophagus measured. It was 128.9±23.1 μm in Group 1, 207.8±38,5 μm in Group2 and 256.07±35.52 in Group3. We observed that the thickness of esophagus epithelium and tunica muscularis were significantly increased by age in all groups (p

Özet

Amaç: Bu çalışmada sıçan özefagus ve midelerinde yaşa bağlı olarak gelişen morfolojik değişikliklerin ışık mikroskobik açıdan incelenmesi amaçlandı. Gereç ve Yöntem: Çalışmamızda 21 adet dişi Spraque-Dawley sıçan kullanıldı. Sıçanlar, Grup 1: 21 günlük sıçanlar, Grup 2: 2 aylık sıçanlar ve Grup 3: 19 aylık sıçanlar olmak üzere 3 gruba ayrıldı. Deney sonunda çıkartılan özefagus ve mide dokuları rutin histolojik doku takibinden sonra parafine gömüldü. Kesitler Hematoksilen-eozin ile boyanıp ışık mikroskobunda incelendi. Bulgular: Çalışmamızda özefagus epitel kalınlığı Grup 1'de ortalama 31.85±5.7 μm, Grup 2'de 40.95±6.7 μm, Grup 3'de 44.68±9,2 μm olarak bulundu. Tunika muskularis kalınlığı Grup 1'de ortalama 128.9±23.1 μm, Grup 2'de 207.8±38.5 μm ve Grup 3'de 256.07±35.52 μm olarak tespit edildi. Sıçanlarda özefagusa ait epitel ve tunika muskularis kalınlığı ölçüldüğünde yaşlanmaya bağlı olarak kalınlığın anlamlı derecede arttığı gözlendi (p

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Cite This Article

Taşlıdere, E., Kuruş, M., Kazancı, A., Otlu, A. (2013). Histomorphological Examination of Age-Related Change in Rat Esophagus and Stomach. Fırat Tıp Dergisi, Cilt: 18 Sayı: 2, 75–82. https://ajindex.com/articles/1207088

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References (22)

  1. Williams PL, Bannister LH, Berry MM, et al. Embriyology and Development In: Collins P. Grays Anatomy. Churcill Livingstone Inc, New York 1995: 181-85.
  2. Moore KL, Persaud, T. V.N Klinik yönleri ile insan embriyolojisi. In: Yıldırım M, Okar İ, Dalçık H. ed. 1. Baskı, İstanbul: Nobel Matbaacılık, 2002: 212-13.
  3. Ovalle WK, Nahirney PC. Netter Temel Histoloji. In: Müftüoğlu S, Kaymaz F, Atilla P. Ankara: Palme Yayıncılık, 2009: 278-8
  4. Junqueria LC, Carneiro J. Temel Histoloji. In: Aytekin Y, Solakoğlu S. ed.8.baskı. İstanbul: Barış Kitapevi 1998: 280-7.
  5. Ross, MH, Pawlina W. Histology A Text and Atlas With correlated cell and molecular biology (5 ed). Baltimore: Lippincott Williams & Wilkins, 2006: 522-34.
  6. Abraham L, Kierszenbaum A. Histoloji ve hücre biyolojisi, patolojiye giriş. In: Demir R. Ankara: Palme Yayıncılık, 2006: 405Charlotte L. Ownby Veterinary Histology VMED 7123 Fall Semester 2004:4-5
  7. Carslon BM. Human embryology and developmental and developmental biology, fourth edition, Mosby Elsevier, Philadelphia: 2009: 362-64.
  8. Ergun GA, Miskovitz MD. Aging and the esophagus: Common pathologic conditions and their effect upon swallowing in the geriatric population. Dysphagia 1992; 7: 58-63.
  9. Gregersen H, Lu X, Zhao J. Physiological growth is associated with osephageal morphometric and biomechanical changes in rats. Neurogastroenterol Motil 2004; 16: 403-12.
  10. Hollander D, Tarnawski A, Stachura J, Gergely H. Morphologic changes in gastricrmicosa of aging rats. Dig Dis Sci 1989; 34: 1692-700.
  11. Menard D, Arsenault P. Maturation of human fetal esophagus maintained in organ culture. Anat Rec 1987; 217: 384-54.
  12. Sorkun HC, Özadamar S. A Study on the Prenatal and postnatal development of rat esophagus. T Klin J Med Sci 2002; 22.
  13. Cerimele D, Celleno, Serri F. Physiological changes in aging skin. Br J Dermatol 1990;13-20.
  14. Allı N. Deri yaşlanmasında hücresel ve moleküler mekanizmalar. T Kin J Kozmetoloji 1998; 1296-99.
  15. Tuncer I, Tosun M, Kalkan S, et al. Histomorphologic Evaluation of the development of the esophagus Between 17 and 32 Weeks old human fetusus. Erciyes Medical Journal 2005; 27: 152 de Souza RR, Moratelli HB, Borges N, Liberti EA. Ageinduced nerve cell loss in the myenteric plexus of the small intestine in man. Gerontology 1993; 39: 183-8.
  16. Eckardt VF, LeCompte PM, Volker F, Eckard T, Philip M. LeCompte Esophageal ganglia and smooth muscle in the elderly. Am J Dig Dis 1978; 23: 443-8.
  17. Ekinci N. Deney Hayvanları Anatomisi. 22-30 Ocak 2010 Deney Hayvanları Kullanım Sertifikası Eğitim Kursu Sunumu. Malatya: 2010.
  18. De Lemos C. The ultrastructure of endocrine cells in the corpus of the stomach of human fetuses. J Anat 1997; 148: 359-8
  19. Helander H. Ultrastructure and function of gastric parietal calls in the rat during development. Gastroenterology 1969; 56: 35-52.
  20. Penttıla A. The fine structure and dihydroxyphenylalanine uptake of the developing parietal cells of the rat Stomach. Z Anat. Entwickl 1970; 132: 34-49.
  21. Kammaraad A. The development of the gastrointestinal tract of the rat. Histogenesis of the epithelium of the stomach, small intestine and pancreas. J Morphol 1942; 70: 323.
  22. Goldstein I, Reece EA, Yarkoni S, Wan M, Gren JL, Hobbins JC. Growth of the fetal stomach in normal pregnancies. Obstet Gynecol 1987; 70: 641-44.