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Journals / Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi / 2019 / Volume: 33 Issue: 3

RELATIONSHIP BETWEEN VITAMIN D LEVEL AND PARAOXONASE 1 ENZYME ACTIVITY

D vitamini düzeyi ile paraoksonaz 1 enzim aktivitesi arasındaki ilişki

Özge Dokuzlar(DOKUZ EYLÜL ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ, GERİATRİ ANABİLİM DALI)0000-0001-7079-9696
Mehmet Calan(İzmir Bozyaka Eğitim ve Araştırma Hastanesi Endokrinoloji Kliniği)0000-0002-5614-0710
Ali Şişman(DOKUZ EYLÜL ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALI)0000-0002-9266-0844
Sinem Kocaer(DOKUZ EYLÜL ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, İÇ HASTALIKLARI ANABİLİM DALI, ROMATOLOJİ BİLİM DALI)0000-0002-5481-0776
Fırat Bayraktar(ENDOKRİN VE METABOLİZMA HASTALIKLARI BİLİM DALI)0000-0001-7800-2530
Pages
199–206
Publication Date
2020-02-06
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: There was no relationship between vitamin D levels and PON1 enzyme activity.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Vitamin D deficiency has a negative effect on lipid metabolism and increases cardiovascular risk.
📊
Key Findings & Data:Paraoxonase-1 (PON1) enzyme activity is one of the determinants of high-density lipoprotein (HDL) activity.
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Conclusion & Impact:Conclusion: There was no relationship between vitamin D levels and PON1 enzyme activity.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:D vitamini eksikliği · HDL kolesterol · lipid metabolizması

Abstract

Objective: Vitamin D deficiency has a negative effect on lipid metabolism and increases cardiovascular risk. Paraoxonase-1 (PON1) enzyme activity is one of the determinants of high-density lipoprotein (HDL) activity. The aim of this study was to investigate whether vitamin D level and PON1 activity are related. Material and Method: 200 healthy individuals between 18-50 years of age with similar demographic characteristics were included. Individuals included in the study were divided into four groups as vitamin D levels: sufficient (>30 ng/dL), mild-moderate deficiency (20-30 ng/dL), deficiency (10-20 ng/dL) and severe deficiency (<10 ng/dL). PON1 enzyme activity of these four groups was compared. Plasma PON1 enzyme activity was measured by ELISA. Results: Of the individuals included to this study, 132 were female and 68 were male. PON1 enzyme activity did not show any statistically significant difference between these 4 groups. There was not any relationship between PON1 enzyme activity and other parameters. Conclusion: There was no relationship between vitamin D levels and PON1 enzyme activity.

Özet

Amaç: D vitamini eksikliği lipid metabolizması üzerine olumsuz etki oluşturmakta ve kardiyovasküler riski artırmaktadır. Paraoksonaz-1 (PON1) enzim aktivitesi, yüksek dansiteli lipoprotein (HDL) aktivitesini belirleyen faktörlerden birisidir. Bu araştırmada, D vitamin düzeyi ile PON1 aktivitesi arasında ilişkili olup olmadığının incelenmesi amaçlandı. Gereç ve Yöntem: Çalışmamıza 18-50 yaş arası, benzer demografik özelliklere sahip 200 sağlıklı birey alındı. Araştırmaya dahil edilen bireyler serum 25(OH)D vitamini düzeyine göre D vitamini düzeyi normal (>30 ng/dL), D vitamin eksikliği olan (20-30 ng/dL), D vitamin yetmezliği olan (10-20 ng/dL) ve derin D vitamin yetmezliği olan (<10 ng/dL) bireyler olarak 4 gruba ayrıldı. Bu dört grup arasında PON1 enzim aktivitesi düzeyi karşılaştırıldı. Plazma PON1 enzim aktivitesi ELISA yöntemi ile ölçüldü. Bulgular: Araştırmamıza dahil olan bireylerin 132’si kadın ve 68’i erkek idi. PON1 enzim aktivitesi 4 grup arasında istatistiksel anlamlı bir fark oluşturmadı. Ayrıca PON1 enzim aktivitesi ile diğer parametreler arasında da herhangi bir ilişki saptanmadı. Sonuç: D vitamini düzeyi ile PON1 enzim aktivitesi arasında bir ilişki saptanmadı.

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Cite This Article

Dokuzlar, Ö., Calan, M., Şişman, A., Kocaer, S., Bayraktar, F. (2020). RELATIONSHIP BETWEEN VITAMIN D LEVEL AND PARAOXONASE 1 ENZYME ACTIVITY. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, Volume: 33 Issue: 3, 199–206. https://doi.org/10.5505/deutfd.2019.63644

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