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Journals / Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi / 2026 / Volume: 12 Issue: 1

The Effect Of Serotonın Reuptake Inhıbıtor Use On Restless Legs Syndrome In Chıldren

ÇOCUKLARDA SEROTONİN GERİ ALIM İNHİBİTÖRÜ KULLANIMININ HUZURSUZ BACAK SENDROMU ÜZERİNE ETKİSİ

Derya Yavuz Demiray(Hatay Mustafa Kemal University)0000-0003-2683-3062
Seda Aybüke Sarı(Hatay Mustafa Kemal University)0000-0003-4793-0662
Mehmet Erdem(HATAY MUSTAFA KEMAL UNIVERSITY)0000-0001-5671-1213
Pages
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Publication Date
2025-03-26
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results indicated a potential link between SSRI use and the onset of RLS symptoms.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This research intends to investigate the relationship between selective serotonin reuptake inhibitors (SSRIs) and the occurrence rate of Restless Legs Syndrome (RLS) among pediatric and adolescent populations diagnosed with depression and/or anxiety disorders.
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Key Findings & Data:Materials and Methods: This retrospective study examined patients between the ages of 10 and 17 who had been prescribed one of the following selective serotonin reuptake inhibitors (SSRIs): fluoxetine, sertraline, or escitalopram.
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Conclusion & Impact:The results indicated a potential link between SSRI use and the onset of RLS symptoms.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Restless Legs Syndrome · Serotonin Reuptake Inhibitors · Children

Abstract

Objective: This research intends to investigate the relationship between selective serotonin reuptake inhibitors (SSRIs) and the occurrence rate of Restless Legs Syndrome (RLS) among pediatric and adolescent populations diagnosed with depression and/or anxiety disorders. Materials and Methods: This retrospective study examined patients between the ages of 10 and 17 who had been prescribed one of the following selective serotonin reuptake inhibitors (SSRIs): fluoxetine, sertraline, or escitalopram. Exclusion criteria included patients with iron deficiency anemia, diabetes mellitus, renal disorders, spinal cord conditions, those receiving antihistaminic or antipsychotic medications, and individuals with other psychiatric or neurological disorders. The study meticulously recorded demographic information, medical histories, ferritin levels, vitamin B12 levels, and a family history of restless legs syndrome (RLS). Furthermore, the severity of RLS was evaluated using a specific scale for patients diagnosed with the condition. Results: Among the 40 children analyzed, 10% developed RLS. The results indicated a potential link between SSRI use and the onset of RLS symptoms. No significant relationship was found between RLS and hemoglobin, ferritin, or vitamin B12 levels. Half of the RLS patients had a family history of RLS. Conclusion: The results indicate a possible association between the administration of SSRIs and the emergence of RLS in pediatric and adolescent populations. It is advisable to conduct additional studies with an expanded sample size.

Özet

Amaç: Bu araştırma, seçici serotonin geri alım inhibitörleri (SSRI'lar) ile depresyon ve/veya anksiyete bozuklukları tanısı alan çocuk ve ergen popülasyonlarında Huzursuz Bacak Sendromu (HBS) görülme oranı arasındaki ilişkiyi incelemeyi amaçlamaktadır. Gereç ve Yöntemler: Bu retrospektif çalışmada, fluoksetin, sertralin veya essitalopram gibi seçici serotonin geri alım inhibitörlerinden (SSRI'lar) birini kullanmış 10-17 yaş arası hastalar incelenmiştir. Dışlama kriterleri arasında demir eksikliği anemisi, diyabet, böbrek hastalıkları, omurilik rahatsızlıkları, antihistaminik veya antipsikotik ilaç kullananlar ve diğer psikiyatrik ya da nörolojik bozukluklara sahip hastalar yer almıştır. Çalışmada, demografik bilgiler, tıbbi geçmiş, ferritin seviyeleri, vitamin B12 seviyeleri ve ailede huzursuz bacak sendromu (HBS) öyküsü kaydedilmiştir. Ayrıca, HBS tanısı konulan hastaların durumunun şiddeti HBS şiddet ölçeği ile değerlendirilmiştir. Bulgular: Analiz edilen 40 çocuk arasında %10’unda HBS gelişmiştir. Sonuçlar, SSRI kullanımının HBS semptomlarının ortaya çıkışıyla potansiyel bir bağlantısı olabileceğini göstermiştir. HBS ile hemoglobin, ferritin veya vitamin B12 seviyeleri arasında anlamlı bir ilişki bulunmamıştır. HBS tanısı alan hastaların yarısında HBS aile öyküsü tespit edilmiştir. Sonuç: Sonuçlar, SSRI kullanımının çocuk ve ergen popülasyonlarında HBS gelişimi ile olası bir ilişkiyi işaret etmektedir. Daha geniş bir örneklem büyüklüğüyle ek çalışmalar yapılması tavsiye edilmektedir.

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Cite This Article

Demiray, D. Y., Sarı, S. A., Erdem, M., *, D. Y. D. (2025). The Effect Of Serotonın Reuptake Inhıbıtor Use On Restless Legs Syndrome In Chıldren. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, Volume: 12 Issue: 1. https://doi.org/10.34087/cbusbed.1627593

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