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Journals / Anatomy / 2026 / Volume: 9 Issue: 2

Reflex influences on oropharyngeal swallowing

Cumhur Ertekin
Journal
Anatomy
Pages
—
Publication Date
2015-09-10
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These kind of reflexes were emphasized in this review.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Swallowing is a complex sensorimotor behaviour involving the coordinated and reflex contraction and inhibition of the musculature located in and around the mouth, larynx, pharynx and esophagus.
📊
Key Findings & Data:Voluntary swallowing is under the the control of the cerebral cortex and other subcortical structures, but the main locations are the nucleus tractus solitarius and nucleus ambiguus, and their neural network of central pattern generator.
💡
Conclusion & Impact:These kind of reflexes were emphasized in this review.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:central pattern generator · larynx · pharynx

Abstract

Swallowing is a complex sensorimotor behaviour involving the coordinated and reflex contraction and inhibition of the musculature located in and around the mouth, larynx, pharynx and esophagus. Voluntary swallowing is under the the control of the cerebral cortex and other subcortical structures, but the main locations are the nucleus tractus solitarius and nucleus ambiguus, and their neural network of central pattern generator. In spite of these central controls, there are some intrinsic reflex actions between three phases of swallowing. These kind of reflexes were emphasized in this review.

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Cite This Article

Ertekin, C. (2015). Reflex influences on oropharyngeal swallowing. Anatomy, Volume: 9 Issue: 2. https://doi.org/10.2399/ana.15.005

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References (151)

  1. Miller AJ. Deglutition. Physiol Rev 1982;62:129–84.
  2. Thexton AJ, Crompton AW. The control of swallowing. In:
  3. Linden RWA, ed. Frontiers of Oral Biology. Basel: Karger; 1998;
  4. p. 168–222.
  5. Jean A. Brainstem control of swallowing: neuronal network and
  6. cellular mechanisms. Physiol Rev 2001;81:929–69.
  7. Ertekin C, Aydogdu I. Neurophysiology of swallowing. Clin
  8. Neurophysiol 2003;114:2226–44.
  9. Lear CSC, Flanagan JBJ, Moorrees CFA. The frequency of deglutition
  10. in man. Arch Oral Biol 1965;10:83–99.
  11. Calloway S, Fonagy D, Pounder R. Frequency of swallowing in
  12. duodenal ulceration and hiatus hernia. Br Med J 1982;285:23–4.
  13. Kapila YV, Doddo WJ, Helm JF, Hogan WJ. Relationship between
  14. swallow rate and salivary flow. Dig Dis Sci 1984;29:528–33.
  15. Lagerlöf F, Dawes C. The volume of saliva in the mouth before
  16. and after swallowing. J Dent Res 1984;63:618–21.
  17. Pehlivan M, Yüceyar N, Ertekin C, Celebi G, Ertafl M, Kalayci T,
  18. Aydo¤du I. An electronic device measuring the frequency of spontaneous
  19. swallowing: digital phagometer. Dysphagia 1996;11:259–64.
  20. Rudney JD, Larson CJ. The prediction of saliva swallowing frequency
  21. in humans from estimates of salivary flow rate and the volume
  22. of saliva swallowed. Arch Oral Biol 1995;40:507–12.
  23. Ertekin C. Voluntary versus spontaneous swallowing in man.
  24. Dysphagia 2011;26:183–92.
  25. Ertekin C, Kiylioglu N, Tarlaci S, Turman AB, Secil Y, Aydogdu
  26. I. Voluntary and reflex influences on the initiation of swallowing
  27. reflex in man. Dysphagia 2001;16:40–7.
  28. Miller JL, Sonies BC, Macedonia C. Emergence of oropharyngeal,
  29. laryngeal and swallowing activity in the developing fetal upper
  30. aerodigestive tract: an ultrasound evaluation. Early Hum Dev 2003;:61–87.
  31. Poleg D, Goldman JA. Fetal deglutition: a study of the anencephalic
  32. fetus. Eur J Obstet Gynecol Reprod Biol 1978;8:133–6.
  33. Pritchard JA. Deglutition by normal and anencephalic fetus. J Obstet
  34. Gynecol 1965; 25:289–97.
  35. Martin, RE Neuroplasticity and swallowing. Dysphagia 2009;24:
  36. Nishino T. Swallowing as a protective reflex for the upper respiratory
  37. tract. Anesthesiology 1993;79:588–601.
  38. Shaker R, Ren J, Zamir Z, Sarna S, Liv J, Sui Z. Effect of aging,
  39. position and temperature on the threshold volume triggering pharyngeal
  40. swallows. 1994;107:396–402.
  41. Doty RW, Bosma JF. An electromyographic analysis of reflex deglutition.
  42. J Neurophysiol 1956;19:44–60.
  43. Thexton AJ, Crompton AW, German RZ. Electromyographic
  44. activity during the reflex pharyngeal swallow in the pig: Doty and
  45. Bosma (1956) revisited. J Appl Physiol 2007;102:587–600.
  46. Dodds WJ, Hogan WJ, Reid DP, Stewart ET, Arndorfer RC. A
  47. comparison between primary esophageal peristalsis following wet
  48. and dry swallows. J Appl Physiol 1973;35:851–7.
  49. Hollis JB, Castell DO. Effect of dry swallows and wet swallows of
  50. different volumes on esophageal peristalsis. J Appl Physiol;38:1161–4.
  51. Ertekin C, Aydogdu I. Electromyography of human cricopharyngeal
  52. muscle of the upper esophageal sphincter. Muscle Nerve 2002;:729–39.
  53. Miller AJ. The neurobiology of swallowing and dysphagia. Dev
  54. Disabil Res Rev 2008;14:77–86.
  55. Ertekin C, K›yl›o¤lu N, Tarlac› S, Keskin A, Aydo¤du I. Effect of
  56. mucosal anaesthesia on oropharyngeal swallowing. Neurogastroenterol
  57. Motil 2000;12:567–72.
  58. Ali GN, Laundl TM, Wallace KL, Shaw DW, deCarle DJ, Cook
  59. IJ. Influence of mucosal receptors on deglutive regulation of pharyngeal
  60. and upper esophageal sphincter function. Am J Physiol;267:G644–9.
  61. Mansson I, Sandberg N. Effect of surface anesthesia on deglutition
  62. in man. Laryngoscope 1974;84:427–37.
  63. Mansson I, Sandberg N. Salivary stimulus and swallowing reflex in
  64. man. Acta Otolaryngol 1975;79:445–50.
  65. Jean A, Dallaporta M. Electrophysiologic characterization of the
  66. swallowing pattern generator in the brainstem. GI Motility Online; DOI: http://dx.doi.org/10.1038/gimo9
  67. Jean A, Car A, Roman C. Comparison of activity in pontine versus
  68. medullary neurons during swallowing. Exp Brain Res 1975;22:211–
  69. Jafari S, Prince RA, Kim DY, Paydarfar D. Sensory regulation of
  70. swallowing and airway protection: a role for the internal superior
  71. laryngeal nerve in humans. J Physiol 2003;550:287–304.
  72. Lowell SY, Poletto CJ, Bethany RKC, Reynolds RC, Simonyan K,
  73. Ludlow CL. Sensory stimulation activates both motor and sensory
  74. components of the swallowing system. Neuroimage 2008;42:285–95.
  75. Miller AJ. The neuroscientific principles of swallowing and dysphagia.
  76. San Diego (CA): Singular Publication Group; 1999.
  77. Jean A. Brainstem organisation of the swallowing network. Brain
  78. Behav Evol 1984;25:109–16.
  79. Jean A. Control of the central swallowing program by inputs from the
  80. principal receptors. A review. J Auton Nerv Syst 1986;10:225–33.
  81. Logemann JA. Evaluation and treatment of swallowing disorders.
  82. nd ed. Austin (TX): Pro Ed; 1998.
  83. Palmer JB, Rudin NJ, Lara G, Crompton AW. Coordination of
  84. mastication and swallowing. Dysphagia 1992;7:187–200.
  85. Pouderoux P, Logemann JA, Kahrilas PJ. Pharyngeal swallowing
  86. elivcited by fluid infusion: role of volition and vallecular containment.
  87. Am J Physiol 1996;270:G347–54.
  88. Dua KS, Ren J, Bardon E, Xie P, Shaker R. Coordination of deglutive
  89. glottal function and pharyngeal bolus transit during normal
  90. eating. Gastroenterology 1997;112:73–83.
  91. Hiiemae KM, Palmer JB. Food transport and bolus formation during
  92. complete feeding sequences on foods of different initial consistencies.
  93. Dysphagia 1999;14:31–42.
  94. Chi-Fishman G, Sonies BC. Motor strategy in rapid sequential
  95. swallowing: New insights. J Speech Lang Hear Res 2000;43:1481–
  96. Daniels SK, Foundas AL. Swallowing physiology of sequential
  97. straw drinking. Dysphagia 2001;16:176–82.
  98. Daniels SK, Grey D, Hadskey LD, Legendre C, Priestly DH,
  99. Rosenbek JC, Foundas AC. Mechanism of sequential swallowing
  100. during straw drinking in healty young and older adults. J Speech
  101. Lang Hear Res 2004;47:33–45.
  102. Kessler JP, Jean A. Identification of medullary swallowing regions
  103. in the rat. Exp Brain Res. 1985;57:256–63.
  104. Ertekin C, Celik M, Seçil Y, Tarlaci S, Kiylio¤lu N, Aydo¤du I.
  105. The electromyographic behaviour of the thyroarytenoid muscle
  106. during swallowing. J Clin Gastroenterol 2000;30:274–80.
  107. Ertekin C, Pehlivan M, Aydo¤du I, Ertafl M, Uluda¤ B, Celebi G,
  108. Colako¤lu Z, Sa¤duyu A, Yüceyar N. An electrophysiological
  109. investigation of deglutition in man. Muscle Nerve1995;18:1177–
  110. Ludlow CL, Vanpelt F, Koda J. Characteristics of late responses to
  111. superior laryngeal nerve stimulation in humans. Ann Otol Rhinol
  112. Laryngol 1992;101:127–34.
  113. Sasaki CT, Suzuki M. Laryngeal reflexes in cat, dog and man. Arch
  114. Otolaryngol 1976;102:400–2.
  115. Barkmeier JM, Bielamowicz S, Takeda N, Ludlow L. Modulation
  116. of laryngeal responses to superior laryngeal nerve stimulation by
  117. volutional swallowing in awake humans. J Neurophysiol;83:1264–72.
  118. Esaki H, Toshiro U, Selh T, Shin T. Characteristics of laryngeal
  119. receptors analysed by presynaptic recording from the cat medulla
  120. oblongata. Auris Nasus Larynx 1997;24:73–93.
  121. Celik M, Alkan Z, Ercan I, Ertaflo¤lu H, Alk›m C, Erdem L
  122. Turgut S, Ertekin C. Cricopharyngeal muscle electromyography
  123. in laryngopharyngeal reflux. Laryngoscope 2005;115:138–48.
  124. Andreatta RD, Mann EA, Poletto CJ, Ludlow CL. Mucosal afferents
  125. mediate laryngeal adductor responses in the cat. J Appl Physiol;93:1622–9.
  126. Shaker R, Dodds WJ, Dantas RO, Hogan WJ, Arndorfer RC.
  127. Coordination of deglutitive glottic closure with oropharyngeal
  128. swallowing. Gastroenterology 1990;98:1478–84.
  129. Martin BJW, Logemann JA, Shaker R, Dodds WJ. Coordination
  130. between respiration and swallowing: respiratory phase relationship
  131. and temporal integration. J Appl Physiol 1994;76:714–24.
  132. Curtis DJ, Cruess DF, Dachman AH, Maso E. Timing in the normal
  133. pharyngeal swallow: prospective selection and evaluation of 18
  134. normal asymptomatic patients investigation. Invest Radiol 1984;:523–9.
  135. McConnell FM, Cerenko D, Jackson RT, Guffin Tn Jr. Timing of
  136. major event of pharyngeal swallowing. Arch Otolaryngol Head
  137. Neck Surg 1988;114:1413–8.
  138. Kendall KA, McKenzie S, Leonard RJ, Gonçalves MI, Walker A.
  139. Timing events in normal swallowing: a videofluoroscopic study.
  140. Dysphagia 2000;15:74–83.
  141. Kendall KA. Oropharyngeal swallowing variability. Laryngoscope;112:547–51.
  142. Kendall KA, Leonard RJ, McKenzie SW. Sequence variability
  143. during hypopharyngeal bolus transit. Dysphagia 2003;18:85–91.
  144. Ohmae Y, LogemannJA, Kaiser P, Hansen DG, Kahrilas PJ.
  145. Timing of glottic closure during normal swallow. Head Neck;17:394–402.
  146. Celik Gokyigit M, Kuloglu Pazarci N, Ercan I, Seker S, Turgut S,
  147. Ertekin C. Identification of distinct swallowing patterns for different
  148. bolus volumes. Clin Neurophysiol 2009;120:1750–4.
  149. Dozier TS, Brodsky MB, Michel Y, Walters Jr BC, Martin-Harris
  150. B. Coordination of swallowing and respiration in normal sequential
  151. cup swallows. Laryngoscope 2006;116:489–93.