Journals / Anatomy / 2026 / Volume: 20 Issue: 1

A Topology For Cells In Virchow’s Schleimgewebe?

Hanno Steinke(Institut für Anatomie)0000-0002-7117-9330
Journal
Anatomy
Pages
—
Publication Date
2026-05-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As further evidence for a mucus topology, we can conclude that topological thinking is clinically very successful in cancer treatment.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Mucus as an anatomical entity has been unjustly overlooked in bioscience, despite being recognised as an influential microenvironment for cells or hosts with disease-causing properties.
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Key Findings & Data:In addition to his description of cell function, Rudolf Virchow considered the effect of mucus, to which we owe today’s thinking on cell biology.
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Conclusion & Impact:As further evidence for a mucus topology, we can conclude that topological thinking is clinically very successful in cancer treatment.
🔬Design:Other
📍Scope:Comprehensive Sample
⚙️Variables:biofactors · biomarkers · cancer

Abstract

Mucus as an anatomical entity has been unjustly overlooked in bioscience, despite being recognised as an influential microenvironment for cells or hosts with disease-causing properties. In addition to his description of cell function, Rudolf Virchow considered the effect of mucus, to which we owe today’s thinking on cell biology. He coined the term ‘Schleimgewebe’. These spaces of mucus, formed by ‘connective tissue’ (wrongly ‘fasciae’, formerly described as ‘tela’), can be revealed without cells by Ott’s method. The fact that correct cells redevelop locally through blood perfusion in determined spaces is further evidence of local effectiveness of Schleimgewebe. As further evidence for a mucus topology, we can conclude that topological thinking is clinically very successful in cancer treatment.

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Cite This Article

Steinke, H. (2026). A Topology For Cells In Virchow’s Schleimgewebe?. Anatomy, Volume: 20 Issue: 1. https://ajindex.com/articles/1189898

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References (29)

  1. Hoffbauer CH. Dissertatio inauguralis medica de ignobili muco [Dissertatio. Praes.: Joanne Junckero]. Halle: Halae Magdeburgicae, 1734.
  2. Virchow R. Vorlesungen über Pathologie. Erster Band: Die Cellular-Pathologie in ihrer Begründung auf physiologische und pathologische Gewebelehre. 4 Aufl. Berlin: August Hirschwald; 1871.
  3. Kufe DW. Mucins in cancer: function, prognosis and therapy. Nat Rev Cancer 2009;9:874–85.
  4. Luo G, Liu N. An integrative theory for cancer (Review). Int J Mol Med 2019;43:647–56.
  5. Soto AM, Sonnenschein C. The tissue organization field theory of cancer: a testable replacement for the somatic mutation theory. Bioessays 2011;33:332–40.
  6. Jassim A, Rahrmann EP, Simons BD, Gilbertson RJ. Cancers make their own luck: theories of cancer origins. Nat Rev Cancer 2023;23:710–24.
  7. Cox TR. The matrix in cancer. Nat Rev Cancer 2021;21:217–38.
  8. Editorial. The global challenge of cancer. Nat Cancer 2020;1:1–2.
  9. Höckel M. Morphogenetic fields of embryonic development in locoregional cancer spread. Lancet Oncol 2015;16:e148–51.
  10. Höckel M, Wolf B, Schmidt K, Mende M, Aktas B, Kimmig R, Dornhöfer N, Horn LC. Surgical resection based on ontogenetic cancer field theory for cervical cancer: mature results from a single-centre, prospective, observational, cohort study. Lancet Oncol 2019;20:1316–26.
  11. Falconer H, Norberg-Hardie A, Salehi S, Alfonzo E, Weydandt L, Dornhöfer N, Wolf B, Höckel M, Aktas B. Oncologic outcomes after Total Mesometrial Resection (TMMR) or treatment according to current international guidelines in FIGO (2009) stages IB1-IIB cervical cancer: an observational cohort study. EClinicalMedicine 2024;73:102696.
  12. Alvanos A, Bechmann I, Steinke H. Presenting embryologically defined peripancreatic compartments and fusion planes in the search for pancreatic cancer fields. Eur J Surg Oncol 2024;50:108272.
  13. Alvanos A, Schubert E, Winter K, Steinke H. Unraveling the pancreatic anlagen: validating a manual dissection protocol with immunohistochemical staining for pancreatic polypeptide in a human cadaver study. Biomedicines 2025;13:1318.
  14. Stolzenburg J-U, Schwalenberg T, Horn L-C, Neuhaus J, Constantinides C, Liatsikos EN. Anatomical landmarks of radical prostatecomy. Eur Urol 2007;51:629–39.
  15. Stolzenburg JU, Rabenalt R, Do M, Kallidonis P, Liatsikos EN. Endoscopic extraperitoneal radical prostatectomy: the University of Leipzig experience of 2000 cases. J Endourol 2008;22:2319–26.
  16. Haller Av. Dissertatio inauguralis medica de telae cellulosa in fabrica corporis humani dignitate [Dissertatio]. Leiden: Leiden University; 1748.
  17. Steinke H. Irritating experiments. Haller’s concept and the European controversy on irritability and sensibility, 1750–90. Clio Med 2005;76:7–343.
  18. Bonaros N, Yang S, Ott HC, Kocher A. Cell therapy for ischemic heart disease. Panminerva Med 2004;46:13–23.
  19. Ott HC, Matthiesen TS, Goh SK, Black LD, Kren SM, Netoff TI, Taylor DA. Perfusion-decellularized matrix: using nature’s platform to engineer a bioartificial heart. Nat Med 2008;14:213–21.
  20. Tapias L, Ott HC. Organ transplantation: lung repair via cross-circulation. Nature Biomedical Engineering 2017;1:0052.
  21. Kitano K, Schwartz DM, Zhou H, Gilpin SE, Wojtkiewicz GR, Ren X, Sommer CA, Capilla AV, Mathisen DJ, Goldstein AM, Mostoslavsky G, Ott HC. Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts. Nat Commun 2017;8:765.
  22. Song JJ, Guyette JP, Gilpin SE, Gonzalez G, Vacanti JP, Ott HC. Regeneration and experimental orthotopic transplantation of a bioengineered kidney. Nat Med 2013;19:646–51.
  23. Jank BJ, Xiong L, Moser PT, Guyette JP, Ren X, Cetrulo CL, Leonard DA, Fernandez L, Fagan SP, Ott HC. Engineered composite tissue as a bioartificial limb graft. Biomaterials 2015;61:246–56.
  24. Gerli MFM, Guyette JP, Evangelista-Leite D, Ghoshhajra BB, Ott HC. Perfusion decellularization of a human limb: a novel platform for composite tissue engineering and reconstructive surgery. PLoS One 2018;13:e0191497.
  25. Zhang X, Chen X, Hong H, Hu R, Liu J, Liu C. Decellularized extracellular matrix scaffolds: recent trends and emerging strategies in tissue engineering. Bioactive Materials 2022;10:15–31.
  26. Corcoran RB, Chabner BA. Application of cell-free DNA analysis to cancer treatment. N Engl J Med 2018;18:1754–65.
  27. Ullah I, Abu-Dawud R, Busch JF, Rabien A, Erguen B, Fischer I, Reinke P, Kurtz A. VEGF – supplemented extracellular matrix is sufficient to induce endothelial differentiation of human iPSC. Biomaterials 2019;216:119283.
  28. Young BM, Shankar K, Tho CK, Pellegrino AR, Heise RL. Laminin-driven Epac/Rap1 regulation of epithelial barriers on decellularized matrix. Acta Biomater 2019;100:223–34.
  29. Cisneros-Villanueva M, Hidalgo-Pérez L, Rios-Romero M, Cedro-Tanda A, Ruiz-Villavicencio CA, Page K, Hastings R, Fernandez-Garcia D, Allsopp R, Fonseca-Montaño MA, Jimenez-Morales S, Padilla-Palma V, Shaw JA, Hidalgo-Miranda A. Cell-free DNA analysis in current cancer clinical trials: a review. Br J Cancer 2022;126:391–400.