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Journals / Akademik Gastroenteroloji Dergisi / 2026 / Cilt: 22 Sayı: 1

The relationship of HbsAg level with HBV DNA and liver fibrosis

HbsAg seviyesinin HBV DNA ve karaciğer fibrozisi ile ilişkisi

Ahmet Ramiz Baykan(Erzurum Bölge Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, Erzurum)0000-0001-6798-0240
Elmas Kasap(Manisa Celal Bayar Üniversitesi Tıp Fakültesi, Gastroenteroloji Bilim Dalı, Manisa)0000-0002-4335-1156
Pages
13–19
Publication Date
2023-04-30
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Although hepatitis B surface antigen titers are useful in predicting fibrosis in hepatitis B e-antigen positive patients, its success in predicting fibrosis in hepatitis B surface antigen negative patients was not as good as in hepatitis B e-antigen positive patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Backgorund and Aims: The level of covalently closed circular DNA has clinical significance in predicting the activity of the disease in patients with chronic hepatitis B.
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Key Findings & Data:Materials and Method: Biopsy results of patients who underwent liver biopsy for chronic hepatitis B between 2017-2020 were evaluated retrospectively, cross-sectionally.
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Conclusion & Impact:Conclusion: Although hepatitis B surface antigen titers are useful in predicting fibrosis in hepatitis B e-antigen positive patients, its success in predicting fibrosis in hepatitis B surface antigen negative patients was not as good as in hepatitis B e-antigen positive patients.
🔬Design:Araştırma Makalesi
📍Scope:2017-2020 Verileri
⚙️Variables:Hepatit B · fibrozis · HbsAg seviyesi

Abstract

Backgorund and Aims: The level of covalently closed circular DNA has clinical significance in predicting the activity of the disease in patients with chronic hepatitis B. Hepatitis B surface antigen level, which is an indirect indicator of covalently closed circular DNA level, may play an important role together with hepatitis B virus-DNA level in the management of chronic hepatitis B patients. In this study, it was aimed to compare the fibrosis scores, hepatitis B virus-DNA and hepatitis B surface antigen titers of the patients who underwent liver biopsy due to hepatitis B, taking into account the hepatitis B e-antigen status. Materials and Method: Biopsy results of patients who underwent liver biopsy for chronic hepatitis B between 2017-2020 were evaluated retrospectively, cross-sectionally. Fibrosis values in biopsy results were evaluated considering Hepatitis B e-antigen status. Results: The study group consisted of 128 patients, 71 (55.4%) male and 57 (44.5%) female. The mean age was 41.58 ± 14.27 in men and 43.63 ± 12.13 in women (p: 0.38). In hepatitis B e-antigen positive patients, hepatitis B surface antigen was found to be correlated with hepatitis B virus-DNA (p: < 0.01, r: 0.46), necroinflammatory activity (p: 0.03, r: -0.38) and fibrosis (p: < 0.01, r: -0.73). In hepatitis B e-antigen negative patients, hepatitis B surface antigen was not found to be associated with fibrosis. However, patients with advanced fibrosis had significantly higher hepatitis B virus-DNA (p: < 0.01) and hepatitis B surface antigen titers were significantly lower (p: < 0.01) compared to patients with mild fibrosis. Conclusion: Although hepatitis B surface antigen titers are useful in predicting fibrosis in hepatitis B e-antigen positive patients, its success in predicting fibrosis in hepatitis B surface antigen negative patients was not as good as in hepatitis B e-antigen positive patients.

Özet

Giriş ve Amaç: Kovalent olarak kapalı dairesel DNA düzeyinin kronik hepatit B hastalarında hastalığın aktivitesini öngörmede klinik önemi bulunmaktadır. Kovalent olarak kapalı dairesel DNA düzeyinin dolaylı bir göstergesi olan hepatit B yüzey antijeni düzeyi, kronik hepatit B hastalarının yönetiminde hepatit B virüs-DNA düzeyi ile birlikte önemli rol alabilir. Çalışmamızda, hepatit B nedeni ile karaciğer biyopsisi yapılan hastaların fibrozis skorları, hepatit B virüs-DNA ve hepatit B yüzey antijeni seviyelerinin hepatit B zarf antijeni durumu dikkate alınarak kıyaslanması amaçlandı. Gereç ve Yöntem: 2017-2020 yılları arasında kronik hepatit B nedeni ile karaciğer biyopsisi yapılan hastaların biyopsi sonuçları, retrospektif kesitsel olarak değerlendirildi. Biyopsi sonucunda fibrozis değerleri hepatit B zarf antijeni durumu göz önüne alınarak değerlendirildi. Bulgular: Çalışma grubunu 71 (%55.4) erkek, 57 (%44.5) kadın toplam 128 hasta oluşturdu. Ortalama yaş erkeklerde 41.58 ± 14.27, kadınlarda 43.63 ± 12.13 idi (p: 0.38). Hepatit B zarf antijeni pozitif hastalarda hepatit B yüzey antijeninin hepatit B virüs-DNA (p: <0.01, r: 0.46), nekroinflamatuvar aktivite (p: 0.03, r: -0.38) ve fibrozis (p: <0.01, r: -0.73) ile korele olduğu görüldü. Hepatit B zarf antijeni negatif hastalarda hepatit B yüzey antijen seviyesi fibrozis ile ilişkili olarak saptanmadı. Ancak ileri fibrozisi olan hastalarda hafif fibrozisi olanlara göre hepatit B virüs-DNA anlamlı olarak yüksek (p: <0.01) beraberinde hepatit B yüzey antijeni seviyeleri ise anlamlı olarak daha düşük saptandı (p: <0.01). Sonuç: Hepatit B yüzey antijeni seviyeleri hepatit B zarf antijeni pozitif hastalarda fibrozisi ön görmede faydalı olmakla birlikte hepatit B yüzey antijeni negatif hastalarda fibrozisi öngörmede başarısı hepatit B zarf antijeni pozitif hastalar kadar iyi saptanmamıştır.

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Cite This Article

Baykan, A. R., Kasap, E. (2023). The relationship of HbsAg level with HBV DNA and liver fibrosis. Akademik Gastroenteroloji Dergisi, Cilt: 22 Sayı: 1, 13–19. https://doi.org/10.17941/agd.1273939

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