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Journals / Anatolian Bryology / 2026 / Cilt: 11 Sayı: 1

Detection of some phenolic content of Grimmia ovalis (Hedw.) Lindb. and investigation of its antimicrobial activity with molecular docking technique

Grimmia ovalis (Hedw.) Lindb. Türünün Bazı Fenolik Bileşiklerinin Belirlenmesi ve Moleküler Yerleştirme Tekniği ile Antimikrobiyal Aktivitesinin Araştırılması

Zafer Çambay(FIRAT ÜNİVERSİTESİ, SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU)0000-0002-1170-7525
Harun Uslu(FIRAT ÜNİVERSİTESİ)0000-0001-8827-8557
Bünyamin Göktaş(FIRAT ÜNİVERSİTESİ)0000-0003-2345-7313
Kevser Özdemir Bayçinar(FIRAT ÜNİVERSİTESİ)0000-0002-5679-1417
Ümmügülsüm Tükenmez Emre(MARDİN ARTUKLU ÜNİVERSİTESİ)0000-0002-3224-1920
Mevlüt Alataş(MUNZUR ÜNİVERSİTESİ)0000-0003-0862-0258
Pages
52–58
Publication Date
2025-06-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We concluded that they interacted with residues crucial for antimicrobial activity on the mentioned macromolecule.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This study aims to investigate the phenolic compounds and pharmacological potential of Grimmia ovalis (Hedw.) Lindb. to understand their bioactive potential and to pioneer future research.
📊
Key Findings & Data:We calculated that compounds of 2,5-dihydroxybenzoic acid and caffeic acid would inhibit Staphylococcus aureus UDP-N-acetylenolpyruvylglucosamine reductase (MurB) at micromolar levels.
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Conclusion & Impact:We concluded that they interacted with residues crucial for antimicrobial activity on the mentioned macromolecule.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Briyofit · Antimikrobiyal Aktivite · Fenolik Bileşikler

Abstract

This study aims to investigate the phenolic compounds and pharmacological potential of Grimmia ovalis (Hedw.) Lindb. to understand their bioactive potential and to pioneer future research. It also aims to be one of the first studies on G. ovalis's in silico bioactivity. HPLC analysis revealed the detection of some phenolic compounds in G. ovalis extract. The study revealed the in silico antimicrobial potential of some phenolic compounds. We calculated that compounds of 2,5-dihydroxybenzoic acid and caffeic acid would inhibit Staphylococcus aureus UDP-N-acetylenolpyruvylglucosamine reductase (MurB) at micromolar levels. We concluded that they interacted with residues crucial for antimicrobial activity on the mentioned macromolecule.

Özet

Bu çalışma, Grimmia ovalis (Hedw.) Lindb.'in fenolik bileşenlerini ve farmakolojik potansiyelini araştırmayı, biyoaktif potansiyellerini anlamayı ve gelecekteki araştırmalara öncü olmayı amaçlamaktadır. Bununla beraber in silico biyoaktivite açısından G. ovalis üzerine yapılan ilk çalışmalardan biri olmayı hedeflemektedir. HPLC analizi, G. ovalis özütünün bazı fenolik bileşiklerinin tespitini ortaya koymuştur. Bazı fenolik bileşiklerin in silico antimikrobiyal potansiyeli ortaya çıkarılmıştır. 2,5-Dihidroksibenzoik asit ve Kafeik asit bileşiklerinin, Staphylococcus aureus UDP-N-asetilenolpiruvil glukozamin redüktaz (MurB) üzerinde mikromolar düzeyde inhibisyon yapacağı hesaplanmıştır. Bahsi geçen makromolekül üzerinde antimikrobiyal aktivite için önemli olan kalıntılar ile etkileşime girdiği sonucuna varılmıştır.

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Cite This Article

Çambay, Z., Uslu, H., Göktaş, B., Bayçinar, K. Ö., Emre, Ü. T., Alataş, M. (2025). Detection of some phenolic content of Grimmia ovalis (Hedw.) Lindb. and investigation of its antimicrobial activity with molecular docking technique. Anatolian Bryology, Cilt: 11 Sayı: 1, 52–58. https://doi.org/10.26672/anatolianbryology.1705249

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