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Journals / Ankara Sağlık Hizmetleri Dergisi / 2016 / Cilt: 15 - Sayı: 2

WNT Sinyal Yolağı ve Kanser

Wnt sinyal yolağı ve kanser

Buket ALTINOK
Asuman SUNGUROĞLU
Pages
27–38
Publication Date
2016-06-24
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We review the Wnt signaling pathway, the relationship between this pathway and CSC term and recent therapeutic approaches to target this pathway and their clinical applications

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Wnt signaling pathway is critically important in stem cell biology, both in homeostatic maintenance and regeneration of tissues and organs.
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Key Findings & Data:Aberrant activation of this pathway has been described as a key player in the development of a wide array of tumor types, via affecting the behavior of Cancer Stem Cells (CSCs).
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Conclusion & Impact:We review the Wnt signaling pathway, the relationship between this pathway and CSC term and recent therapeutic approaches to target this pathway and their clinical applications
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Wnt sinyal yolağı · kanser kök hücre · terapötik ilaçlar

Abstract

Wnt signaling pathway is critically important in stem cell biology, both in homeostatic maintenance and regeneration of tissues and organs. Aberrant activation of this pathway has been described as a key player in the development of a wide array of tumor types, via affecting the behavior of Cancer Stem Cells (CSCs). CSCs are believed to be responsible for disease relapse, as they possess drug-resistance properties.The development of new therapeutic drugs targeting this pathway topromise new hope to eliminate CSCs and achieve cancer eradication. We review the Wnt signaling pathway, the relationship between this pathway and CSC term and recent therapeutic approaches to target this pathway and their clinical applications

Özet

Wnt sinyal yolağı kök hücre biyolojisinde, doku ve organ rejenerasyonunda ve homeostatik devamlılığın sağlanmasında kritik bir öneme sahiptir. Bu yolağın anormal aktivasyonunun pek çok tümör tipinin gelişiminde anahtar bir rol oynadığı ve bu durumun kanser kök hücrelerin (KKH, cancer stem cell=CSC) davranışını etkilediği bilinmektedir. KKH’ler ilaca direnç gösterebilme özelliğinden dolayı hastalıkların nüks etmesinin temel nedeni olduğu düşünülmektedir. Wnt sinyal yolağını hedef alan yeni terapötik ilaçların keşfedilmesi, KKH’lerin elimine edilmesine ve kanserin yok edilmesine yönelik yeni umutlar vaat etmektedir. Bu derleme de Wnt sinyal yolağı, bu yolağın kanser kök hücre kavramı ile ilişkisi ve klinik uygulamalarını hedef alan yakın zamandaki terapötik yaklaşımlar tartışılmıştır

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Cite This Article

ALTINOK, B., SUNGUROĞLU, A. (2016). WNT Sinyal Yolağı ve Kanser. Ankara Sağlık Hizmetleri Dergisi, Cilt: 15 - Sayı: 2, 27–38. https://ajindex.com/articles/115583

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References (14)

  1. Ahmed, M.A., et al., 2010. CD24 is upregulated in inflammatory bowel disease andstimulates cell motility and colony formation. Inflamm. Bowel. Dis. 16,795–803.
  2. Al-Hajj, M., Wicha, M.S., ito-Hernandez, A., Morrison, S.J., Clarke, M.F., 2003.Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad.Sci. U. S. A 100, 3983–3988.
  3. Baron, J.A., et al., 2003. A randomized trial of aspirin to prevent colorectaladenomas. N. Engl. J. Med. 348, 891–899.
  4. Boon, E.M., et al., 2004. Sulindac targets nuclear beta-catenin accumulation andWnt signalling in adenomas of patients with familial adenomatous polyposisand in human colorectal cancer cell lines. Br. J. Cancer 90, 224–229.
  5. Bonnet, D., Dick, J.E. 1997. Human acute miyeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3(7);730-7.
  6. Boulais, P.E., Frenette, P.S., 2015. Making sense of hematopoietic stem cell niches.Blood 125, 2621–2629.
  7. Bowers, M., et al., 2015. Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development. Blood 125, 2678–2688.
  8. Brabletz, T., et al., 2005. Invasion and metastasis in colorectal cancer:epithelial-mesenchymal transition, mesenchymal–epithelial transition, stemcells and beta-catenin. Cells Tissues Organs 179, 56–65.
  9. Brudvik, K.W., Paulsen, J.E., Aandahl, E.M., Roald, B., Tasken, K., 2011. Protein kinaseA antagonist inhibits beta-catenin nuclear translocation: c-Myc and COX-2expression and tumor promotion in Apc(Min/+) mice. Mol. Cancer 10, 149. Cadigan, K.M., Liu, Y.I. 2006. Wnt signaling: complexity at the surface. J Cell Sci. 119(Pt 3):395-402.
  10. Castellone, M.D., Teramoto, H., Williams, B.O., Druey, K.M., Gutkind, J.S., 2005.Prostaglandin E2 promotes colon cancer cell growth through aGs-axin-beta-catenin signaling axis. Science 310, 1504–1510.
  11. Chen X., Yang J., Evans P.M., Liu C. 2008. Wnt signaling: the good and the bad. Acta Biochim Biophys Sin, 40(7); 577-94.
  12. Dandekar, S., et al., 2014. Wnt inhibition leads to improved chemosensitivity inpaediatric acute lymphoblastic leukaemia. Br. J. Haematol. 167, 87–99.
  13. De, M.C., et al., 2015. Dual cyclooxygenase and carbonic anhydrase inhibition bynonsteroidal anti-inflammatory drugs for the treatment of cancer. Curr. Med.Chem. 22, 2812–2818.
  14. DuBois, R.N., Giardiello, F.M., Smalley, W.E., 1996. Nonsteroidal anti-inflammatorydrugs, eicosanoids, and colorectal cancer prevention. Gastroenterol. Clin. NorthAm. 25, 773–791. Du