Journals / Balıkesir Medical Journal / 2026 / Cilt: 9 Sayı: 2

Transient hyperphosphatasemia following gastroenteritis: avoid over-investigation in otherwise healthy children

Gizem Yıldız(DOKUZ EYLÜL ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-9513-6661
Erkam Yıldırım(DOKUZ EYLÜL ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-5574-8214
Meral Torun Bayram(DOKUZ EYLÜL ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-3760-7028
Salih Kavukçu(DOKUZ EYLÜL ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-9959-881X
Alper Soylu(DOKUZ EYLÜL ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-5901-7398
Pages
109–113
Publication Date
2025-08-30
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Here, we report two children who were diagnosed with benign transient hyperphosphatasemia following gastroenteritis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Serum alkaline phosphatase concentration rises in some disease states.
📊
Key Findings & Data:On the other hand, benign transient hyperphosphatasemia is most commonly recognized in infants and children younger than 2 years of age.
💡
Conclusion & Impact:Here, we report two children who were diagnosed with benign transient hyperphosphatasemia following gastroenteritis.
🔬Design:Olgu Sunumu
📍Scope:Comprehensive Sample
⚙️Variables:geçici hiperfosfatazemi · çocuk · gastroenterit

Abstract

Serum alkaline phosphatase concentration rises in some disease states. On the other hand, benign transient hyperphosphatasemia is most commonly recognized in infants and children younger than 2 years of age. It has also been described in adults. Benign transient hyperphosphatasemia is a self-limiting condition that is usually accompanied by some infectious and allergic disorders. Therefore it is important to keep this entity in mind to avoid unnecessary investigations. Here, we report two children who were diagnosed with benign transient hyperphosphatasemia following gastroenteritis.

Özet

Serum alkalen fosfataz düzeyi bazı hastalık durumlarında yükselir. Öte yandan, beniyn geçici hiperfosfatazemi en sık sütçocuklarında ve 2 yaş altındaki çocuklarda görülür. Erişkinlerde de tanımlanmıştır. Beniyn geçici hiperfosfatazemi kendiliğinden düzelir ve genellikle enfeksiyöz ve allerjik hastalıklara eşlik eder. Bu nedenle, gereksiz incelemelerden kaçınmak için bu durumun akılda tutulması gerekir. Bu makalede gastroenterit sonrası beniyn geçici hiperfosfatazemi gelişen iki çocuk hasta bildirilmektedir.

🔖

Cite This Article

Yıldız, G., Yıldırım, E., Bayram, M. T., Kavukçu, S., Soylu, A. (2025). Transient hyperphosphatasemia following gastroenteritis: avoid over-investigation in otherwise healthy children. Balıkesir Medical Journal, Cilt: 9 Sayı: 2, 109–113. https://doi.org/10.33716/bmedj.1617632

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (7)

  1. Corathers S.D. (2006) The alkaline phosphatase level: nuances of a familiar test. Pediatr Rev., 27:382–384.
  2. Crofton P.M. (1988) What is the cause of benign transient hyperphosphatasemia? A study of 35 cases. Clin Chem., 34:335-340.
  3. Gualco G., Lava S.A., Garzoni L, et al. (2013) Transient benign hyperphophatasemia. J Pediatr Gastroenterol Nutr., 57:167-171.
  4. Huh S.Y., Feldman H.A., Cox JE, Gordon CM. (2009) Prevalence of transient hyperphosphatasemia among healthy infants and toddlers. Pediatrics. 124:703–709.
  5. Kraut JR, Metrick M., Maxwell NR, Kaplan MM., (1985) Isoenzyme studies in transient hyperphosphatasemia of infancy. Ten new cases and a review of the literature. Am J Dis Child., 139:736–740.
  6. Otero JL, González-Peralta RP, Andres JM, Jolley CD, Novak DA, Haafiz A. (2011) Elevated Alkaline Phosphatase in Children: An Algorithm to Determine When a "Wait and See" Approach is Optimal. Clin Med Insights Pediatr., 5:15-18.
  7. Schonhaut B L, Rocha R A. (2017) Hiperfosfatasemia transitoria benigna de la infancia: Serie clínica [Benign transient hyperphosphatasaemia in infants: Clinical series]. Rev Chil Pediatr., 88:169-175. Spanish. Shkalim Zemer V, Hoshen M, Levinsky Y, et al. (2023) Benign transient hyperphosphatasemia in infants and children: a retrospective database study. Eur J Pediatr. 2:1–6.