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Journals / Turkish Journal of Medical Sciences / 2015 / Cilt: 45 - Sayı: 2

The impact of one fraction of 8 Gy radiotherapy in palliative treatment of multiple myeloma patients with painful bone destructions

Milda RUDZIANSKIENE
ARTURAS INCIURA
ELONA JUOZAITYTE
Rolandas GERBUTAVICIUS
Renata SIMOLIUNIENE
Viktoras RUDZIANSKAS
Greta Emilia KIAVIALAITIS
Pages
364–371
Publication Date
2015-08-13
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: One fraction of 8 Gy regimen is effective in palliative treatment of MM patients with painful bone destructions.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/aim: Radiotherapy is required to overcome pain and to promote recalcification in multiple myeloma (MM) patients.
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Key Findings & Data:The aim of our prospective study was to evaluate the impact of one fraction of 8 Gy regimen in palliative treatment of MM.
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Conclusion & Impact:Conclusion: One fraction of 8 Gy regimen is effective in palliative treatment of MM patients with painful bone destructions.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Multiple myeloma · pain relief · radiotherapy

Abstract

Background/aim: Radiotherapy is required to overcome pain and to promote recalcification in multiple myeloma (MM) patients. The aim of our prospective study was to evaluate the impact of one fraction of 8 Gy regimen in palliative treatment of MM. Materials and methods: Forty-six patients with MM and painful bone destructions were treated by 8 Gy single fraction regimen. The visual analog scale was used for evaluation of pain. Analgesic use was measured prior to and after radiotherapy (4, 12, and 24 weeks). Recalcification was evaluated with radiographs before and after radiotherapy at 1 and 3 months. Quality of life questionnaires were completed before and 4 weeks after treatment. Results: Decrease of pain was observed in 78.3% cases: according to the international consensus on palliative radiotherapy criteria, 43.5% were found to be completely and 34.8% partially responsive. Reduction of analgesic use was present in 68.4% and complete cessation in 31.6%. Recalcification was present in 55%: a complete response was observed in 35% and a partial response in 20%. The side effects after treatment were of the first grade and reversible. Conclusion: One fraction of 8 Gy regimen is effective in palliative treatment of MM patients with painful bone destructions.

Özet

Background/aim: Radiotherapy is required to overcome pain and to promote recalcification in multiple myeloma (MM) patients. The aim of our prospective study was to evaluate the impact of one fraction of 8 Gy regimen in palliative treatment of MM. Materials and methods: Forty-six patients with MM and painful bone destructions were treated by 8 Gy single fraction regimen. The visual analog scale was used for evaluation of pain. Analgesic use was measured prior to and after radiotherapy (4, 12, and 24 weeks). Recalcification was evaluated with radiographs before and after radiotherapy at 1 and 3 months. Quality of life questionnaires were completed before and 4 weeks after treatment. Results: Decrease of pain was observed in 78.3% cases: according to the international consensus on palliative radiotherapy criteria, 43.5% were found to be completely and 34.8% partially responsive. Reduction of analgesic use was present in 68.4% and complete cessation in 31.6%. Recalcification was present in 55%: a complete response was observed in 35% and a partial response in 20%. The side effects after treatment were of the first grade and reversible. Conclusion: One fraction of 8 Gy regimen is effective in palliative treatment of MM patients with painful bone destructions.

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Cite This Article

RUDZIANSKIENE, M., INCIURA, A., JUOZAITYTE, E., GERBUTAVICIUS, R., SIMOLIUNIENE, R., RUDZIANSKAS, V., KIAVIALAITIS, G. E. (2015). The impact of one fraction of 8 Gy radiotherapy in palliative treatment of multiple myeloma patients with painful bone destructions. Turkish Journal of Medical Sciences, Cilt: 45 - Sayı: 2, 364–371. https://ajindex.com/articles/114024

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