The effects of prenatal long-duration exposure to 900-MHz electromagnetic field on the 21-day-old newborn male rat liver

Conclusion: The study results show that a 900-MHz EMF applied in the prenatal period caused oxidative stress and pathological alterations in the liver in the postnatal period.

📌 3 Key Takeaways

🎯

Objective & Hypothesis:Background/aim: To determine what effect a 900-MHz electromagnetic field (EMF) applied in the prenatal period would have on the liver in the postnatal period.

📊

Key Findings & Data:The experimental group was exposed to a 900-MHz EMF for 1 h daily during days 13?21 of pregnancy.

💡

Conclusion & Impact:Conclusion: The study results show that a 900-MHz EMF applied in the prenatal period caused oxidative stress and pathological alterations in the liver in the postnatal period.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Electromagnetic field · liver · male rat

Abstract

Background/aim: To determine what effect a 900-MHz electromagnetic field (EMF) applied in the prenatal period would have on the liver in the postnatal period. Materials and methods: At the start of the study, adult pregnant rats were divided into two groups, control and experimental. The experimental group was exposed to a 900-MHz EMF for 1 h daily during days 13?21 of pregnancy. After birth, no procedure was performed on either mothers or pups. Male rat pups (n = 6) from the control group mothers (CGMR) and male rat pups (n = 6) from the experimental group mothers (EGMR) were sacrificed on postnatal day 21. Results: Biochemical analyses showed that malondialdehyde and superoxide dismutase values increased and glutathione levels decreased in the EGMR pups. Marked hydropic degeneration in the parenchyma, particularly in pericentral regions, was observed in light microscopic examination of EGMR sections stained with hematoxylin and eosin. Examinations under transmission electron microscope revealed vacuolization in the mitochondria, expansion in the endoplasmic reticulum, and necrotic hepatocytes. Conclusion: The study results show that a 900-MHz EMF applied in the prenatal period caused oxidative stress and pathological alterations in the liver in the postnatal period.

Özet

Background/aim: To determine what effect a 900-MHz electromagnetic field (EMF) applied in the prenatal period would have on the liver in the postnatal period. Materials and methods: At the start of the study, adult pregnant rats were divided into two groups, control and experimental. The experimental group was exposed to a 900-MHz EMF for 1 h daily during days 13?21 of pregnancy. After birth, no procedure was performed on either mothers or pups. Male rat pups (n = 6) from the control group mothers (CGMR) and male rat pups (n = 6) from the experimental group mothers (EGMR) were sacrificed on postnatal day 21. Results: Biochemical analyses showed that malondialdehyde and superoxide dismutase values increased and glutathione levels decreased in the EGMR pups. Marked hydropic degeneration in the parenchyma, particularly in pericentral regions, was observed in light microscopic examination of EGMR sections stained with hematoxylin and eosin. Examinations under transmission electron microscope revealed vacuolization in the mitochondria, expansion in the endoplasmic reticulum, and necrotic hepatocytes. Conclusion: The study results show that a 900-MHz EMF applied in the prenatal period caused oxidative stress and pathological alterations in the liver in the postnatal period.

Keywords

Electromagnetic field liver male rat prenatal period

🔖

Cite This Article

TOPAL, Z., HANCI, H., MERCANTEPE, T., EROL, H. S., KELEŞ, O. N., KAYA, H., MUNGAN, S., ODACI, E. (2015). The effects of prenatal long-duration exposure to 900-MHz electromagnetic field on the 21-day-old newborn male rat liver. Turkish Journal of Medical Sciences, Cilt: 45 - Sayı: 2, 291–297. https://ajindex.com/articles/114009

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (12)

Ozguner F, Oktem F, Ayata A, Koyu A, Yilmaz HR. A novel antioxidant agent caffeic acid phenethyl ester prevents long- term mobile phone exposure-induced renal impairment in rat. Mol Cell Biochem 2005; 277: 73–80.
Maaroufi K, Had-Aissouni L, Melon C, Sakly M, Abdelmelek H, Poucet B, Save E. Spatial learning, monoamines and oxidative stress in rats exposed to 900 MHz electromagnetic field in combination with iron overload. Behav Brain Res 2014; 258: 80–89.
Aydin B, Akar A. Effects of a 900-MHz electromagnetic field on oxidative stress parameters in rat lymphoid organs, polymorphonuclear leukocytes and plasma. Arch Med Res 2011; 42: 261–267.
Esmekaya MA, Aytekin E, Ozgur E, Güler G, Ergun MA, Omeroğlu S, Seyhan N. Mutagenic and morphologic impacts of 1.8 GHz radiofrequency radiation on human peripheral blood lymphocytes (hPBLs) and possible protective role of pre-treatment with Ginkgo biloba (EGb 761). Sci Total Environ 2011; 410–411: 59–64.
Kiray A, Tayefi H, Kiray M, Bagriyanik HA, Pekcetin C, Ergur BU, Ozogul C. The effects of exposure to electromagnetic field on rat myocardium. Toxicol Ind Health 2013; 29: 418–425.
Hekmat A, Saboury AA, Moosavi-Movahedi AA. The toxic effects of mobile phone radiofrequency (940 MHz) on the structure of calf thymus DNA. Ecotoxicol Environ Saf 2013; 88: 35–41.
Deng Y, Zhang Y, Jia S, Liu J, Liu Y, Xu W, Liu L. Effects of aluminum and extremely low frequency electromagnetic radiation on oxidative stress and memory in brain of mice. Biol Trace Elem Res 2013; 156: 243–252.
Ozturk A, Baltaci AK, Mogulkoc R, Oztekin E. Zinc prevention of electromagnetically induced damage to rat testicle and kidney tissues. Biol Trace Elem Res 2003; 96: 247–254.
Salem A, Hafedh A, Rached A, Mohsen S, Khémais BR. Zinc prevents hematological and biochemical alterations induced by static magnetic field in rats. Pharmacol Rep 2005; 57: 616–622.
Hancı H, Odacı E, Kaya H, Aliyazıcıoğlu Y, Turan İ, Demir S, Çolakoğlu S. The effect of prenatal exposure to 900-MHz electromagnetic field on the 21-old-day rat testicle. Reprod Toxicol 2013; 42: 203–209.
İkinci A, Odacı E, Yıldırım M, Kaya H, Akça M, Hancı H, Aslan A, Sönmez OF, Baş O. The effects of prenatal exposure to a 900 megahertz electromagnetic field on hippocampus morphology and learning behavior in rat pups. NeuroQuantology 2013; 11: 582–590.
Baş O, Sönmez OF, Aslan A, İkinci A, Hancı H, Yıldırım M, Kaya H, Akça M, Odacı E. Pyramidal cell loss in the cornu ammonis of 32-day-old female rats following