Effects of phenytoin injection on vocal cord healing after mechanical trauma: An experimental study

Abstract

Background/aim: Phenytoin is an anticonvulsant drug which causes fibroblast proliferation, collagen synthesis, and an increase in epidermal growth factor. Therefore, the aim of the present study is to evaluate the effect of phenytoin injection on the wound healing process in rats with vocal cord injury by histopathological methods. Materials and methods: The vocal cords of 10 albino Wistar rats were damaged bilaterally; the left vocal cord was kept as the control group. Phenytoin was injected in the right vocal cord. Ten rats were sacrificed. The thickness of the lamina propria and density of the fibroblast and collagen were evaluated histopathologically.Results: Thickness of the lamina propria was 18.0 ± 7.1 ?m in the control group, 65.5 ± 10.7 ?m in the phenytoin group. The density of fibroblast and collagen were statistically lower in the control group compared the phenytoin group (P