AI Summary & Key Takeaways
AI InsightResults: The results showed production of homogenous nanofibers-based scaffold diameter between 80 nm and 470 nm that contains the polymers used in the spinning process and the entrapped Baicalein molecules within the nanofiber structure.
📌 3 Key Takeaways
Abstract
Background/aim: Bone tumor is one of the major causes of tissue bone loss, particularly after performing surgical excision operation to bone lesion that needs to be replaced by biomaterials and ensure a complete filling of tissue-loss spaces. The purpose of our study was to produce a nanofiber-based bone graft scaffold to fill the gaps resulted from bone cancer treatment and also capable of carrying functional molecules that can play a major role in preventing further cancer growth at the targeted bone tissue. Materials and methods: Electrospinning method was used in order to produce nanofibers from different kinds of polymers; Hyaluronic acid HA , Polyethylene oxide PEO and Polyvinyl alcohol PVA blended with different concentrations of herbal antibiotic and anti cancer flavonoid molecules called Baicalein BE . The morphological and chemical structures of scaffold samples were studied using Scanning Electron Microscope SEM , Fourier Transform Infrared-spectroscopy FT-IR and Surface-enhanced Raman spectroscopy SERS Analysis. Results: The results showed production of homogenous nanofibers-based scaffold diameter between 80 nm and 470 nm that contains the polymers used in the spinning process and the entrapped Baicalein molecules within the nanofiber structure. Conclusion: It was concluded that successful formation of bone tissue mimicking scaffold can be achieved by using Electrospinning method that produces nonwoven nanofibers and at the same time can hold functional anticancer agent such as Baicalein, which may allow using these types of scaffold in bone cancer treatment procedures.