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Journals / Turkish Journal of Medical Sciences / 2020 / Cilt: 50 - Sayı: 4

Neurotrophic factors in bipolar disorders patients with manic episode

Özgür Korhan TUNÇEL
Gökhan SARISOY
Eda ÇETİN
Ebru KAYNAR TUNÇEL
Birşen BİLGİCİ
Arzu KARAUSTAOĞLU
Pages
985–993
Publication Date
2020-08-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: When controlled for age, BMI and cortisol, it was found that the serum levels of BDNF, NGF, NT-3, VEGF and FGF-2 of bipolar manic episode patients were not statistically different compared to those of the control group.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aim: Neurotrophins are one of the most important molecule groups affecting cerebral neuroplasticity.
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Key Findings & Data:Materials and methods: We measured serum levels of brain-derived neurotrophic factor BDNF , nerve growth factor NGF , neurotrophin-3 NT-3 , glial cell-line derived neurotrophic factor GDNF , vascular endothelial growth factor VEGF , insulin-like growth factor-1 IGF-1 , fibroblast growth factor FGF -2, neuritin 1 Nrn 1 in bipolar 1 manic episode patients n = 45 and healthy control group.
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Conclusion & Impact:Results: When controlled for age, BMI and cortisol, it was found that the serum levels of BDNF, NGF, NT-3, VEGF and FGF-2 of bipolar manic episode patients were not statistically different compared to those of the control group.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Bipolar disorder · neurotrophic factors · IGF-1

Abstract

Background/aim: Neurotrophins are one of the most important molecule groups affecting cerebral neuroplasticity. The amount of evidence about the role of changes in neuroplasticity in the pathophysiology of bipolar disease is growing. Materials and methods: We measured serum levels of brain-derived neurotrophic factor BDNF , nerve growth factor NGF , neurotrophin-3 NT-3 , glial cell-line derived neurotrophic factor GDNF , vascular endothelial growth factor VEGF , insulin-like growth factor-1 IGF-1 , fibroblast growth factor FGF -2, neuritin 1 Nrn 1 in bipolar 1 manic episode patients n = 45 and healthy control group. Results: When controlled for age, BMI and cortisol, it was found that the serum levels of BDNF, NGF, NT-3, VEGF and FGF-2 of bipolar manic episode patients were not statistically different compared to those of the control group. GDNF level and Nrn 1 levels were significantly lower P = 0.003 and P = 0.025 respectively while IGF-1 levels were significantly higher than the control group P = 0.0001 . ROC analysis was performed and the area under the the curve was calculated as 0.737, 0.766 for GDNF, IGF-1 respectively. Conclusion: The changes in the levels of GDNF, IGF-1 and Nrn 1 might be involved in pathopysiology of bipolar disorder, and GDNF, IGF-1 may be considered as state markers in bipolar manic episode.

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Cite This Article

TUNÇEL, Ö. K., SARISOY, G., ÇETİN, E., TUNÇEL, E. K., BİLGİCİ, B., KARAUSTAOĞLU, A. (2020). Neurotrophic factors in bipolar disorders patients with manic episode. Turkish Journal of Medical Sciences, Cilt: 50 - Sayı: 4, 985–993. https://ajindex.com/articles/113185

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