AI Summary & Key Takeaways
AI InsightOverall, 226 75% patients were fed by orally and 74 25% patients fed by enteral tube feeding.
📌 3 Key Takeaways
Abstract
Background/aim: Critically ill patients are at risk of developing gastrointestinal GI bleeding due to stress causing mucosal damage. Aim of the study was to determine the effect of oral/enteral nutrition with or without concomitant pantoprazole on upper GI bleeding in low risk critically ill patients. Materials and methods: This was a prospective, randomized, open-label, multicenter study conducted with intensive care unit ICU patients receiving oral/enteral nutritional support. Patients were randomly assigned into two groups including intervention group received oral/EN plus pantoprazole and control group received only oral/EN . Results: A total of 300 patients intervention group: 152, control group: 148 participated in the study. Overall, 226 75% patients were fed by orally and 74 25% patients fed by enteral tube feeding. Median duration of nutritional support 4 range: 2-33 days. Overt upper GI bleeding was noted only in one patient 0.65% who was in the intervention group. The overall length of ICU stay of 4 2-105 days, while ICU stay was significantly longer in the intervention group than in the control group P = 0.006 . Conclusions: Our findings seems to indicate that in patients who are at low risk for GI bleeding and under oral/enteral nutritional support, the use of PPIs may not reduce the risk of bleeding, however these results are imprecise because of low event GI bleeding rate and limited power.