SavedAdd your journal

Journals / Experimed / 2022 / Volume: 12 Issue: 3

Alcohol Withdrawal at Different Points in Time Distinctly Affects Wistar Rats’ Spatial Reference Memory

Ilknur Dursun(İSTİNYE ÜNİVERSİTESİ)0000-0001-7094-3336
Birsen Elibol(İSTANBUL MEDENİYET ÜNİVERSİTESİ)0000-0002-9462-0862
Ebru Hacıosmanoğlu(BEZM-İ ÂLEM VAKIF ÜNİVERSİTESİ)0000-0001-9559-4515
Havva (ewa) Doğru(ORTA DOĞU TEKNİK ÜNİVERSİTESİ)0000-0002-0285-2253
Journal
Experimed
Pages
—
Publication Date
2022-12-31
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The study’s results suggest that alcohol withdrawal itself, even after a relatively short period of alcohol intake, may also adversely affect memory.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: The consumption of alcohol by adults may lead to severe neurodegeneration and significant behavioral problems.
📊
Key Findings & Data:An increase in the harmful effects of alcohol becomes aggravated after the development of alcohol dependence.
💡
Conclusion & Impact:Conclusion: The study’s results suggest that alcohol withdrawal itself, even after a relatively short period of alcohol intake, may also adversely affect memory.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Alcohol withdrawal · spatial reference memory · Wistar rat

Abstract

Objectives: The consumption of alcohol by adults may lead to severe neurodegeneration and significant behavioral problems. An increase in the harmful effects of alcohol becomes aggravated after the development of alcohol dependence. Furthermore, the serious damage from chronic alcohol intake on the hippocampus has gained attention due to its role on learning and memory. Therefore, the study aimed to examine the retention of spatial reference memory during different points in time regarding alcohol withdrawal in Wistar rats. Materials and Methods: The study has therefore administered alcohol to rats at gradually increasing doses from 4.5 to 12 g/kg/day in a binge-like manner using the intragastric intubation technique for six days followed by 24, 48, or 96 hours of alcohol withdrawal. To evaluate the effects of alcohol withdrawal, the alcohol-exposed rats have been tested regarding their spatial reference memory. Results: An adverse effect from alcohol withdrawal on memory retention was observed in the 24-hour alcohol withdrawal group. This effect decreased at 48 hours of withdrawal, but reappeared at 96 hours. Conclusion: The study’s results suggest that alcohol withdrawal itself, even after a relatively short period of alcohol intake, may also adversely affect memory. Therefore, withdrawal therapy from alcohol should be performed in a controlled manner to protect the brain from extended alcohol withdrawal-induced spatial memory impairments.

🔖

Cite This Article

Dursun, I., Elibol, B., Hacıosmanoğlu, E., Doğru, H. (. (2022). Alcohol Withdrawal at Different Points in Time Distinctly Affects Wistar Rats’ Spatial Reference Memory. Experimed, Volume: 12 Issue: 3. https://doi.org/10.26650/experimed.1193314

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (26)

  1. Yosifov DY, Wolf C, Stilgenbauer S, Mertens D. From Biology to Therapy: The CLL Success Story. Hemasphere 2019; 3(2): e175. [CrossRef] google scholar
  2. Rai KR, Jain P. Chronic lymphocytic leukemia (CLL)-Then and now. Am J Hematol 2016; 91(3): 330-40. [CrossRef] google scholar
  3. Kay NE, Hampel PJ, Van Dyke DL, Parikh SA. CLL update 2022: A continuing evolution in care. Blood Rev 2022; 54: 100930. [CrossRef] google scholar
  4. Hallek M. Chronic lymphocytic leukemia: 2020 update on diagnosis, risk stratification and treatment. Am J Hematol 2019; 94(11): 1266-87. [CrossRef] google scholar
  5. Malavasi F, Deaglio S, Damle R, Cutrona G, Ferrarini M, Chiorazzi N. CD38 and chronic lymphocytic leukemia: a decade later. Blood 2011; 118(13): 3470-8. [CrossRef] google scholar
  6. Kucuksezer UC, Aktas Cetin E, Esen F, Tahrali I, Akdeniz N, Gelmez MY, et al. The Role of natural killer cells in autoimmune diseases. Front Immunol 2021; 12: 622306. [CrossRef] google scholar
  7. Gardiner CM. NK cell metabolism. J Leukoc Biol 2019; 105(6): 1235-42. [CrossRef] google scholar
  8. Bi J, Tian Z. NK cell dysfunction and checkpoint immunotherapy. Front Immunol 2019; 10: 1999. [CrossRef] google scholar
  9. Sportoletti P, De Falco F, Del Papa B, Baldoni S, Guarente V, Marra A, et al. NK cells in chronic lymphocytic leukemia and their therapeutic implications. Int J Mol Sci 2021; 22(13). [CrossRef] google scholar
  10. Beatty GL, Gladney WL. Immune escape mechanisms as a guide for cancer immunotherapy. Clin Cancer Res 2015; 21(4): 687-92. [CrossRef] google scholar
  11. Yao Y, Lin X, Li F, Jin J, Wang H. The global burden and attributable risk factors of chronic lymphocytic leukemia in 204 countries and territories from 1990 to 2019: analysis based on the global burden of disease study 2019. Biomed Eng Online 2022; 21(1): 4. [CrossRef] google scholar
  12. Yoshino T, Tanaka T, Sato Y. Differential diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma and other indolent lymphomas, including mantle cell lymphoma. J Clin Exp Hematop 2020; 60(4): 124-9. [CrossRef] google scholar
  13. Chennamadhavuni A, Lyengar V, Shimanovsky A. Leukemia. In StatPearls. Treasure Island (FL); 2022. google scholar
  14. Vlachonikola E, Stamatopoulos K, Chatzidimitriou A. T cells in chronic lymphocytic leukemia: A two-edged sword. Front Immunol 2020; 11: 612244. [CrossRef] google scholar
  15. MacFarlane AWt, Jillab M, Smith MR, Alpaugh RK, Cole ME, Litwin S, et al. NK cell dysfunction in chronic lymphocytic leukemia is associated with loss of the mature cells expressing inhibitory killer cell Ig-like receptors. Oncoimmunology 2017; 6(7): e1330235. [CrossRef] google scholar
  16. Zhu F, McCaw L, Spaner DE, Gorczynski RM. Targeting the IL-17/ IL-6 axis can alter growth of chronic lymphocytic leukemia in vivo/ in vitro. Leuk Res 2018; 66: 28-38. [CrossRef] google scholar
  17. Zhao J, Chen X, Herjan T, Li X. The role of interleukin-17 in tumor development and progression. J Exp Med 2020; 217(1). [CrossRef] google scholar
  18. Chen J, Liao MY, Gao XL, Zhong Q, Tang TT, Yu X, et al. IL-17A induces pro-inflammatory cytokines production in macrophages via MAPKinases, NF-KappaB and AP-1. Cell Physiol Biochem 2013; 32(5): 1265-74. [CrossRef] google scholar
  19. Bankir M, Acik DY. IL-17 and IL-23 levels in patients with early-stage chronic lymphocytic leukemia. North Clin Istanb 2021; 8(1): 24-30. [CrossRef] google scholar
  20. Jain P, Javdan M, Feger FK, Chiu PY, Sison C, Damle RN, et al. Th17 and non-Th17 interleukin-17-expressing cells in chronic lymphocytic leukemia: delineation, distribution, and clinical relevance. Haematologica 2012; 97(4): 599-607. [CrossRef] google scholar
  21. Martinez-Espinosa I, Serrato JA, Ortiz-Quintero B. Role of IL-10-producing natural killer cells in the regulatory mechanisms of inflammation during systemic infection. Biomolecules 2021; 12(1). [CrossRef] google scholar
  22. Phoksawat W, Jumnainsong A, Leelayuwat N, Leelayuwat C. IL-17 production by NKG2D-expressing CD56+ T cells in type 2 diabetes. Mol Immunol 2019; 106: 22-8. [CrossRef] google scholar
  23. Fayad L, Keating MJ, Reuben JM, O'Brien S, Lee BN, Lerner S, et al. Interleukin-6 and interleukin-10 levels in chronic lymphocytic leukemia: correlation with phenotypic characteristics and outcome. Blood 2001; 97(1): 256-63. [CrossRef] google scholar
  24. De Cecco L, Capaia M, Zupo S, Cutrona G, Matis S, Brizzolara A, et al. Interleukin 21 Controls mRNA and MicroRNA expression in CD40-activated chronic lymphocytic leukemia cells. PLoS One 2015; 10(8): e0134706. [CrossRef] google scholar
  25. de Totero D, Meazza R, Capaia M, Fabbi M, Azzarone B, Balleari E, et al. The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways. Blood 2008; 111(2): 517-24. [CrossRef] google scholar
  26. Brady J, Hayakawa Y, Smyth MJ, Nutt SL. IL-21 induces the functional maturation of murine NK cells. J Immunol 2004; 172(4): 2048-58. [CrossRef] google scholar